Summary | |
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Symbol | SLC12A7 |
Name | solute carrier family 12 (potassium/chloride transporter), member 7 |
Aliases | KCC4; DKFZP434F076; K-Cl cotransporter 4; electroneutral potassium-chloride cotransporter 4; potassium/chlor ...... |
Chromosomal Location | 5p15 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane; Multi-pass membrane protein. |
Domain |
PF00324 Amino acid permease PF03522 Solute carrier family 12 |
Function |
Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May mediate K(+) uptake into Deiters' cells in the cochlea and contribute to K(+) recycling in the inner ear. Important for the survival of cochlear outer and inner hair cells and the maintenance of the organ of Corti. May be required for basolateral Cl(-) extrusion in the kidney and contribute to renal acidification (By similarity). |
Biological Process |
GO:0006813 potassium ion transport GO:0006820 anion transport GO:0006821 chloride transport GO:0006884 cell volume homeostasis GO:0008361 regulation of cell size GO:0015672 monovalent inorganic cation transport GO:0015698 inorganic anion transport GO:0032535 regulation of cellular component size GO:0071804 cellular potassium ion transport GO:0071805 potassium ion transmembrane transport GO:0090066 regulation of anatomical structure size GO:0098656 anion transmembrane transport GO:0098661 inorganic anion transmembrane transport GO:1902476 chloride transmembrane transport |
Molecular Function |
GO:0008509 anion transmembrane transporter activity GO:0015077 monovalent inorganic cation transmembrane transporter activity GO:0015079 potassium ion transmembrane transporter activity GO:0015103 inorganic anion transmembrane transporter activity GO:0015108 chloride transmembrane transporter activity GO:0015291 secondary active transmembrane transporter activity GO:0015293 symporter activity GO:0015294 solute:cation symporter activity GO:0015296 anion:cation symporter activity GO:0015377 cation:chloride symporter activity GO:0015379 potassium:chloride symporter activity GO:0022804 active transmembrane transporter activity GO:0022820 potassium ion symporter activity GO:0022853 active ion transmembrane transporter activity GO:0046873 metal ion transmembrane transporter activity |
Cellular Component | - |
KEGG |
hsa04966 Collecting duct acid secretion |
Reactome |
R-HSA-426117: Cation-coupled Chloride cotransporters R-HSA-425407: SLC-mediated transmembrane transport R-HSA-382551: Transmembrane transport of small molecules R-HSA-425393: Transport of inorganic cations/anions and amino acids/oligopeptides |
Summary | |
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Symbol | SLC12A7 |
Name | solute carrier family 12 (potassium/chloride transporter), member 7 |
Aliases | KCC4; DKFZP434F076; K-Cl cotransporter 4; electroneutral potassium-chloride cotransporter 4; potassium/chlor ...... |
Chromosomal Location | 5p15 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between SLC12A7 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | SLC12A7 |
Name | solute carrier family 12 (potassium/chloride transporter), member 7 |
Aliases | KCC4; DKFZP434F076; K-Cl cotransporter 4; electroneutral potassium-chloride cotransporter 4; potassium/chlor ...... |
Chromosomal Location | 5p15 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of SLC12A7 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | SLC12A7 |
Name | solute carrier family 12 (potassium/chloride transporter), member 7 |
Aliases | KCC4; DKFZP434F076; K-Cl cotransporter 4; electroneutral potassium-chloride cotransporter 4; potassium/chlor ...... |
Chromosomal Location | 5p15 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of SLC12A7 in various data sets.
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Points in the above scatter plot represent the mutation difference of SLC12A7 in various data sets.
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Summary | |
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Symbol | SLC12A7 |
Name | solute carrier family 12 (potassium/chloride transporter), member 7 |
Aliases | KCC4; DKFZP434F076; K-Cl cotransporter 4; electroneutral potassium-chloride cotransporter 4; potassium/chlor ...... |
Chromosomal Location | 5p15 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SLC12A7. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | SLC12A7 |
Name | solute carrier family 12 (potassium/chloride transporter), member 7 |
Aliases | KCC4; DKFZP434F076; K-Cl cotransporter 4; electroneutral potassium-chloride cotransporter 4; potassium/chlor ...... |
Chromosomal Location | 5p15 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SLC12A7. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SLC12A7. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | SLC12A7 |
Name | solute carrier family 12 (potassium/chloride transporter), member 7 |
Aliases | KCC4; DKFZP434F076; K-Cl cotransporter 4; electroneutral potassium-chloride cotransporter 4; potassium/chlor ...... |
Chromosomal Location | 5p15 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SLC12A7. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | SLC12A7 |
Name | solute carrier family 12 (potassium/chloride transporter), member 7 |
Aliases | KCC4; DKFZP434F076; K-Cl cotransporter 4; electroneutral potassium-chloride cotransporter 4; potassium/chlor ...... |
Chromosomal Location | 5p15 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of SLC12A7 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | SLC12A7 |
Name | solute carrier family 12 (potassium/chloride transporter), member 7 |
Aliases | KCC4; DKFZP434F076; K-Cl cotransporter 4; electroneutral potassium-chloride cotransporter 4; potassium/chlor ...... |
Chromosomal Location | 5p15 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between SLC12A7 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | SLC12A7 |
Name | solute carrier family 12 (potassium/chloride transporter), member 7 |
Aliases | KCC4; DKFZP434F076; K-Cl cotransporter 4; electroneutral potassium-chloride cotransporter 4; potassium/chlor ...... |
Chromosomal Location | 5p15 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting SLC12A7 collected from DrugBank database. |
Details on drugs targeting SLC12A7.
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