Summary | |
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Symbol | SLC16A10 |
Name | solute carrier family 16 (aromatic amino acid transporter), member 10 |
Aliases | MCT10; solute carrier family 16 (monocarboxylic acid transporters), member 10; PRO0813; MCT 10; T-type amino ...... |
Chromosomal Location | 6q21-q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane Multi-pass membrane protein Basolateral cell membrane |
Domain |
PF07690 Major Facilitator Superfamily |
Function |
Sodium-independent transporter that mediates the uptake of aromatic acids. Can function as a net efflux pathway for aromatic amino acids in the basosolateral epithelial cells (By similarity). |
Biological Process |
GO:0003333 amino acid transmembrane transport GO:0006865 amino acid transport GO:0009914 hormone transport GO:0010817 regulation of hormone levels GO:0015801 aromatic amino acid transport GO:0015849 organic acid transport GO:0070327 thyroid hormone transport GO:0072337 modified amino acid transport GO:1903825 organic acid transmembrane transport GO:1905039 carboxylic acid transmembrane transport |
Molecular Function |
GO:0005342 organic acid transmembrane transporter activity GO:0015171 amino acid transmembrane transporter activity GO:0015173 aromatic amino acid transmembrane transporter activity GO:0015291 secondary active transmembrane transporter activity GO:0015349 thyroid hormone transmembrane transporter activity GO:0022804 active transmembrane transporter activity GO:0046943 carboxylic acid transmembrane transporter activity GO:0072349 modified amino acid transmembrane transporter activity |
Cellular Component |
GO:0016323 basolateral plasma membrane |
KEGG |
hsa04919 Thyroid hormone signaling pathway hsa04974 Protein digestion and absorption |
Reactome |
R-HSA-425374: Amino acid and oligopeptide SLC transporters R-HSA-352230: Amino acid transport across the plasma membrane R-HSA-425407: SLC-mediated transmembrane transport R-HSA-382551: Transmembrane transport of small molecules R-HSA-425393: Transport of inorganic cations/anions and amino acids/oligopeptides |
Summary | |
---|---|
Symbol | SLC16A10 |
Name | solute carrier family 16 (aromatic amino acid transporter), member 10 |
Aliases | MCT10; solute carrier family 16 (monocarboxylic acid transporters), member 10; PRO0813; MCT 10; T-type amino ...... |
Chromosomal Location | 6q21-q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between SLC16A10 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | SLC16A10 |
Name | solute carrier family 16 (aromatic amino acid transporter), member 10 |
Aliases | MCT10; solute carrier family 16 (monocarboxylic acid transporters), member 10; PRO0813; MCT 10; T-type amino ...... |
Chromosomal Location | 6q21-q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of SLC16A10 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | SLC16A10 |
Name | solute carrier family 16 (aromatic amino acid transporter), member 10 |
Aliases | MCT10; solute carrier family 16 (monocarboxylic acid transporters), member 10; PRO0813; MCT 10; T-type amino ...... |
Chromosomal Location | 6q21-q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of SLC16A10 in various data sets.
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Points in the above scatter plot represent the mutation difference of SLC16A10 in various data sets.
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Summary | |
---|---|
Symbol | SLC16A10 |
Name | solute carrier family 16 (aromatic amino acid transporter), member 10 |
Aliases | MCT10; solute carrier family 16 (monocarboxylic acid transporters), member 10; PRO0813; MCT 10; T-type amino ...... |
Chromosomal Location | 6q21-q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SLC16A10. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | SLC16A10 |
Name | solute carrier family 16 (aromatic amino acid transporter), member 10 |
Aliases | MCT10; solute carrier family 16 (monocarboxylic acid transporters), member 10; PRO0813; MCT 10; T-type amino ...... |
Chromosomal Location | 6q21-q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SLC16A10. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SLC16A10. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | SLC16A10 |
Name | solute carrier family 16 (aromatic amino acid transporter), member 10 |
Aliases | MCT10; solute carrier family 16 (monocarboxylic acid transporters), member 10; PRO0813; MCT 10; T-type amino ...... |
Chromosomal Location | 6q21-q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SLC16A10. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | SLC16A10 |
Name | solute carrier family 16 (aromatic amino acid transporter), member 10 |
Aliases | MCT10; solute carrier family 16 (monocarboxylic acid transporters), member 10; PRO0813; MCT 10; T-type amino ...... |
Chromosomal Location | 6q21-q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of SLC16A10 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | SLC16A10 |
Name | solute carrier family 16 (aromatic amino acid transporter), member 10 |
Aliases | MCT10; solute carrier family 16 (monocarboxylic acid transporters), member 10; PRO0813; MCT 10; T-type amino ...... |
Chromosomal Location | 6q21-q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between SLC16A10 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | SLC16A10 |
Name | solute carrier family 16 (aromatic amino acid transporter), member 10 |
Aliases | MCT10; solute carrier family 16 (monocarboxylic acid transporters), member 10; PRO0813; MCT 10; T-type amino ...... |
Chromosomal Location | 6q21-q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting SLC16A10 collected from DrugBank database. |
There is no record. |