Summary | |
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Symbol | SERPINE1 |
Name | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 |
Aliases | plasminogen activator inhibitor, type I; PLANH1; PAI1; serine (or cysteine) proteinase inhibitor, clade E (n ...... |
Chromosomal Location | 7q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted |
Domain |
PF00079 Serpin (serine protease inhibitor) |
Function |
Serine protease inhibitor. Inhibits TMPRSS7 (PubMed:15853774). Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots (PubMed:8481516, PubMed:9207454, PubMed:17912461). As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading (PubMed:9175705). Acts as a regulator of cell migration, independently of its role as protease inhibitor (PubMed:15001579, PubMed:9168821). It is required for stimulation of keratinocyte migration during cutaneous injury repair (PubMed:18386027). It is involved in cellular and replicative senescence (PubMed:16862142). Plays a role in alveolar type 2 cells senescence in the lung (By similarity). Is involved in the regulation of cementogenic differentiation of periodontal ligament stem cells, and regulates odontoblast differentiation and dentin formation during odontogenesis (PubMed:25808697, PubMed:27046084). |
Biological Process |
GO:0001300 chronological cell aging GO:0001525 angiogenesis GO:0001819 positive regulation of cytokine production GO:0001952 regulation of cell-matrix adhesion GO:0001953 negative regulation of cell-matrix adhesion GO:0002237 response to molecule of bacterial origin GO:0002532 production of molecular mediator involved in inflammatory response GO:0002538 arachidonic acid metabolite production involved in inflammatory response GO:0002540 leukotriene production involved in inflammatory response GO:0002548 monocyte chemotaxis GO:0002576 platelet degranulation GO:0002685 regulation of leukocyte migration GO:0002687 positive regulation of leukocyte migration GO:0002688 regulation of leukocyte chemotaxis GO:0002690 positive regulation of leukocyte chemotaxis GO:0006887 exocytosis GO:0006898 receptor-mediated endocytosis GO:0007160 cell-matrix adhesion GO:0007162 negative regulation of cell adhesion GO:0007568 aging GO:0007569 cell aging GO:0007596 blood coagulation GO:0007599 hemostasis GO:0007623 circadian rhythm GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors GO:0010466 negative regulation of peptidase activity GO:0010469 regulation of receptor activity GO:0010755 regulation of plasminogen activation GO:0010757 negative regulation of plasminogen activation GO:0010810 regulation of cell-substrate adhesion GO:0010812 negative regulation of cell-substrate adhesion GO:0010951 negative regulation of endopeptidase activity GO:0010955 negative regulation of protein processing GO:0014812 muscle cell migration GO:0014909 smooth muscle cell migration GO:0014910 regulation of smooth muscle cell migration GO:0014912 negative regulation of smooth muscle cell migration GO:0016485 protein processing GO:0016525 negative regulation of angiogenesis GO:0030100 regulation of endocytosis GO:0030193 regulation of blood coagulation GO:0030194 positive regulation of blood coagulation GO:0030195 negative regulation of blood coagulation GO:0030198 extracellular matrix organization GO:0030335 positive regulation of cell migration GO:0030336 negative regulation of cell migration GO:0030595 leukocyte chemotaxis GO:0031349 positive regulation of defense response GO:0031589 cell-substrate adhesion GO:0031638 zymogen activation GO:0031639 plasminogen activation GO:0032102 negative regulation of response to external stimulus GO:0032103 positive regulation of response to external stimulus GO:0032496 response to lipopolysaccharide GO:0032637 interleukin-8 production GO:0032677 regulation of interleukin-8 production GO:0032757 positive regulation of interleukin-8 production GO:0033627 cell adhesion mediated by integrin GO:0033628 regulation of cell adhesion mediated by integrin GO:0033629 negative regulation of cell adhesion mediated by integrin GO:0035490 regulation of leukotriene production involved in inflammatory response GO:0035491 positive regulation of leukotriene production involved in inflammatory response GO:0040013 negative regulation of locomotion GO:0040017 positive regulation of locomotion GO:0042730 fibrinolysis GO:0042742 defense response to