Summary | |
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Symbol | SFRP2 |
Name | secreted frizzled-related protein 2 |
Aliases | SARP1; SDF-5; SARP-1; sFRP-2; secreted apoptosis related protein 1; secreted apoptosis-related protein 1 |
Chromosomal Location | 4q31.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted |
Domain |
PF01392 Fz domain PF01759 UNC-6/NTR/C345C module |
Function |
Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP2 may be important for eye retinal development and for myogenesis. |
Biological Process |
GO:0001501 skeletal system development GO:0001503 ossification GO:0001525 angiogenesis GO:0001558 regulation of cell growth GO:0001569 patterning of blood vessels GO:0001649 osteoblast differentiation GO:0001704 formation of primary germ layer GO:0001707 mesoderm formation GO:0001708 cell fate specification GO:0001710 mesodermal cell fate commitment GO:0001736 establishment of planar polarity GO:0001738 morphogenesis of a polarized epithelium GO:0001756 somitogenesis GO:0001763 morphogenesis of a branching structure GO:0001837 epithelial to mesenchymal transition GO:0001838 embryonic epithelial tube formation GO:0001841 neural tube formation GO:0001843 neural tube closure GO:0001933 negative regulation of protein phosphorylation GO:0002062 chondrocyte differentiation GO:0002063 chondrocyte development GO:0003002 regionalization GO:0003007 heart morphogenesis GO:0003151 outflow tract morphogenesis GO:0003205 cardiac chamber development GO:0003206 cardiac chamber morphogenesis GO:0003208 cardiac ventricle morphogenesis GO:0003214 cardiac left ventricle morphogenesis GO:0003231 cardiac ventricle development GO:0003401 axis elongation GO:0003402 planar cell polarity pathway involved in axis elongation GO:0006469 negative regulation of protein kinase activity GO:0006606 protein import into nucleus GO:0006913 nucleocytoplasmic transport GO:0007164 establishment of tissue polarity GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007254 JNK cascade GO:0007369 gastrulation GO:0007389 pattern specification process GO:0007498 mesoderm development GO:0007501 mesodermal cell fate specification GO:0007507 heart development GO:0007548 sex differentiation GO:0007584 response to nutrient GO:0008406 gonad development GO:0008584 male gonad development GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage GO:0009314 response to radiation GO:0009952 anterior/posterior pattern specification GO:0009991 response to extracellular stimulus GO:0009996 negative regulation of cell fate specification GO:0010165 response to X-ray GO:0010212 response to ionizing radiation GO:0010453 regulation of cell fate commitment GO:0010454 negative regulation of cell fate commitment GO:0010466 negative regulation of peptidase activity GO:0010470 regulation of gastrulation GO:0010656 negative regulation of muscle cell apoptotic process GO:0010657 muscle cell apoptotic process GO:0010658 striated muscle cell apoptotic process GO:0010659 cardiac muscle cell apoptotic process GO:0010660 regulation of muscle cell apoptotic process GO:0010662 regulation of striated muscle cell apoptotic process GO:0010664 negative regulation of striated muscle cell apoptotic process GO:0010665 regulation of cardiac muscle cell apoptotic process GO:0010667 negative regulation of cardiac muscle cell apoptotic process GO:0010717 regulation of epithelial to mesenchymal transition GO:0010719 negative regulation of epithelial to mesenchymal transition GO:0010950 positive regulation of endopeptidase activity GO:0010951 negative regulation of endopeptidase activity GO:0010952 positive regulation of peptidase activity GO:0010975 regulation of neuron projection development GO:0014020 primary neural tube formation GO:0016049 cell growth GO:0016055 Wnt signaling pathway GO:0016331 morphogenesis of embryonic epithelium GO:0017038 protein import GO:0017145 stem cell division GO:0018105 peptidyl-serine phosphorylation GO:0018108 peptidyl-tyrosine phosphorylation GO:0018209 peptidyl-serine modification GO:0018212 peptidyl-tyrosine modification GO:0021915 neural tube development GO:0021953 central nervous system neuron differentiation GO:0030111 regulation of Wnt signaling pathway GO:0030177 positive regulation of Wnt signaling pathway GO:0030178 negative regulation of Wnt signaling pathway GO:0030198 extracellular matrix organization GO:0030199 collagen fibril organization GO:0030278 regulation of ossification GO:0030307 positive regulation of cell growth GO:0030308 negative regulation of cell growth GO:0030326 embryonic limb morphogenesis GO:0030336 negative regulation