Summary | |
---|---|
Symbol | SLC17A3 |
Name | solute carrier family 17 (organic anion transporter), member 3 |
Aliases | NPT4; solute carrier family 17 (sodium phosphate), member 3; Na(+)/PI cotransporter 4; sodium/phosphate cotr ...... |
Chromosomal Location | 6p22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Isoform 1: Endoplasmic reticulum membrane Multi-pass membrane protein ; SUBCELLULAR LOCATION: Isoform 2: Cell membrane Multi-pass membrane protein |
Domain |
PF07690 Major Facilitator Superfamily |
Function |
Isoform 2: voltage-driven, multispecific, organic anion transporter able to transport para-aminohippurate (PAH), estrone sulfate, estradiol-17-beta-glucuronide, bumetanide, and ochratoxin A. Isoform 2 functions as urate efflux transporter on the apical side of renal proximal tubule and is likely to act as an exit path for organic anionic drugs as well as urate in vivo. May be involved in actively transporting phosphate into cells via Na(+) cotransport. |
Biological Process |
GO:0006814 sodium ion transport GO:0006817 phosphate ion transport GO:0006820 anion transport GO:0006855 drug transmembrane transport GO:0015672 monovalent inorganic cation transport GO:0015698 inorganic anion transport GO:0015711 organic anion transport GO:0015712 hexose phosphate transport GO:0015747 urate transport GO:0015748 organophosphate ester transport GO:0015760 glucose-6-phosphate transport GO:0015849 organic acid transport GO:0015893 drug transport GO:0034762 regulation of transmembrane transport GO:0034765 regulation of ion transmembrane transport GO:0035435 phosphate ion transmembrane transport GO:0035725 sodium ion transmembrane transport GO:0042493 response to drug GO:0044070 regulation of anion transport GO:0044341 sodium-dependent phosphate transport GO:0046415 urate metabolic process GO:0098656 anion transmembrane transport GO:0098661 inorganic anion transmembrane transport GO:1901264 carbohydrate derivative transport GO:1901998 toxin transport GO:1903825 organic acid transmembrane transport GO:1903959 regulation of anion transmembrane transport |
Molecular Function |
GO:0005216 ion channel activity GO:0005244 voltage-gated ion channel activity GO:0005253 anion channel activity GO:0005342 organic acid transmembrane transporter activity GO:0005436 sodium:phosphate symporter activity GO:0008308 voltage-gated anion channel activity GO:0008509 anion transmembrane transporter activity GO:0008514 organic anion transmembrane transporter activity GO:0015077 monovalent inorganic cation transmembrane transporter activity GO:0015081 sodium ion transmembrane transporter activity GO:0015103 inorganic anion transmembrane transporter activity GO:0015114 phosphate ion transmembrane transporter activity GO:0015143 urate transmembrane transporter activity GO:0015238 drug transmembrane transporter activity GO:0015267 channel activity GO:0015291 secondary active transmembrane transporter activity GO:0015293 symporter activity GO:0015294 solute:cation symporter activity GO:0015296 anion:cation symporter activity GO:0015321 sodium-dependent phosphate transmembrane transporter activity GO:0015562 efflux transmembrane transporter activity GO:0019534 toxin transporter activity GO:0022803 passive transmembrane transporter activity GO:0022804 active transmembrane transporter activity GO:0022832 voltage-gated channel activity GO:0022836 gated channel activity GO:0022838 substrate-specific channel activity GO:0022853 active ion transmembrane transporter activity GO:0046873 metal ion transmembrane transporter activity GO:0090484 drug transporter activity GO:1901702 salt transmembrane transporter activity |
Cellular Component |
GO:0005903 brush border GO:0016324 apical plasma membrane GO:0031253 cell projection membrane GO:0031526 brush border membrane GO:0045177 apical part of cell GO:0098862 cluster of actin-based cell projections |
KEGG | - |
Reactome |
R-HSA-983712: Ion channel transport R-HSA-2672351: Stimuli-sensing channels R-HSA-382551: Transmembrane transport of small molecules |
Summary | |
---|---|
Symbol | SLC17A3 |
Name | solute carrier family 17 (organic anion transporter), member 3 |
Aliases | NPT4; solute carrier family 17 (sodium phosphate), member 3; Na(+)/PI cotransporter 4; sodium/phosphate cotr ...... |
Chromosomal Location | 6p22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between SLC17A3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | SLC17A3 |
Name | solute carrier family 17 (organic anion transporter), member 3 |
Aliases | NPT4; solute carrier family 17 (sodium phosphate), member 3; Na(+)/PI cotransporter 4; sodium/phosphate cotr ...... |
Chromosomal Location | 6p22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
[ TOP ]
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Statistical results of SLC17A3 in screening data sets for detecting immune reponses.
|
Summary | |
---|---|
Symbol | SLC17A3 |
Name | solute carrier family 17 (organic anion transporter), member 3 |
Aliases | NPT4; solute carrier family 17 (sodium phosphate), member 3; Na(+)/PI cotransporter 4; sodium/phosphate cotr ...... |
Chromosomal Location | 6p22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of SLC17A3 in various data sets.
|
Points in the above scatter plot represent the mutation difference of SLC17A3 in various data sets.
|
Summary | |
---|---|
Symbol | SLC17A3 |
Name | solute carrier family 17 (organic anion transporter), member 3 |
Aliases | NPT4; solute carrier family 17 (sodium phosphate), member 3; Na(+)/PI cotransporter 4; sodium/phosphate cotr ...... |
Chromosomal Location | 6p22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SLC17A3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | SLC17A3 |
Name | solute carrier family 17 (organic anion transporter), member 3 |
Aliases | NPT4; solute carrier family 17 (sodium phosphate), member 3; Na(+)/PI cotransporter 4; sodium/phosphate cotr ...... |
Chromosomal Location | 6p22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SLC17A3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SLC17A3. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | SLC17A3 |
Name | solute carrier family 17 (organic anion transporter), member 3 |
Aliases | NPT4; solute carrier family 17 (sodium phosphate), member 3; Na(+)/PI cotransporter 4; sodium/phosphate cotr ...... |
Chromosomal Location | 6p22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SLC17A3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | SLC17A3 |
Name | solute carrier family 17 (organic anion transporter), member 3 |
Aliases | NPT4; solute carrier family 17 (sodium phosphate), member 3; Na(+)/PI cotransporter 4; sodium/phosphate cotr ...... |
Chromosomal Location | 6p22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of SLC17A3 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | SLC17A3 |
Name | solute carrier family 17 (organic anion transporter), member 3 |
Aliases | NPT4; solute carrier family 17 (sodium phosphate), member 3; Na(+)/PI cotransporter 4; sodium/phosphate cotr ...... |
Chromosomal Location | 6p22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between SLC17A3 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | SLC17A3 |
Name | solute carrier family 17 (organic anion transporter), member 3 |
Aliases | NPT4; solute carrier family 17 (sodium phosphate), member 3; Na(+)/PI cotransporter 4; sodium/phosphate cotr ...... |
Chromosomal Location | 6p22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting SLC17A3 collected from DrugBank database. |
There is no record. |