bacterium GO:0043062 extracellular structure organization GO:0045055 regulated exocytosis GO:0045765 regulation of angiogenesis GO:0045766 positive regulation of angiogenesis GO:0045807 positive regulation of endocytosis GO:0045861 negative regulation of proteolysis GO:0048259 regulation of receptor-mediated endocytosis GO:0048260 positive regulation of receptor-mediated endocytosis GO:0048511 rhythmic process GO:0048514 blood vessel morphogenesis GO:0050727 regulation of inflammatory response GO:0050729 positive regulation of inflammatory response GO:0050817 coagulation GO:0050818 regulation of coagulation GO:0050819 negative regulation of coagulation GO:0050820 positive regulation of coagulation GO:0050829 defense response to Gram-negative bacterium GO:0050878 regulation of body fluid levels GO:0050900 leukocyte migration GO:0050920 regulation of chemotaxis GO:0050921 positive regulation of chemotaxis GO:0051271 negative regulation of cellular component movement GO:0051272 positive regulation of cellular component movement GO:0051346 negative regulation of hydrolase activity GO:0051604 protein maturation GO:0051917 regulation of fibrinolysis GO:0051918 negative regulation of fibrinolysis GO:0052547 regulation of peptidase activity GO:0052548 regulation of endopeptidase activity GO:0060055 angiogenesis involved in wound healing GO:0060326 cell chemotaxis GO:0060627 regulation of vesicle-mediated transport GO:0061041 regulation of wound healing GO:0061042 vascular wound healing GO:0061043 regulation of vascular wound healing GO:0061044 negative regulation of vascular wound healing GO:0061045 negative regulation of wound healing GO:0061302 smooth muscle cell-matrix adhesion GO:0070613 regulation of protein processing GO:0071216 cellular response to biotic stimulus GO:0071219 cellular response to molecule of bacterial origin GO:0071222 cellular response to lipopolysaccharide GO:0071396 cellular response to lipid GO:0071674 mononuclear cell migration GO:0071675 regulation of mononuclear cell migration GO:0071677 positive regulation of mononuclear cell migration GO:0072577 endothelial cell apoptotic process GO:0090025 regulation of monocyte chemotaxis GO:0090026 positive regulation of monocyte chemotaxis GO:0090303 positive regulation of wound healing GO:0097191 extrinsic apoptotic signaling pathway GO:0097529 myeloid leukocyte migration GO:0098542 defense response to other organism GO:1900046 regulation of hemostasis GO:1900047 negative regulation of hemostasis GO:1900048 positive regulation of hemostasis GO:1901342 regulation of vasculature development GO:1901343 negative regulation of vasculature development GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1903034 regulation of response to wounding GO:1903035 negative regulation of response to wounding GO:1903036 positive regulation of response to wounding GO:1903317 regulation of protein maturation GO:1903318 negative regulation of protein maturation GO:1904018 positive regulation of vasculature development GO:1904019 epithelial cell apoptotic process GO:1904035 regulation of epithelial cell apoptotic process GO:1904036 negative regulation of epithelial cell apoptotic process GO:2000097 regulation of smooth muscle cell-matrix adhesion GO:2000098 negative regulation of smooth muscle cell-matrix adhesion GO:2000146 negative regulation of cell motility GO:2000147 positive regulation of cell motility GO:2000181 negative regulation of blood vessel morphogenesis GO:2000351 regulation of endothelial cell apoptotic process GO:2000352 negative regulation of endothelial cell apoptotic process GO:2001233 regulation of apoptotic signaling pathway GO:2001234 negative regulation of apoptotic signaling pathway GO:2001236 regulation of extrinsic apoptotic signaling pathway GO:2001237 negative regulation of extrinsic apoptotic signaling pathway |
Molecular Function |
GO:0002020 protease binding GO:0004857 enzyme inhibitor activity GO:0004866 endopeptidase inhibitor activity GO:0004867 serine-type endopeptidase inhibitor activity GO:0030414 peptidase inhibitor activity GO:0061134 peptidase regulator activity GO:0061135 endopeptidase regulator activity |
Cellular Component |
GO:0030141 secretory granule GO:0031091 platelet alpha granule GO:0031093 platelet alpha granule lumen GO:0031983 vesicle lumen GO:0034774 secretory granule lumen GO:0060205 cytoplasmic membrane-bounded vesicle lumen GO:0099503 secretory vesicle |
