Summary | |
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Symbol | SERPINA3 |
Name | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 |
Aliases | alpha-1-antichymotrypsin; AACT; serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, ...... |
Chromosomal Location | 14q32.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted. |
Domain |
PF00079 Serpin (serine protease inhibitor) |
Function |
Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2. |
Biological Process |
GO:0001894 tissue homeostasis GO:0002526 acute inflammatory response GO:0002576 platelet degranulation GO:0006887 exocytosis GO:0006953 acute-phase response GO:0007586 digestion GO:0010466 negative regulation of peptidase activity GO:0010669 epithelial structure maintenance GO:0010951 negative regulation of endopeptidase activity GO:0019216 regulation of lipid metabolic process GO:0022600 digestive system process GO:0030277 maintenance of gastrointestinal epithelium GO:0045055 regulated exocytosis GO:0045861 negative regulation of proteolysis GO:0048871 multicellular organismal homeostasis GO:0051346 negative regulation of hydrolase activity GO:0052547 regulation of peptidase activity GO:0052548 regulation of endopeptidase activity GO:0060249 anatomical structure homeostasis |
Molecular Function |
GO:0004857 enzyme inhibitor activity GO:0004866 endopeptidase inhibitor activity GO:0004867 serine-type endopeptidase inhibitor activity GO:0030414 peptidase inhibitor activity GO:0061134 peptidase regulator activity GO:0061135 endopeptidase regulator activity |
Cellular Component |
GO:0030141 secretory granule GO:0031091 platelet alpha granule GO:0031093 platelet alpha granule lumen GO:0031983 vesicle lumen GO:0034774 secretory granule lumen GO:0060205 cytoplasmic membrane-bounded vesicle lumen GO:0072562 blood microparticle GO:0099503 secretory vesicle |
KEGG | - |
Reactome |
R-HSA-109582: Hemostasis R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-6798695: Neutrophil degranulation R-HSA-76002: Platelet activation, signaling and aggregation R-HSA-114608: Platelet degranulation R-HSA-76005: Response to elevated platelet cytosolic Ca2+ |
Summary | |
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Symbol | SERPINA3 |
Name | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 |
Aliases | alpha-1-antichymotrypsin; AACT; serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, ...... |
Chromosomal Location | 14q32.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between SERPINA3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between SERPINA3 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | SERPINA3 |
Name | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 |
Aliases | alpha-1-antichymotrypsin; AACT; serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, ...... |
Chromosomal Location | 14q32.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of SERPINA3 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | SERPINA3 |
Name | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 |
Aliases | alpha-1-antichymotrypsin; AACT; serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, ...... |
Chromosomal Location | 14q32.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of SERPINA3 in various data sets.
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Points in the above scatter plot represent the mutation difference of SERPINA3 in various data sets.
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Summary | |
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Symbol | SERPINA3 |
Name | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 |
Aliases | alpha-1-antichymotrypsin; AACT; serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, ...... |
Chromosomal Location | 14q32.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SERPINA3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | SERPINA3 |
Name | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 |
Aliases | alpha-1-antichymotrypsin; AACT; serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, ...... |
Chromosomal Location | 14q32.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SERPINA3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SERPINA3. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | SERPINA3 |
Name | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 |
Aliases | alpha-1-antichymotrypsin; AACT; serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, ...... |
Chromosomal Location | 14q32.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SERPINA3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | SERPINA3 |
Name | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 |
Aliases | alpha-1-antichymotrypsin; AACT; serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, ...... |
Chromosomal Location | 14q32.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of SERPINA3 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | SERPINA3 |
Name | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 |
Aliases | alpha-1-antichymotrypsin; AACT; serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, ...... |
Chromosomal Location | 14q32.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between SERPINA3 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | SERPINA3 |
Name | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 |
Aliases | alpha-1-antichymotrypsin; AACT; serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, ...... |
Chromosomal Location | 14q32.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting SERPINA3 collected from DrugBank database. |
Details on drugs targeting SERPINA3.
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