Summary | |
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Symbol | SLC16A12 |
Name | solute carrier family 16, member 12 |
Aliases | MCT12; monocarboxylic acid transporter 12; solute carrier family 16 (monocarboxylic acid transporters), memb ...... |
Chromosomal Location | 10q23.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane Multi-pass membrane protein |
Domain |
PF07690 Major Facilitator Superfamily |
Function |
Proton-linked monocarboxylate transporter that mediates creatine transport across the plasma membrane. |
Biological Process |
GO:0006820 anion transport GO:0015711 organic anion transport GO:0015718 monocarboxylic acid transport GO:0015727 lactate transport GO:0015881 creatine transport GO:0035873 lactate transmembrane transport GO:0035879 plasma membrane lactate transport GO:0046942 carboxylic acid transport GO:0072337 modified amino acid transport GO:0098656 anion transmembrane transport GO:1902598 creatine transmembrane transport |
Molecular Function |
GO:0005308 creatine transmembrane transporter activity GO:0008509 anion transmembrane transporter activity GO:0008514 organic anion transmembrane transporter activity GO:0015129 lactate transmembrane transporter activity GO:0015291 secondary active transmembrane transporter activity GO:0015293 symporter activity GO:0022804 active transmembrane transporter activity GO:0051184 cofactor transporter activity GO:0072349 modified amino acid transmembrane transporter activity |
Cellular Component | - |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | SLC16A12 |
Name | solute carrier family 16, member 12 |
Aliases | MCT12; monocarboxylic acid transporter 12; solute carrier family 16 (monocarboxylic acid transporters), memb ...... |
Chromosomal Location | 10q23.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between SLC16A12 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | SLC16A12 |
Name | solute carrier family 16, member 12 |
Aliases | MCT12; monocarboxylic acid transporter 12; solute carrier family 16 (monocarboxylic acid transporters), memb ...... |
Chromosomal Location | 10q23.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of SLC16A12 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | SLC16A12 |
Name | solute carrier family 16, member 12 |
Aliases | MCT12; monocarboxylic acid transporter 12; solute carrier family 16 (monocarboxylic acid transporters), memb ...... |
Chromosomal Location | 10q23.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of SLC16A12 in various data sets.
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Points in the above scatter plot represent the mutation difference of SLC16A12 in various data sets.
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Summary | |
---|---|
Symbol | SLC16A12 |
Name | solute carrier family 16, member 12 |
Aliases | MCT12; monocarboxylic acid transporter 12; solute carrier family 16 (monocarboxylic acid transporters), memb ...... |
Chromosomal Location | 10q23.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SLC16A12. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | SLC16A12 |
Name | solute carrier family 16, member 12 |
Aliases | MCT12; monocarboxylic acid transporter 12; solute carrier family 16 (monocarboxylic acid transporters), memb ...... |
Chromosomal Location | 10q23.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SLC16A12. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SLC16A12. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | SLC16A12 |
Name | solute carrier family 16, member 12 |
Aliases | MCT12; monocarboxylic acid transporter 12; solute carrier family 16 (monocarboxylic acid transporters), memb ...... |
Chromosomal Location | 10q23.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SLC16A12. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | SLC16A12 |
Name | solute carrier family 16, member 12 |
Aliases | MCT12; monocarboxylic acid transporter 12; solute carrier family 16 (monocarboxylic acid transporters), memb ...... |
Chromosomal Location | 10q23.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of SLC16A12 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | SLC16A12 |
Name | solute carrier family 16, member 12 |
Aliases | MCT12; monocarboxylic acid transporter 12; solute carrier family 16 (monocarboxylic acid transporters), memb ...... |
Chromosomal Location | 10q23.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between SLC16A12 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | SLC16A12 |
Name | solute carrier family 16, member 12 |
Aliases | MCT12; monocarboxylic acid transporter 12; solute carrier family 16 (monocarboxylic acid transporters), memb ...... |
Chromosomal Location | 10q23.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting SLC16A12 collected from DrugBank database. |
There is no record. |