KEGG |
hsa04066 HIF-1 signaling pathway hsa04115 p53 signaling pathway hsa04390 Hippo signaling pathway hsa04610 Complement and coagulation cascades |
Reactome |
R-HSA-1368108: BMAL1 R-HSA-400253: Circadian Clock R-HSA-75205: Dissolution of Fibrin Clot R-HSA-3000178: ECM proteoglycans R-HSA-1474244: Extracellular matrix organization R-HSA-74160: Gene Expression R-HSA-212436: Generic Transcription Pathway R-HSA-109582: Hemostasis R-HSA-76002: Platelet activation, signaling and aggregation R-HSA-114608: Platelet degranulation R-HSA-76005: Response to elevated platelet cytosolic Ca2+ R-HSA-2173796: SMAD2/SMAD3 R-HSA-162582: Signal Transduction R-HSA-170834: Signaling by TGF-beta Receptor Complex R-HSA-2173793: Transcriptional activity of SMAD2/SMAD3 |
Summary | |
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Symbol | SERPINE1 |
Name | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 |
Aliases | plasminogen activator inhibitor, type I; PLANH1; PAI1; serine (or cysteine) proteinase inhibitor, clade E (n ...... |
Chromosomal Location | 7q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between SERPINE1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | SERPINE1 |
Name | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 |
Aliases | plasminogen activator inhibitor, type I; PLANH1; PAI1; serine (or cysteine) proteinase inhibitor, clade E (n ...... |
Chromosomal Location | 7q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of SERPINE1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | SERPINE1 |
Name | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 |
Aliases | plasminogen activator inhibitor, type I; PLANH1; PAI1; serine (or cysteine) proteinase inhibitor, clade E (n ...... |
Chromosomal Location | 7q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of SERPINE1 in various data sets.
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Points in the above scatter plot represent the mutation difference of SERPINE1 in various data sets.
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Summary | |
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Symbol | SERPINE1 |
Name | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 |
Aliases | plasminogen activator inhibitor, type I; PLANH1; PAI1; serine (or cysteine) proteinase inhibitor, clade E (n ...... |
Chromosomal Location | 7q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SERPINE1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | SERPINE1 |
Name | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 |
Aliases | plasminogen activator inhibitor, type I; PLANH1; PAI1; serine (or cysteine) proteinase inhibitor, clade E (n ...... |
Chromosomal Location | 7q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SERPINE1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SERPINE1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | SERPINE1 |
Name | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 |
Aliases | plasminogen activator inhibitor, type I; PLANH1; PAI1; serine (or cysteine) proteinase inhibitor, clade E (n ...... |
Chromosomal Location | 7q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SERPINE1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | SERPINE1 |
Name | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 |
Aliases | plasminogen activator inhibitor, type I; PLANH1; PAI1; serine (or cysteine) proteinase inhibitor, clade E (n ...... |
Chromosomal Location | 7q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of SERPINE1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | SERPINE1 |
Name | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 |
Aliases | plasminogen activator inhibitor, type I; PLANH1; PAI1; serine (or cysteine) proteinase inhibitor, clade E (n ...... |
Chromosomal Location | 7q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between SERPINE1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | SERPINE1 |
Name | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 |
Aliases | plasminogen activator inhibitor, type I; PLANH1; PAI1; serine (or cysteine) proteinase inhibitor, clade E (n ...... |
Chromosomal Location | 7q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting SERPINE1 collected from DrugBank database. |
Details on drugs targeting SERPINE1.
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