of cell migration GO:0030509 BMP signaling pathway GO:0030510 regulation of BMP signaling pathway GO:0030514 negative regulation of BMP signaling pathway GO:0030901 midbrain development GO:0031098 stress-activated protein kinase signaling cascade GO:0031667 response to nutrient levels GO:0031668 cellular response to extracellular stimulus GO:0032386 regulation of intracellular transport GO:0032388 positive regulation of intracellular transport GO:0032872 regulation of stress-activated MAPK cascade GO:0032873 negative regulation of stress-activated MAPK cascade GO:0033135 regulation of peptidyl-serine phosphorylation GO:0033138 positive regulation of peptidyl-serine phosphorylation GO:0033157 regulation of intracellular protein transport GO:0033627 cell adhesion mediated by integrin GO:0033628 regulation of cell adhesion mediated by integrin GO:0033630 positive regulation of cell adhesion mediated by integrin GO:0033673 negative regulation of kinase activity GO:0034504 protein localization to nucleus GO:0035107 appendage morphogenesis GO:0035108 limb morphogenesis GO:0035113 embryonic appendage morphogenesis GO:0035148 tube formation GO:0035239 tube morphogenesis GO:0035282 segmentation GO:0035411 catenin import into nucleus GO:0035412 regulation of catenin import into nucleus GO:0035413 positive regulation of catenin import into nucleus GO:0035567 non-canonical Wnt signaling pathway GO:0036342 post-anal tail morphogenesis GO:0040013 negative regulation of locomotion GO:0042249 establishment of planar polarity of embryonic epithelium GO:0042306 regulation of protein import into nucleus GO:0042307 positive regulation of protein import into nucleus GO:0042326 negative regulation of phosphorylation GO:0042493 response to drug GO:0042659 regulation of cell fate specification GO:0042661 regulation of mesodermal cell fate specification GO:0042662 negative regulation of mesodermal cell fate specification GO:0042733 embryonic digit morphogenesis GO:0043062 extracellular structure organization GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043405 regulation of MAP kinase activity GO:0043407 negative regulation of MAP kinase activity GO:0043409 negative regulation of MAPK cascade GO:0043506 regulation of JUN kinase activity GO:0043508 negative regulation of JUN kinase activity GO:0044744 protein targeting to nucleus GO:0045137 development of primary sexual characteristics GO:0045165 cell fate commitment GO:0045444 fat cell differentiation GO:0045598 regulation of fat cell differentiation GO:0045600 positive regulation of fat cell differentiation GO:0045667 regulation of osteoblast differentiation GO:0045669 positive regulation of osteoblast differentiation GO:0045765 regulation of angiogenesis GO:0045766 positive regulation of angiogenesis GO:0045778 positive regulation of ossification GO:0045785 positive regulation of cell adhesion GO:0045861 negative regulation of proteolysis GO:0045862 positive regulation of proteolysis GO:0045926 negative regulation of growth GO:0045927 positive regulation of growth GO:0045992 negative regulation of embryonic development GO:0045995 regulation of embryonic development GO:0046328 regulation of JNK cascade GO:0046329 negative regulation of JNK cascade GO:0046546 development of primary male sexual characteristics GO:0046661 male sex differentiation GO:0046822 regulation of nucleocytoplasmic transport GO:0046824 positive regulation of nucleocytoplasmic transport GO:0048332 mesoderm morphogenesis GO:0048333 mesodermal cell differentiation GO:0048514 blood vessel morphogenesis GO:0048546 digestive tract morphogenesis GO:0048565 digestive tract development GO:0048608 reproductive structure development GO:0048638 regulation of developmental growth GO:0048640 negative regulation of developmental growth GO:0048705 skeletal system morphogenesis GO:0048736 appendage development GO:0048754 branching morphogenesis of an epithelial tube GO:0048762 mesenchymal cell differentiation GO:0050673 epithelial cell proliferation GO:0050678 regulation of epithelial cell proliferation GO:0050680 negative regulation of epithelial cell proliferation GO:0050730 regulation of peptidyl-tyrosine phosphorylation GO:0050732 negative regulation of peptidyl-tyrosine phosphorylation GO:0051169 nuclear transport GO:0051170 nuclear import GO:0051216 cartilage development GO:0051222 positive regulation of protein transport GO:0051271 negative regulation of cellular component movement GO:0051302 regulation of cell division GO:0051346 negative regulation of hydrolase activity GO:0051348 negative regulation of transferase activity GO:0051403 