Summary | |
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Symbol | SGCA |
Name | sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein) |
Aliases | SCARMD1; LGMD2D; adhalin; DMDA2; 50kD DAG; Sarcoglycan, alpha (50kD dystrophin-associated glycoprotein; adha ...... |
Chromosomal Location | 17q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane, sarcolemma Single-pass type I membrane protein Cytoplasm, cytoskeleton |
Domain |
PF05510 Sarcoglycan alpha/epsilon |
Function |
Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. |
Biological Process |
GO:0003012 muscle system process GO:0006936 muscle contraction GO:0007517 muscle organ development |
Molecular Function | - |
Cellular Component |
GO:0016010 dystrophin-associated glycoprotein complex GO:0016011 dystroglycan complex GO:0016012 sarcoglycan complex GO:0042383 sarcolemma GO:0045121 membrane raft GO:0090665 glycoprotein complex GO:0098589 membrane region GO:0098857 membrane microdomain |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | SGCA |
Name | sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein) |
Aliases | SCARMD1; LGMD2D; adhalin; DMDA2; 50kD DAG; Sarcoglycan, alpha (50kD dystrophin-associated glycoprotein; adha ...... |
Chromosomal Location | 17q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between SGCA and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | SGCA |
Name | sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein) |
Aliases | SCARMD1; LGMD2D; adhalin; DMDA2; 50kD DAG; Sarcoglycan, alpha (50kD dystrophin-associated glycoprotein; adha ...... |
Chromosomal Location | 17q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of SGCA in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | SGCA |
Name | sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein) |
Aliases | SCARMD1; LGMD2D; adhalin; DMDA2; 50kD DAG; Sarcoglycan, alpha (50kD dystrophin-associated glycoprotein; adha ...... |
Chromosomal Location | 17q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of SGCA in various data sets.
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Points in the above scatter plot represent the mutation difference of SGCA in various data sets.
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Summary | |
---|---|
Symbol | SGCA |
Name | sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein) |
Aliases | SCARMD1; LGMD2D; adhalin; DMDA2; 50kD DAG; Sarcoglycan, alpha (50kD dystrophin-associated glycoprotein; adha ...... |
Chromosomal Location | 17q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SGCA. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | SGCA |
Name | sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein) |
Aliases | SCARMD1; LGMD2D; adhalin; DMDA2; 50kD DAG; Sarcoglycan, alpha (50kD dystrophin-associated glycoprotein; adha ...... |
Chromosomal Location | 17q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SGCA. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SGCA. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | SGCA |
Name | sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein) |
Aliases | SCARMD1; LGMD2D; adhalin; DMDA2; 50kD DAG; Sarcoglycan, alpha (50kD dystrophin-associated glycoprotein; adha ...... |
Chromosomal Location | 17q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SGCA. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | SGCA |
Name | sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein) |
Aliases | SCARMD1; LGMD2D; adhalin; DMDA2; 50kD DAG; Sarcoglycan, alpha (50kD dystrophin-associated glycoprotein; adha ...... |
Chromosomal Location | 17q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of SGCA expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | SGCA |
Name | sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein) |
Aliases | SCARMD1; LGMD2D; adhalin; DMDA2; 50kD DAG; Sarcoglycan, alpha (50kD dystrophin-associated glycoprotein; adha ...... |
Chromosomal Location | 17q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between SGCA and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | SGCA |
Name | sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein) |
Aliases | SCARMD1; LGMD2D; adhalin; DMDA2; 50kD DAG; Sarcoglycan, alpha (50kD dystrophin-associated glycoprotein; adha ...... |
Chromosomal Location | 17q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting SGCA collected from DrugBank database. |
There is no record. |