Summary | |
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Symbol | SLC15A4 |
Name | solute carrier family 15 (oligopeptide transporter), member 4 |
Aliases | PHT1; PTR4; solute carrier family 15, member 4; FP12591; hPHT1; peptide transporter 4; peptide-histidine tra ...... |
Chromosomal Location | 12q24.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Membrane Multi-pass membrane protein |
Domain |
PF00854 POT family |
Function |
Proton oligopeptide cotransporter. Transports free histidine and certain di- and tripeptides. |
Biological Process |
GO:0006818 hydrogen transport GO:0006857 oligopeptide transport GO:0015672 monovalent inorganic cation transport GO:0015833 peptide transport GO:0015992 proton transport GO:0042886 amide transport |
Molecular Function |
GO:0015197 peptide transporter activity GO:0015291 secondary active transmembrane transporter activity GO:0015293 symporter activity GO:0015294 solute:cation symporter activity GO:0015295 solute:proton symporter activity GO:0015333 peptide:proton symporter activity GO:0022804 active transmembrane transporter activity GO:0022897 proton-dependent peptide secondary active transmembrane transporter activity GO:0042887 amide transmembrane transporter activity GO:1904680 peptide transmembrane transporter activity |
Cellular Component |
GO:0005765 lysosomal membrane GO:0098852 lytic vacuole membrane |
KEGG | - |
Reactome |
R-HSA-425374: Amino acid and oligopeptide SLC transporters R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-6798695: Neutrophil degranulation R-HSA-427975: Proton/oligopeptide cotransporters R-HSA-425407: SLC-mediated transmembrane transport R-HSA-382551: Transmembrane transport of small molecules R-HSA-425393: Transport of inorganic cations/anions and amino acids/oligopeptides |
Summary | |
---|---|
Symbol | SLC15A4 |
Name | solute carrier family 15 (oligopeptide transporter), member 4 |
Aliases | PHT1; PTR4; solute carrier family 15, member 4; FP12591; hPHT1; peptide transporter 4; peptide-histidine tra ...... |
Chromosomal Location | 12q24.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between SLC15A4 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | SLC15A4 |
Name | solute carrier family 15 (oligopeptide transporter), member 4 |
Aliases | PHT1; PTR4; solute carrier family 15, member 4; FP12591; hPHT1; peptide transporter 4; peptide-histidine tra ...... |
Chromosomal Location | 12q24.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of SLC15A4 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | SLC15A4 |
Name | solute carrier family 15 (oligopeptide transporter), member 4 |
Aliases | PHT1; PTR4; solute carrier family 15, member 4; FP12591; hPHT1; peptide transporter 4; peptide-histidine tra ...... |
Chromosomal Location | 12q24.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of SLC15A4 in various data sets.
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Points in the above scatter plot represent the mutation difference of SLC15A4 in various data sets.
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Summary | |
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Symbol | SLC15A4 |
Name | solute carrier family 15 (oligopeptide transporter), member 4 |
Aliases | PHT1; PTR4; solute carrier family 15, member 4; FP12591; hPHT1; peptide transporter 4; peptide-histidine tra ...... |
Chromosomal Location | 12q24.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SLC15A4. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | SLC15A4 |
Name | solute carrier family 15 (oligopeptide transporter), member 4 |
Aliases | PHT1; PTR4; solute carrier family 15, member 4; FP12591; hPHT1; peptide transporter 4; peptide-histidine tra ...... |
Chromosomal Location | 12q24.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SLC15A4. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SLC15A4. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | SLC15A4 |
Name | solute carrier family 15 (oligopeptide transporter), member 4 |
Aliases | PHT1; PTR4; solute carrier family 15, member 4; FP12591; hPHT1; peptide transporter 4; peptide-histidine tra ...... |
Chromosomal Location | 12q24.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SLC15A4. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | SLC15A4 |
Name | solute carrier family 15 (oligopeptide transporter), member 4 |
Aliases | PHT1; PTR4; solute carrier family 15, member 4; FP12591; hPHT1; peptide transporter 4; peptide-histidine tra ...... |
Chromosomal Location | 12q24.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of SLC15A4 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | SLC15A4 |
Name | solute carrier family 15 (oligopeptide transporter), member 4 |
Aliases | PHT1; PTR4; solute carrier family 15, member 4; FP12591; hPHT1; peptide transporter 4; peptide-histidine tra ...... |
Chromosomal Location | 12q24.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between SLC15A4 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | SLC15A4 |
Name | solute carrier family 15 (oligopeptide transporter), member 4 |
Aliases | PHT1; PTR4; solute carrier family 15, member 4; FP12591; hPHT1; peptide transporter 4; peptide-histidine tra ...... |
Chromosomal Location | 12q24.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting SLC15A4 collected from DrugBank database. |
There is no record. |