stress-activated MAPK cascade GO:0052547 regulation of peptidase activity GO:0052548 regulation of endopeptidase activity GO:0055123 digestive system development GO:0060026 convergent extension GO:0060028 convergent extension involved in axis elongation GO:0060070 canonical Wnt signaling pathway GO:0060071 Wnt signaling pathway, planar cell polarity pathway GO:0060173 limb development GO:0060348 bone development GO:0060349 bone morphogenesis GO:0060485 mesenchyme development GO:0060560 developmental growth involved in morphogenesis GO:0060562 epithelial tube morphogenesis GO:0060606 tube closure GO:0060795 cell fate commitment involved in formation of primary germ layer GO:0060828 regulation of canonical Wnt signaling pathway GO:0061053 somite development GO:0061054 dermatome development GO:0061056 sclerotome development GO:0061138 morphogenesis of a branching epithelium GO:0061183 regulation of dermatome development GO:0061185 negative regulation of dermatome development GO:0061448 connective tissue development GO:0061458 reproductive system development GO:0070302 regulation of stress-activated protein kinase signaling cascade GO:0070303 negative regulation of stress-activated protein kinase signaling cascade GO:0071214 cellular response to abiotic stimulus GO:0071425 hematopoietic stem cell proliferation GO:0071478 cellular response to radiation GO:0071479 cellular response to ionizing radiation GO:0071481 cellular response to X-ray GO:0071496 cellular response to external stimulus GO:0071542 dopaminergic neuron differentiation GO:0071772 response to BMP GO:0071773 cellular response to BMP stimulus GO:0071900 regulation of protein serine/threonine kinase activity GO:0071901 negative regulation of protein serine/threonine kinase activity GO:0072089 stem cell proliferation GO:0072175 epithelial tube formation GO:0090090 negative regulation of canonical Wnt signaling pathway GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway GO:0090101 negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway GO:0090175 regulation of establishment of planar polarity GO:0090177 establishment of planar polarity involved in neural tube closure GO:0090178 regulation of establishment of planar polarity involved in neural tube closure GO:0090179 planar cell polarity pathway involved in neural tube closure GO:0090244 Wnt signaling pathway involved in somitogenesis GO:0090263 positive regulation of canonical Wnt signaling pathway GO:0090287 regulation of cellular response to growth factor stimulus GO:0090288 negative regulation of cellular response to growth factor stimulus GO:0090316 positive regulation of intracellular protein transport GO:0097191 extrinsic apoptotic signaling pathway GO:0097193 intrinsic apoptotic signaling pathway GO:0198738 cell-cell signaling by wnt GO:1900180 regulation of protein localization to nucleus GO:1900182 positive regulation of protein localization to nucleus GO:1901342 regulation of vasculature development GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902229 regulation of intrinsic apoptotic signaling pathway in response to DNA damage GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage GO:1902532 negative regulation of intracellular signal transduction GO:1902593 single-organism nuclear import GO:1903533 regulation of protein targeting GO:1903829 positive regulation of cellular protein localization GO:1904018 positive regulation of vasculature development GO:1904338 regulation of dopaminergic neuron differentiation GO:1904589 regulation of protein import GO:1904591 positive regulation of protein import GO:1904948 midbrain dopaminergic neuron differentiation GO:1904951 positive regulation of establishment of protein localization GO:1904956 regulation of midbrain dopaminergic neuron differentiation GO:1905276 regulation of epithelial tube formation GO:1905330 regulation of morphogenesis of an epithelium GO:2000027 regulation of organ morphogenesis GO:2000035 regulation of stem cell division GO:2000040 regulation of planar cell polarity pathway involved in axis elongation GO:2000041 negative regulation of planar cell polarity pathway involved in axis elongation GO:2000050 regulation of non-canonical Wnt signaling pathway GO:2000051 negative regulation of non-canonical Wnt signaling pathway GO:2000095 regulation of Wnt signaling pathway, planar cell polarity pathway GO:2000116 regulation of cysteine-type endopeptidase activity GO:2000117 negative regulation of cysteine-type endopeptidase activity GO:2000146 negative regulation of cell motility GO:2000380 regulation of mesoderm development GO:2000381 negative regulation of mesoderm development GO:2000542 negative regulation of gastrulation GO:2001020 regulation of response to DNA damage stimulus GO:2001021 negative regulation of response to DNA damage stimulus GO:2001233 regulation of apoptotic signaling pathway GO:2001234 negative regulation of apoptotic signaling pathway GO:2001236 regulation of extrinsic apoptotic signaling pathway GO:2001237 negative regulation of extrinsic apoptotic signaling pathway GO:2001242 regulation of intrinsic apoptotic signaling pathway GO:2001243 negative regulation of intrinsic apoptotic signaling pathway |
