Summary | |
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Symbol | SERPINB9 |
Name | serpin peptidase inhibitor, clade B (ovalbumin), member 9 |
Aliases | CAP3; PI9; serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 9; CAP-3; PI-9; cytoplasmi ...... |
Chromosomal Location | 6p25.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm. |
Domain |
PF00079 Serpin (serine protease inhibitor) |
Function |
Granzyme B inhibitor. |
Biological Process |
GO:0001906 cell killing GO:0001909 leukocyte mediated cytotoxicity GO:0001910 regulation of leukocyte mediated cytotoxicity GO:0001911 negative regulation of leukocyte mediated cytotoxicity GO:0002228 natural killer cell mediated immunity GO:0002443 leukocyte mediated immunity GO:0002444 myeloid leukocyte mediated immunity GO:0002448 mast cell mediated immunity GO:0002449 lymphocyte mediated immunity GO:0002683 negative regulation of immune system process GO:0002697 regulation of immune effector process GO:0002698 negative regulation of immune effector process GO:0002703 regulation of leukocyte mediated immunity GO:0002704 negative regulation of leukocyte mediated immunity GO:0002706 regulation of lymphocyte mediated immunity GO:0002707 negative regulation of lymphocyte mediated immunity GO:0002715 regulation of natural killer cell mediated immunity GO:0002716 negative regulation of natural killer cell mediated immunity GO:0010466 negative regulation of peptidase activity GO:0010951 negative regulation of endopeptidase activity GO:0031341 regulation of cell killing GO:0031342 negative regulation of cell killing GO:0031348 negative regulation of defense response GO:0033668 negative regulation by symbiont of host apoptotic process GO:0035821 modification of morphology or physiology of other organism GO:0042267 natural killer cell mediated cytotoxicity GO:0042269 regulation of natural killer cell mediated cytotoxicity GO:0042270 protection from natural killer cell mediated cytotoxicity GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043627 response to estrogen GO:0044003 modification by symbiont of host morphology or physiology GO:0044068 modulation by symbiont of host cellular process GO:0044531 modulation of programmed cell death in other organism GO:0044532 modulation of apoptotic process in other organism GO:0045088 regulation of innate immune response GO:0045824 negative regulation of innate immune response GO:0045861 negative regulation of proteolysis GO:0045953 negative regulation of natural killer cell mediated cytotoxicity GO:0050777 negative regulation of immune response GO:0051346 negative regulation of hydrolase activity GO:0051701 interaction with host GO:0051817 modification of morphology or physiology of other organism involved in symbiotic interaction GO:0052040 modulation by symbiont of host programmed cell death GO:0052041 negative regulation by symbiont of host programmed cell death GO:0052150 modulation by symbiont of host apoptotic process GO:0052248 modulation of programmed cell death in other organism involved in symbiotic interaction GO:0052433 modulation by organism of apoptotic process in other organism involved in symbiotic interaction GO:0052490 negative regulation by organism of programmed cell death in other organism involved in symbiotic interaction GO:0052547 regulation of peptidase activity GO:0052548 regulation of endopeptidase activity GO:0071391 cellular response to estrogen stimulus GO:2000116 regulation of cysteine-type endopeptidase activity GO:2000117 negative regulation of cysteine-type endopeptidase activity |
Molecular Function |
GO:0002020 protease binding GO:0004857 enzyme inhibitor activity GO:0004866 endopeptidase inhibitor activity GO:0004867 serine-type endopeptidase inhibitor activity GO:0004869 cysteine-type endopeptidase inhibitor activity GO:0030414 peptidase inhibitor activity GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process GO:0061134 peptidase regulator activity GO:0061135 endopeptidase regulator activity |
Cellular Component | - |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | SERPINB9 |
Name | serpin peptidase inhibitor, clade B (ovalbumin), member 9 |
Aliases | CAP3; PI9; serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 9; CAP-3; PI-9; cytoplasmi ...... |
Chromosomal Location | 6p25.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between SERPINB9 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between SERPINB9 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | SERPINB9 |
Name | serpin peptidase inhibitor, clade B (ovalbumin), member 9 |
Aliases | CAP3; PI9; serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 9; CAP-3; PI-9; cytoplasmi ...... |
Chromosomal Location | 6p25.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of SERPINB9 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | SERPINB9 |
Name | serpin peptidase inhibitor, clade B (ovalbumin), member 9 |
Aliases | CAP3; PI9; serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 9; CAP-3; PI-9; cytoplasmi ...... |
Chromosomal Location | 6p25.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of SERPINB9 in various data sets.
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Points in the above scatter plot represent the mutation difference of SERPINB9 in various data sets.
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Summary | |
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Symbol | SERPINB9 |
Name | serpin peptidase inhibitor, clade B (ovalbumin), member 9 |
Aliases | CAP3; PI9; serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 9; CAP-3; PI-9; cytoplasmi ...... |
Chromosomal Location | 6p25.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SERPINB9. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | SERPINB9 |
Name | serpin peptidase inhibitor, clade B (ovalbumin), member 9 |
Aliases | CAP3; PI9; serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 9; CAP-3; PI-9; cytoplasmi ...... |
Chromosomal Location | 6p25.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SERPINB9. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SERPINB9. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | SERPINB9 |
Name | serpin peptidase inhibitor, clade B (ovalbumin), member 9 |
Aliases | CAP3; PI9; serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 9; CAP-3; PI-9; cytoplasmi ...... |
Chromosomal Location | 6p25.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SERPINB9. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | SERPINB9 |
Name | serpin peptidase inhibitor, clade B (ovalbumin), member 9 |
Aliases | CAP3; PI9; serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 9; CAP-3; PI-9; cytoplasmi ...... |
Chromosomal Location | 6p25.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of SERPINB9 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | SERPINB9 |
Name | serpin peptidase inhibitor, clade B (ovalbumin), member 9 |
Aliases | CAP3; PI9; serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 9; CAP-3; PI-9; cytoplasmi ...... |
Chromosomal Location | 6p25.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between SERPINB9 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | SERPINB9 |
Name | serpin peptidase inhibitor, clade B (ovalbumin), member 9 |
Aliases | CAP3; PI9; serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 9; CAP-3; PI-9; cytoplasmi ...... |
Chromosomal Location | 6p25.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting SERPINB9 collected from DrugBank database. |
Details on drugs targeting SERPINB9.
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