Summary | |
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Symbol | SGPP2 |
Name | sphingosine-1-phosphate phosphatase 2 |
Aliases | FLJ39004; SPPase2; hSPP2; sphingosine 1-phosphate phosphohydrolase 2; sphingosine-1-phosphatase 2; sphingosi ...... |
Chromosomal Location | 2q36.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Endoplasmic reticulum membrane Multi-pass membrane protein |
Domain |
PF01569 PAP2 superfamily |
Function |
Has specific phosphohydrolase activity towards sphingoid base 1-phosphates. Has high phosphohydrolase activity against dihydrosphingosine-1-phosphate and sphingosine-1-phosphate (S1P) in vitro. May play a role in attenuating intracellular sphingosine 1-phosphate (S1P) signaling. May play a role in pro-inflammatory signaling. |
Biological Process |
GO:0006066 alcohol metabolic process GO:0006643 membrane lipid metabolic process GO:0006665 sphingolipid metabolic process GO:0006670 sphingosine metabolic process GO:0016311 dephosphorylation GO:0019751 polyol metabolic process GO:0030148 sphingolipid biosynthetic process GO:0034311 diol metabolic process GO:0046467 membrane lipid biosynthetic process GO:0046519 sphingoid metabolic process GO:1901615 organic hydroxy compound metabolic process |
Molecular Function |
GO:0016791 phosphatase activity GO:0042392 sphingosine-1-phosphate phosphatase activity GO:0042578 phosphoric ester hydrolase activity GO:0070780 dihydrosphingosine-1-phosphate phosphatase activity |
Cellular Component | - |
KEGG |
hsa04071 Sphingolipid signaling pathway hsa00600 Sphingolipid metabolism |
Reactome |
R-HSA-1430728: Metabolism R-HSA-556833: Metabolism of lipids and lipoproteins R-HSA-1660661: Sphingolipid de novo biosynthesis R-HSA-428157: Sphingolipid metabolism |
Summary | |
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Symbol | SGPP2 |
Name | sphingosine-1-phosphate phosphatase 2 |
Aliases | FLJ39004; SPPase2; hSPP2; sphingosine 1-phosphate phosphohydrolase 2; sphingosine-1-phosphatase 2; sphingosi ...... |
Chromosomal Location | 2q36.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between SGPP2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | SGPP2 |
Name | sphingosine-1-phosphate phosphatase 2 |
Aliases | FLJ39004; SPPase2; hSPP2; sphingosine 1-phosphate phosphohydrolase 2; sphingosine-1-phosphatase 2; sphingosi ...... |
Chromosomal Location | 2q36.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of SGPP2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | SGPP2 |
Name | sphingosine-1-phosphate phosphatase 2 |
Aliases | FLJ39004; SPPase2; hSPP2; sphingosine 1-phosphate phosphohydrolase 2; sphingosine-1-phosphatase 2; sphingosi ...... |
Chromosomal Location | 2q36.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of SGPP2 in various data sets.
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Points in the above scatter plot represent the mutation difference of SGPP2 in various data sets.
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Summary | |
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Symbol | SGPP2 |
Name | sphingosine-1-phosphate phosphatase 2 |
Aliases | FLJ39004; SPPase2; hSPP2; sphingosine 1-phosphate phosphohydrolase 2; sphingosine-1-phosphatase 2; sphingosi ...... |
Chromosomal Location | 2q36.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SGPP2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | SGPP2 |
Name | sphingosine-1-phosphate phosphatase 2 |
Aliases | FLJ39004; SPPase2; hSPP2; sphingosine 1-phosphate phosphohydrolase 2; sphingosine-1-phosphatase 2; sphingosi ...... |
Chromosomal Location | 2q36.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SGPP2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SGPP2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | SGPP2 |
Name | sphingosine-1-phosphate phosphatase 2 |
Aliases | FLJ39004; SPPase2; hSPP2; sphingosine 1-phosphate phosphohydrolase 2; sphingosine-1-phosphatase 2; sphingosi ...... |
Chromosomal Location | 2q36.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SGPP2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | SGPP2 |
Name | sphingosine-1-phosphate phosphatase 2 |
Aliases | FLJ39004; SPPase2; hSPP2; sphingosine 1-phosphate phosphohydrolase 2; sphingosine-1-phosphatase 2; sphingosi ...... |
Chromosomal Location | 2q36.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of SGPP2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | SGPP2 |
Name | sphingosine-1-phosphate phosphatase 2 |
Aliases | FLJ39004; SPPase2; hSPP2; sphingosine 1-phosphate phosphohydrolase 2; sphingosine-1-phosphatase 2; sphingosi ...... |
Chromosomal Location | 2q36.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between SGPP2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | SGPP2 |
Name | sphingosine-1-phosphate phosphatase 2 |
Aliases | FLJ39004; SPPase2; hSPP2; sphingosine 1-phosphate phosphohydrolase 2; sphingosine-1-phosphatase 2; sphingosi ...... |
Chromosomal Location | 2q36.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting SGPP2 collected from DrugBank database. |
There is no record. |