Summary | |
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Symbol | SIRPA |
Name | signal-regulatory protein alpha |
Aliases | SHPS1; SIRP; MYD-1; BIT; SHPS-1; SIRPalpha; CD172a; SIRPalpha2; MFR; SIRP-ALPHA-1; PTPNS1; protein tyrosine ...... |
Chromosomal Location | 20p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Membrane; Single-pass type I membrane protein. |
Domain |
PF07654 Immunoglobulin C1-set domain PF07686 Immunoglobulin V-set domain |
Function |
Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function (By similarity). Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. |
Biological Process |
GO:0050900 leukocyte migration |
Molecular Function |
GO:0017124 SH3 domain binding |
Cellular Component | - |
KEGG |
hsa04380 Osteoclast differentiation |
Reactome |
R-HSA-202733: Cell surface interactions at the vascular wall R-HSA-1500931: Cell-Cell communication R-HSA-109582: Hemostasis R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-6798695: Neutrophil degranulation R-HSA-391160: Signal regulatory protein (SIRP) family interactions |
Summary | |
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Symbol | SIRPA |
Name | signal-regulatory protein alpha |
Aliases | SHPS1; SIRP; MYD-1; BIT; SHPS-1; SIRPalpha; CD172a; SIRPalpha2; MFR; SIRP-ALPHA-1; PTPNS1; protein tyrosine ...... |
Chromosomal Location | 20p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between SIRPA and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between SIRPA and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | SIRPA |
Name | signal-regulatory protein alpha |
Aliases | SHPS1; SIRP; MYD-1; BIT; SHPS-1; SIRPalpha; CD172a; SIRPalpha2; MFR; SIRP-ALPHA-1; PTPNS1; protein tyrosine ...... |
Chromosomal Location | 20p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of SIRPA in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | SIRPA |
Name | signal-regulatory protein alpha |
Aliases | SHPS1; SIRP; MYD-1; BIT; SHPS-1; SIRPalpha; CD172a; SIRPalpha2; MFR; SIRP-ALPHA-1; PTPNS1; protein tyrosine ...... |
Chromosomal Location | 20p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of SIRPA in various data sets.
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Points in the above scatter plot represent the mutation difference of SIRPA in various data sets.
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Summary | |
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Symbol | SIRPA |
Name | signal-regulatory protein alpha |
Aliases | SHPS1; SIRP; MYD-1; BIT; SHPS-1; SIRPalpha; CD172a; SIRPalpha2; MFR; SIRP-ALPHA-1; PTPNS1; protein tyrosine ...... |
Chromosomal Location | 20p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SIRPA. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | SIRPA |
Name | signal-regulatory protein alpha |
Aliases | SHPS1; SIRP; MYD-1; BIT; SHPS-1; SIRPalpha; CD172a; SIRPalpha2; MFR; SIRP-ALPHA-1; PTPNS1; protein tyrosine ...... |
Chromosomal Location | 20p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SIRPA. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SIRPA. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | SIRPA |
Name | signal-regulatory protein alpha |
Aliases | SHPS1; SIRP; MYD-1; BIT; SHPS-1; SIRPalpha; CD172a; SIRPalpha2; MFR; SIRP-ALPHA-1; PTPNS1; protein tyrosine ...... |
Chromosomal Location | 20p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SIRPA. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | SIRPA |
Name | signal-regulatory protein alpha |
Aliases | SHPS1; SIRP; MYD-1; BIT; SHPS-1; SIRPalpha; CD172a; SIRPalpha2; MFR; SIRP-ALPHA-1; PTPNS1; protein tyrosine ...... |
Chromosomal Location | 20p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of SIRPA expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | SIRPA |
Name | signal-regulatory protein alpha |
Aliases | SHPS1; SIRP; MYD-1; BIT; SHPS-1; SIRPalpha; CD172a; SIRPalpha2; MFR; SIRP-ALPHA-1; PTPNS1; protein tyrosine ...... |
Chromosomal Location | 20p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between SIRPA and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | SIRPA |
Name | signal-regulatory protein alpha |
Aliases | SHPS1; SIRP; MYD-1; BIT; SHPS-1; SIRPalpha; CD172a; SIRPalpha2; MFR; SIRP-ALPHA-1; PTPNS1; protein tyrosine ...... |
Chromosomal Location | 20p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting SIRPA collected from DrugBank database. |
There is no record. |