Summary | |
---|---|
Symbol | SERPINA1 |
Name | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 |
Aliases | AAT; A1A; PI1; alpha-1-antitrypsin; A1AT; alpha1AT; protease inhibitor 1 (anti-elastase), alpha-1-antitrypsi ...... |
Chromosomal Location | 14q32.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted. Endoplasmic reticulum. Note=The S and Z allele are not secreted effectively and accumulate intracellularly in the endoplasmic reticulum.; SUBCELLULAR LOCATION: Short peptide from AAT: Secreted, extracellular space, extracellular matrix. |
Domain |
PF00079 Serpin (serine protease inhibitor) |
Function |
Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin.; FUNCTION: Short peptide from AAT: reversible chymotrypsin inhibitor. It also inhibits elastase, but not trypsin. Its major physiological function is the protection of the lower respiratory tract against proteolytic destruction by human leukocyte elastase (HLE). |
Biological Process |
GO:0002526 acute inflammatory response GO:0002576 platelet degranulation GO:0006887 exocytosis GO:0006888 ER to Golgi vesicle-mediated transport GO:0006900 membrane budding GO:0006901 vesicle coating GO:0006903 vesicle targeting GO:0006953 acute-phase response GO:0007596 blood coagulation GO:0007599 hemostasis GO:0010466 negative regulation of peptidase activity GO:0010951 negative regulation of endopeptidase activity GO:0016050 vesicle organization GO:0045055 regulated exocytosis GO:0045861 negative regulation of proteolysis GO:0048193 Golgi vesicle transport GO:0048199 vesicle targeting, to, from or within Golgi GO:0048207 vesicle targeting, rough ER to cis-Golgi GO:0048208 COPII vesicle coating GO:0050817 coagulation GO:0050878 regulation of body fluid levels GO:0051346 negative regulation of hydrolase activity GO:0051640 organelle localization GO:0051648 vesicle localization GO:0051650 establishment of vesicle localization GO:0051656 establishment of organelle localization GO:0052547 regulation of peptidase activity GO:0052548 regulation of endopeptidase activity GO:0090114 COPII-coated vesicle budding |
Molecular Function |
GO:0001948 glycoprotein binding GO:0002020 protease binding GO:0004857 enzyme inhibitor activity GO:0004866 endopeptidase inhibitor activity GO:0004867 serine-type endopeptidase inhibitor activity GO:0030414 peptidase inhibitor activity GO:0061134 peptidase regulator activity GO:0061135 endopeptidase regulator activity |
Cellular Component |
GO:0005578 proteinaceous extracellular matrix GO:0005788 endoplasmic reticulum lumen GO:0005793 endoplasmic reticulum-Golgi intermediate compartment GO:0030133 transport vesicle GO:0030134 ER to Golgi transport vesicle GO:0030135 coated vesicle GO:0030141 secretory granule GO:0031091 platelet alpha granule GO:0031093 platelet alpha granule lumen GO:0031983 vesicle lumen GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane GO:0034774 secretory granule lumen GO:0060205 cytoplasmic membrane-bounded vesicle lumen GO:0099503 secretory vesicle |
KEGG |
hsa04610 Complement and coagulation cascades |
Reactome |
R-HSA-446203: Asparagine N-linked glycosylation R-HSA-204005: COPII (Coat Protein 2) Mediated Vesicle Transport R-HSA-5694530: Cargo concentration in the ER R-HSA-199977: ER to Golgi Anterograde Transport R-HSA-109582: Hemostasis R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-199991: Membrane Trafficking R-HSA-392499: Metabolism of proteins R-HSA-6798695: Neutrophil degranulation R-HSA-76002: Platelet activation, signaling and aggregation R-HSA-114608: Platelet degranulation R-HSA-597592: Post-translational protein modification R-HSA-76005: Response to elevated platelet cytosolic Ca2+ R-HSA-948021: Transport to the Golgi and subsequent modification R-HSA-5653656: Vesicle-mediated transport |
Summary | |
---|---|
Symbol | SERPINA1 |
Name | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 |
Aliases | AAT; A1A; PI1; alpha-1-antitrypsin; A1AT; alpha1AT; protease inhibitor 1 (anti-elastase), alpha-1-antitrypsi ...... |
Chromosomal Location | 14q32.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between SERPINA1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between SERPINA1 and anti-tumor immunity in human cancer.
|
Summary | |
---|---|
Symbol | SERPINA1 |
Name | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 |
Aliases | AAT; A1A; PI1; alpha-1-antitrypsin; A1AT; alpha1AT; protease inhibitor 1 (anti-elastase), alpha-1-antitrypsi ...... |
Chromosomal Location | 14q32.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
[ TOP ]
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Statistical results of SERPINA1 in screening data sets for detecting immune reponses.
|
Summary | |
---|---|
Symbol | SERPINA1 |
Name | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 |
Aliases | AAT; A1A; PI1; alpha-1-antitrypsin; A1AT; alpha1AT; protease inhibitor 1 (anti-elastase), alpha-1-antitrypsi ...... |
Chromosomal Location | 14q32.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of SERPINA1 in various data sets.
|
Points in the above scatter plot represent the mutation difference of SERPINA1 in various data sets.
|
Summary | |
---|---|
Symbol | SERPINA1 |
Name | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 |
Aliases | AAT; A1A; PI1; alpha-1-antitrypsin; A1AT; alpha1AT; protease inhibitor 1 (anti-elastase), alpha-1-antitrypsi ...... |
Chromosomal Location | 14q32.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SERPINA1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | SERPINA1 |
Name | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 |
Aliases | AAT; A1A; PI1; alpha-1-antitrypsin; A1AT; alpha1AT; protease inhibitor 1 (anti-elastase), alpha-1-antitrypsi ...... |
Chromosomal Location | 14q32.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SERPINA1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SERPINA1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | SERPINA1 |
Name | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 |
Aliases | AAT; A1A; PI1; alpha-1-antitrypsin; A1AT; alpha1AT; protease inhibitor 1 (anti-elastase), alpha-1-antitrypsi ...... |
Chromosomal Location | 14q32.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SERPINA1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | SERPINA1 |
Name | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 |
Aliases | AAT; A1A; PI1; alpha-1-antitrypsin; A1AT; alpha1AT; protease inhibitor 1 (anti-elastase), alpha-1-antitrypsi ...... |
Chromosomal Location | 14q32.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of SERPINA1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | SERPINA1 |
Name | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 |
Aliases | AAT; A1A; PI1; alpha-1-antitrypsin; A1AT; alpha1AT; protease inhibitor 1 (anti-elastase), alpha-1-antitrypsi ...... |
Chromosomal Location | 14q32.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between SERPINA1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | SERPINA1 |
Name | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 |
Aliases | AAT; A1A; PI1; alpha-1-antitrypsin; A1AT; alpha1AT; protease inhibitor 1 (anti-elastase), alpha-1-antitrypsi ...... |
Chromosomal Location | 14q32.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting SERPINA1 collected from DrugBank database. |
Details on drugs targeting SERPINA1.
|