Summary | |
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Symbol | SERPINF2 |
Name | serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 |
Aliases | API; ALPHA-2-PI; A2AP; AAP; alpha-2-plasmin inhibitor; alpha-2-antiplasmin; PLI; serine (or cysteine) protei ...... |
Chromosomal Location | 17p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted. |
Domain |
PF00079 Serpin (serine protease inhibitor) |
Function |
Serine protease inhibitor. The major targets of this inhibitor are plasmin and trypsin, but it also inactivates matriptase-3/TMPRSS7 and chymotrypsin. |
Biological Process |
GO:0001819 positive regulation of cytokine production GO:0001990 regulation of systemic arterial blood pressure by hormone GO:0002034 regulation of blood vessel size by renin-angiotensin GO:0002526 acute inflammatory response GO:0002576 platelet degranulation GO:0003013 circulatory system process GO:0003014 renal system process GO:0003018 vascular process in circulatory system GO:0003044 regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003071 renal system process involved in regulation of systemic arterial blood pressure GO:0003072 renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure GO:0003073 regulation of systemic arterial blood pressure GO:0003081 regulation of systemic arterial blood pressure by renin-angiotensin GO:0006887 exocytosis GO:0006953 acute-phase response GO:0007015 actin filament organization GO:0007254 JNK cascade GO:0007596 blood coagulation GO:0007599 hemostasis GO:0008015 blood circulation GO:0008217 regulation of blood pressure GO:0010466 negative regulation of peptidase activity GO:0010712 regulation of collagen metabolic process GO:0010714 positive regulation of collagen metabolic process GO:0010755 regulation of plasminogen activation GO:0010757 negative regulation of plasminogen activation GO:0010951 negative regulation of endopeptidase activity GO:0010955 negative regulation of protein processing GO:0016485 protein processing GO:0022407 regulation of cell-cell adhesion GO:0022409 positive regulation of cell-cell adhesion GO:0030038 contractile actin filament bundle assembly GO:0030193 regulation of blood coagulation GO:0030194 positive regulation of blood coagulation GO:0030195 negative regulation of blood coagulation GO:0030198 extracellular matrix organization GO:0030199 collagen fibril organization GO:0031032 actomyosin structure organization GO:0031098 stress-activated protein kinase signaling cascade GO:0031638 zymogen activation GO:0031639 plasminogen activation GO:0032102 negative regulation of response to external stimulus GO:0032103 positive regulation of response to external stimulus GO:0032231 regulation of actin filament bundle assembly GO:0032233 positive regulation of actin filament bundle assembly GO:0032872 regulation of stress-activated MAPK cascade GO:0032874 positive regulation of stress-activated MAPK cascade GO:0032956 regulation of actin cytoskeleton organization GO:0032963 collagen metabolic process GO:0032964 collagen biosynthetic process GO:0032965 regulation of collagen biosynthetic process GO:0032967 positive regulation of collagen biosynthetic process GO:0032970 regulation of actin filament-based process GO:0033002 muscle cell proliferation GO:0035150 regulation of tube size GO:0042730 fibrinolysis GO:0043062 extracellular structure organization GO:0043149 stress fiber assembly GO:0043410 positive regulation of MAPK cascade GO:0044089 positive regulation of cellular component biogenesis GO:0044236 multicellular organism metabolic process GO:0044246 regulation of multicellular organismal metabolic process GO:0044253 positive regulation of multicellular organismal metabolic process GO:0044259 multicellular organismal macromolecule metabolic process GO:0044331 cell-cell adhesion mediated by cadherin GO:0045055 regulated exocytosis GO:0045785 positive regulation of cell adhesion GO:0045861 negative regulation of proteolysis GO:0046328 regulation of JNK cascade GO:0046330 positive regulation of JNK cascade GO:0048514 blood vessel morphogenesis GO:0048659 smooth muscle cell proliferation GO:0048660 regulation of smooth muscle cell proliferation GO:0048661 positive regulation of smooth muscle cell proliferation GO:0050817 coagulation GO:0050818 regulation of coagulation GO:0050819 negative regulation of coagulation GO:0050820 positive regulation of coagulation GO:0050878 regulation of body fluid levels GO:0050880 regulation of blood vessel size GO:0050886 endocrine process GO:0051017 actin filament bundle assembly GO:0051346 negative regulation of hydrolase activity GO:0051403 stress-activated MAPK cascade GO:0051492 regulation of stress fiber assembly GO:0051493 regulation of cytoskeleton organization GO:0051495 positive regulation of cytoskeleton organization GO:0051496 positive regulation of stress fiber assembly GO:0051604 protein maturation GO:0051917 regulation of fibrinolysis GO:0051918 negative regulation of fibrinolysis GO:0052547 regulation of peptidase activity GO:0052548 regulation of endopeptidase activity GO:0061041 regulation of wound healing GO:0061045 negative regulation of wound healing GO:0061572 actin filament bundle organization GO:0070302 regulation of stress-activated protein kinase signaling cascade GO:0070304 positive regulation of stress-activated protein kinase signaling cascade GO:0070371 ERK1 and ERK2 cascade GO:0070372 regulation of ERK1 and ERK2 cascade GO:0070374 