Summary | |
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Symbol | SHISA6 |
Name | shisa family member 6 |
Aliases | FLJ45455; shisa homolog 6 (Xenopus laevis); shisa homolog 6; Protein shisa-6 homolog |
Chromosomal Location | 17p13.1-p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Membrane Single-pass type I membrane protein Cell junction, synapse, postsynaptic cell membrane, postsynaptic density |
Domain |
PF13908 Wnt and FGF inhibitory regulator |
Function |
Involved in maintenance of high-frequency synaptic transmission at hippocampal CA3-CA1 synapses. Regulates AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic density keeping the channels in an activated state in the presence of glutamate and preventing synaptic depression. May play a role in self-renewal and differentiation of spermatogonial stem cells by inhibiting canonical Wnt signaling pathway. |
Biological Process |
GO:0048167 regulation of synaptic plasticity GO:0048168 regulation of neuronal synaptic plasticity GO:0048172 regulation of short-term neuronal synaptic plasticity GO:0050804 modulation of synaptic transmission |
Molecular Function | - |
Cellular Component |
GO:0008328 ionotropic glutamate receptor complex GO:0032281 AMPA glutamate receptor complex GO:0034702 ion channel complex GO:0043235 receptor complex GO:0098802 plasma membrane receptor complex GO:0098878 neurotransmitter receptor complex GO:1902495 transmembrane transporter complex GO:1990351 transporter complex |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | SHISA6 |
Name | shisa family member 6 |
Aliases | FLJ45455; shisa homolog 6 (Xenopus laevis); shisa homolog 6; Protein shisa-6 homolog |
Chromosomal Location | 17p13.1-p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between SHISA6 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | SHISA6 |
Name | shisa family member 6 |
Aliases | FLJ45455; shisa homolog 6 (Xenopus laevis); shisa homolog 6; Protein shisa-6 homolog |
Chromosomal Location | 17p13.1-p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of SHISA6 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | SHISA6 |
Name | shisa family member 6 |
Aliases | FLJ45455; shisa homolog 6 (Xenopus laevis); shisa homolog 6; Protein shisa-6 homolog |
Chromosomal Location | 17p13.1-p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of SHISA6 in various data sets.
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Points in the above scatter plot represent the mutation difference of SHISA6 in various data sets.
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Summary | |
---|---|
Symbol | SHISA6 |
Name | shisa family member 6 |
Aliases | FLJ45455; shisa homolog 6 (Xenopus laevis); shisa homolog 6; Protein shisa-6 homolog |
Chromosomal Location | 17p13.1-p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SHISA6. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | SHISA6 |
Name | shisa family member 6 |
Aliases | FLJ45455; shisa homolog 6 (Xenopus laevis); shisa homolog 6; Protein shisa-6 homolog |
Chromosomal Location | 17p13.1-p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SHISA6. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SHISA6. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | SHISA6 |
Name | shisa family member 6 |
Aliases | FLJ45455; shisa homolog 6 (Xenopus laevis); shisa homolog 6; Protein shisa-6 homolog |
Chromosomal Location | 17p13.1-p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SHISA6. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | SHISA6 |
Name | shisa family member 6 |
Aliases | FLJ45455; shisa homolog 6 (Xenopus laevis); shisa homolog 6; Protein shisa-6 homolog |
Chromosomal Location | 17p13.1-p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of SHISA6 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | SHISA6 |
Name | shisa family member 6 |
Aliases | FLJ45455; shisa homolog 6 (Xenopus laevis); shisa homolog 6; Protein shisa-6 homolog |
Chromosomal Location | 17p13.1-p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between SHISA6 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | SHISA6 |
Name | shisa family member 6 |
Aliases | FLJ45455; shisa homolog 6 (Xenopus laevis); shisa homolog 6; Protein shisa-6 homolog |
Chromosomal Location | 17p13.1-p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting SHISA6 collected from DrugBank database. |
There is no record. |