Summary | |
---|---|
Symbol | SLC16A3 |
Name | solute carrier family 16 (monocarboxylate transporter), member 3 |
Aliases | solute carrier family 16 (monocarboxylic acid transporters), member 3; solute carrier family 16, member 3 (m ...... |
Chromosomal Location | 17q25.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane; Multi-pass membrane protein. |
Domain |
PF07690 Major Facilitator Superfamily |
Function |
Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity). |
Biological Process |
GO:0006090 pyruvate metabolic process GO:0006820 anion transport GO:0015711 organic anion transport GO:0015718 monocarboxylic acid transport GO:0015727 lactate transport GO:0035873 lactate transmembrane transport GO:0035879 plasma membrane lactate transport GO:0046942 carboxylic acid transport GO:0050900 leukocyte migration GO:0098656 anion transmembrane transport |
Molecular Function |
GO:0005342 organic acid transmembrane transporter activity GO:0008028 monocarboxylic acid transmembrane transporter activity GO:0008509 anion transmembrane transporter activity GO:0008514 organic anion transmembrane transporter activity GO:0015129 lactate transmembrane transporter activity GO:0015291 secondary active transmembrane transporter activity GO:0015293 symporter activity GO:0022804 active transmembrane transporter activity GO:0046943 carboxylic acid transmembrane transporter activity |
Cellular Component |
GO:0005635 nuclear envelope GO:0015629 actin cytoskeleton GO:0031965 nuclear membrane |
KEGG | - |
Reactome |
R-HSA-210991: Basigin interactions R-HSA-425471: Bile salt and organic anion SLC transporters R-HSA-202733: Cell surface interactions at the vascular wall R-HSA-109582: Hemostasis R-HSA-1430728: Metabolism R-HSA-433692: Proton-coupled monocarboxylate transport R-HSA-70268: Pyruvate metabolism R-HSA-71406: Pyruvate metabolism and Citric Acid (TCA) cycle R-HSA-425407: SLC-mediated transmembrane transport R-HSA-1428517: The citric acid (TCA) cycle and respiratory electron transport R-HSA-382551: Transmembrane transport of small molecules R-HSA-425366: Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds |
Summary | |
---|---|
Symbol | SLC16A3 |
Name | solute carrier family 16 (monocarboxylate transporter), member 3 |
Aliases | solute carrier family 16 (monocarboxylic acid transporters), member 3; solute carrier family 16, member 3 (m ...... |
Chromosomal Location | 17q25.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between SLC16A3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | SLC16A3 |
Name | solute carrier family 16 (monocarboxylate transporter), member 3 |
Aliases | solute carrier family 16 (monocarboxylic acid transporters), member 3; solute carrier family 16, member 3 (m ...... |
Chromosomal Location | 17q25.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
[ TOP ]
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Statistical results of SLC16A3 in screening data sets for detecting immune reponses.
|
Summary | |
---|---|
Symbol | SLC16A3 |
Name | solute carrier family 16 (monocarboxylate transporter), member 3 |
Aliases | solute carrier family 16 (monocarboxylic acid transporters), member 3; solute carrier family 16, member 3 (m ...... |
Chromosomal Location | 17q25.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of SLC16A3 in various data sets.
|
Points in the above scatter plot represent the mutation difference of SLC16A3 in various data sets.
|
Summary | |
---|---|
Symbol | SLC16A3 |
Name | solute carrier family 16 (monocarboxylate transporter), member 3 |
Aliases | solute carrier family 16 (monocarboxylic acid transporters), member 3; solute carrier family 16, member 3 (m ...... |
Chromosomal Location | 17q25.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SLC16A3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | SLC16A3 |
Name | solute carrier family 16 (monocarboxylate transporter), member 3 |
Aliases | solute carrier family 16 (monocarboxylic acid transporters), member 3; solute carrier family 16, member 3 (m ...... |
Chromosomal Location | 17q25.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SLC16A3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SLC16A3. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | SLC16A3 |
Name | solute carrier family 16 (monocarboxylate transporter), member 3 |
Aliases | solute carrier family 16 (monocarboxylic acid transporters), member 3; solute carrier family 16, member 3 (m ...... |
Chromosomal Location | 17q25.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SLC16A3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | SLC16A3 |
Name | solute carrier family 16 (monocarboxylate transporter), member 3 |
Aliases | solute carrier family 16 (monocarboxylic acid transporters), member 3; solute carrier family 16, member 3 (m ...... |
Chromosomal Location | 17q25.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of SLC16A3 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | SLC16A3 |
Name | solute carrier family 16 (monocarboxylate transporter), member 3 |
Aliases | solute carrier family 16 (monocarboxylic acid transporters), member 3; solute carrier family 16, member 3 (m ...... |
Chromosomal Location | 17q25.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between SLC16A3 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | SLC16A3 |
Name | solute carrier family 16 (monocarboxylate transporter), member 3 |
Aliases | solute carrier family 16 (monocarboxylic acid transporters), member 3; solute carrier family 16, member 3 (m ...... |
Chromosomal Location | 17q25.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting SLC16A3 collected from DrugBank database. |
Details on drugs targeting SLC16A3.
|