Molecular Function |
GO:0001968 fibronectin binding GO:0005178 integrin binding GO:0008047 enzyme activator activity GO:0016504 peptidase activator activity GO:0017147 Wnt-protein binding GO:0030545 receptor regulator activity GO:0030546 receptor activator activity GO:0042813 Wnt-activated receptor activity GO:0048018 receptor agonist activity GO:0050839 cell adhesion molecule binding GO:0061133 endopeptidase activator activity GO:0061134 peptidase regulator activity GO:0061135 endopeptidase regulator activity |
Cellular Component | - |
KEGG |
hsa04310 Wnt signaling pathway |
Reactome |
R-HSA-3772470: Negative regulation of TCF-dependent signaling by WNT ligand antagonists R-HSA-162582: Signal Transduction R-HSA-195721: Signaling by Wnt R-HSA-201681: TCF dependent signaling in response to WNT |
Summary | |
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Symbol | SFRP2 |
Name | secreted frizzled-related protein 2 |
Aliases | SARP1; SDF-5; SARP-1; sFRP-2; secreted apoptosis related protein 1; secreted apoptosis-related protein 1 |
Chromosomal Location | 4q31.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between SFRP2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | SFRP2 |
Name | secreted frizzled-related protein 2 |
Aliases | SARP1; SDF-5; SARP-1; sFRP-2; secreted apoptosis related protein 1; secreted apoptosis-related protein 1 |
Chromosomal Location | 4q31.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of SFRP2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | SFRP2 |
Name | secreted frizzled-related protein 2 |
Aliases | SARP1; SDF-5; SARP-1; sFRP-2; secreted apoptosis related protein 1; secreted apoptosis-related protein 1 |
Chromosomal Location | 4q31.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of SFRP2 in various data sets.
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Points in the above scatter plot represent the mutation difference of SFRP2 in various data sets.
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Summary | |
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Symbol | SFRP2 |
Name | secreted frizzled-related protein 2 |
Aliases | SARP1; SDF-5; SARP-1; sFRP-2; secreted apoptosis related protein 1; secreted apoptosis-related protein 1 |
Chromosomal Location | 4q31.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SFRP2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | SFRP2 |
Name | secreted frizzled-related protein 2 |
Aliases | SARP1; SDF-5; SARP-1; sFRP-2; secreted apoptosis related protein 1; secreted apoptosis-related protein 1 |
Chromosomal Location | 4q31.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SFRP2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SFRP2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | SFRP2 |
Name | secreted frizzled-related protein 2 |
Aliases | SARP1; SDF-5; SARP-1; sFRP-2; secreted apoptosis related protein 1; secreted apoptosis-related protein 1 |
Chromosomal Location | 4q31.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SFRP2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | SFRP2 |
Name | secreted frizzled-related protein 2 |
Aliases | SARP1; SDF-5; SARP-1; sFRP-2; secreted apoptosis related protein 1; secreted apoptosis-related protein 1 |
Chromosomal Location | 4q31.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of SFRP2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | SFRP2 |
Name | secreted frizzled-related protein 2 |
Aliases | SARP1; SDF-5; SARP-1; sFRP-2; secreted apoptosis related protein 1; secreted apoptosis-related protein 1 |
Chromosomal Location | 4q31.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between SFRP2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | SFRP2 |
Name | secreted frizzled-related protein 2 |
Aliases | SARP1; SDF-5; SARP-1; sFRP-2; secreted apoptosis related protein 1; secreted apoptosis-related protein 1 |
Chromosomal Location | 4q31.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting SFRP2 collected from DrugBank database. |
There is no record. |