positive regulation of ERK1 and ERK2 cascade GO:0070613 regulation of protein processing GO:0071604 transforming growth factor beta production GO:0071634 regulation of transforming growth factor beta production GO:0071636 positive regulation of transforming growth factor beta production GO:0090066 regulation of anatomical structure size GO:0090303 positive regulation of wound healing GO:1900046 regulation of hemostasis GO:1900047 negative regulation of hemostasis GO:1900048 positive regulation of hemostasis GO:1903034 regulation of response to wounding GO:1903035 negative regulation of response to wounding GO:1903036 positive regulation of response to wounding GO:1903317 regulation of protein maturation GO:1903318 negative regulation of protein maturation GO:2000047 regulation of cell-cell adhesion mediated by cadherin GO:2000049 positive regulation of cell-cell adhesion mediated by cadherin |
Molecular Function |
GO:0002020 protease binding GO:0004857 enzyme inhibitor activity GO:0004866 endopeptidase inhibitor activity GO:0004867 serine-type endopeptidase inhibitor activity GO:0030414 peptidase inhibitor activity GO:0061134 peptidase regulator activity GO:0061135 endopeptidase regulator activity |
Cellular Component |
GO:0005577 fibrinogen complex GO:0030141 secretory granule GO:0031091 platelet alpha granule GO:0031093 platelet alpha granule lumen GO:0031983 vesicle lumen GO:0034774 secretory granule lumen GO:0060205 cytoplasmic membrane-bounded vesicle lumen GO:0072562 blood microparticle GO:0099503 secretory vesicle |
KEGG |
hsa04610 Complement and coagulation cascades |
Reactome |
R-HSA-75205: Dissolution of Fibrin Clot R-HSA-109582: Hemostasis R-HSA-76002: Platelet activation, signaling and aggregation R-HSA-114608: Platelet degranulation R-HSA-76005: Response to elevated platelet cytosolic Ca2+ |
Summary | |
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Symbol | SERPINF2 |
Name | serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 |
Aliases | API; ALPHA-2-PI; A2AP; AAP; alpha-2-plasmin inhibitor; alpha-2-antiplasmin; PLI; serine (or cysteine) protei ...... |
Chromosomal Location | 17p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between SERPINF2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | SERPINF2 |
Name | serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 |
Aliases | API; ALPHA-2-PI; A2AP; AAP; alpha-2-plasmin inhibitor; alpha-2-antiplasmin; PLI; serine (or cysteine) protei ...... |
Chromosomal Location | 17p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of SERPINF2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | SERPINF2 |
Name | serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 |
Aliases | API; ALPHA-2-PI; A2AP; AAP; alpha-2-plasmin inhibitor; alpha-2-antiplasmin; PLI; serine (or cysteine) protei ...... |
Chromosomal Location | 17p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of SERPINF2 in various data sets.
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Points in the above scatter plot represent the mutation difference of SERPINF2 in various data sets.
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Summary | |
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Symbol | SERPINF2 |
Name | serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 |
Aliases | API; ALPHA-2-PI; A2AP; AAP; alpha-2-plasmin inhibitor; alpha-2-antiplasmin; PLI; serine (or cysteine) protei ...... |
Chromosomal Location | 17p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SERPINF2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | SERPINF2 |
Name | serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 |
Aliases | API; ALPHA-2-PI; A2AP; AAP; alpha-2-plasmin inhibitor; alpha-2-antiplasmin; PLI; serine (or cysteine) protei ...... |
Chromosomal Location | 17p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SERPINF2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SERPINF2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | SERPINF2 |
Name | serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 |
Aliases | API; ALPHA-2-PI; A2AP; AAP; alpha-2-plasmin inhibitor; alpha-2-antiplasmin; PLI; serine (or cysteine) protei ...... |
Chromosomal Location | 17p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SERPINF2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | SERPINF2 |
Name | serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 |
Aliases | API; ALPHA-2-PI; A2AP; AAP; alpha-2-plasmin inhibitor; alpha-2-antiplasmin; PLI; serine (or cysteine) protei ...... |
Chromosomal Location | 17p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of SERPINF2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | SERPINF2 |
Name | serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 |
Aliases | API; ALPHA-2-PI; A2AP; AAP; alpha-2-plasmin inhibitor; alpha-2-antiplasmin; PLI; serine (or cysteine) protei ...... |
Chromosomal Location | 17p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between SERPINF2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | SERPINF2 |
Name | serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 |
Aliases | API; ALPHA-2-PI; A2AP; AAP; alpha-2-plasmin inhibitor; alpha-2-antiplasmin; PLI; serine (or cysteine) protei ...... |
Chromosomal Location | 17p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting SERPINF2 collected from DrugBank database. |
Details on drugs targeting SERPINF2.
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