Summary | |
---|---|
Symbol | SLC1A7 |
Name | solute carrier family 1 (glutamate transporter), member 7 |
Aliases | EAAT5; excitatory amino acid transporter 5 (retinal glutamate transporter); retinal glutamate transporter; S ...... |
Chromosomal Location | 1p32.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Membrane; Multi-pass membrane protein. |
Domain |
PF00375 Sodium |
Function |
Transports L-glutamate; the L-glutamate uptake is sodium- and voltage-dependent and chloride-independent. Its associated chloride conductance may participate in visual processing. |
Biological Process |
GO:0003333 amino acid transmembrane transport GO:0006820 anion transport GO:0006835 dicarboxylic acid transport GO:0006865 amino acid transport GO:0014047 glutamate secretion GO:0015711 organic anion transport GO:0015800 acidic amino acid transport GO:0015807 L-amino acid transport GO:0015813 L-glutamate transport GO:0015849 organic acid transport GO:0046942 carboxylic acid transport GO:0089711 L-glutamate transmembrane transport GO:0098656 anion transmembrane transport GO:1903825 organic acid transmembrane transport GO:1905039 carboxylic acid transmembrane transport |
Molecular Function |
GO:0005313 L-glutamate transmembrane transporter activity GO:0005314 high-affinity glutamate transmembrane transporter activity GO:0005342 organic acid transmembrane transporter activity GO:0008509 anion transmembrane transporter activity GO:0008514 organic anion transmembrane transporter activity GO:0015077 monovalent inorganic cation transmembrane transporter activity GO:0015081 sodium ion transmembrane transporter activity GO:0015171 amino acid transmembrane transporter activity GO:0015172 acidic amino acid transmembrane transporter activity GO:0015291 secondary active transmembrane transporter activity GO:0015293 symporter activity GO:0015294 solute:cation symporter activity GO:0015370 solute:sodium symporter activity GO:0022804 active transmembrane transporter activity GO:0046873 metal ion transmembrane transporter activity GO:0046943 carboxylic acid transmembrane transporter activity |
Cellular Component | - |
KEGG |
hsa04724 Glutamatergic synapse |
Reactome |
R-HSA-425374: Amino acid and oligopeptide SLC transporters R-HSA-210500: Glutamate Neurotransmitter Release Cycle R-HSA-112316: Neuronal System R-HSA-112310: Neurotransmitter Release Cycle R-HSA-425407: SLC-mediated transmembrane transport R-HSA-382551: Transmembrane transport of small molecules R-HSA-112315: Transmission across Chemical Synapses R-HSA-425393: Transport of inorganic cations/anions and amino acids/oligopeptides |
Summary | |
---|---|
Symbol | SLC1A7 |
Name | solute carrier family 1 (glutamate transporter), member 7 |
Aliases | EAAT5; excitatory amino acid transporter 5 (retinal glutamate transporter); retinal glutamate transporter; S ...... |
Chromosomal Location | 1p32.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between SLC1A7 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | SLC1A7 |
Name | solute carrier family 1 (glutamate transporter), member 7 |
Aliases | EAAT5; excitatory amino acid transporter 5 (retinal glutamate transporter); retinal glutamate transporter; S ...... |
Chromosomal Location | 1p32.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
[ TOP ]
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Statistical results of SLC1A7 in screening data sets for detecting immune reponses.
|
Summary | |
---|---|
Symbol | SLC1A7 |
Name | solute carrier family 1 (glutamate transporter), member 7 |
Aliases | EAAT5; excitatory amino acid transporter 5 (retinal glutamate transporter); retinal glutamate transporter; S ...... |
Chromosomal Location | 1p32.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of SLC1A7 in various data sets.
|
Points in the above scatter plot represent the mutation difference of SLC1A7 in various data sets.
|
Summary | |
---|---|
Symbol | SLC1A7 |
Name | solute carrier family 1 (glutamate transporter), member 7 |
Aliases | EAAT5; excitatory amino acid transporter 5 (retinal glutamate transporter); retinal glutamate transporter; S ...... |
Chromosomal Location | 1p32.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SLC1A7. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | SLC1A7 |
Name | solute carrier family 1 (glutamate transporter), member 7 |
Aliases | EAAT5; excitatory amino acid transporter 5 (retinal glutamate transporter); retinal glutamate transporter; S ...... |
Chromosomal Location | 1p32.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SLC1A7. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SLC1A7. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | SLC1A7 |
Name | solute carrier family 1 (glutamate transporter), member 7 |
Aliases | EAAT5; excitatory amino acid transporter 5 (retinal glutamate transporter); retinal glutamate transporter; S ...... |
Chromosomal Location | 1p32.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SLC1A7. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | SLC1A7 |
Name | solute carrier family 1 (glutamate transporter), member 7 |
Aliases | EAAT5; excitatory amino acid transporter 5 (retinal glutamate transporter); retinal glutamate transporter; S ...... |
Chromosomal Location | 1p32.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of SLC1A7 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | SLC1A7 |
Name | solute carrier family 1 (glutamate transporter), member 7 |
Aliases | EAAT5; excitatory amino acid transporter 5 (retinal glutamate transporter); retinal glutamate transporter; S ...... |
Chromosomal Location | 1p32.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between SLC1A7 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | SLC1A7 |
Name | solute carrier family 1 (glutamate transporter), member 7 |
Aliases | EAAT5; excitatory amino acid transporter 5 (retinal glutamate transporter); retinal glutamate transporter; S ...... |
Chromosomal Location | 1p32.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting SLC1A7 collected from DrugBank database. |
Details on drugs targeting SLC1A7.
|