Browse SLC22A5

Summary
SymbolSLC22A5
Namesolute carrier family 22 (organic cation/carnitine transporter), member 5
Aliases OCTN2; CDSP; high-affinity sodium dependent carnitine cotransporter; organic cation/carnitine transporter 2; ......
Chromosomal Location5q23.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Membrane Multi-pass membrane protein
Domain PF00083 Sugar (and other) transporter
Function

Sodium-ion dependent, high affinity carnitine transporter. Involved in the active cellular uptake of carnitine. Transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Also relative uptake activity ratio of carnitine to TEA is 11.3.

> Gene Ontology
 
Biological Process GO:0001894 tissue homeostasis
GO:0006577 amino-acid betaine metabolic process
GO:0006814 sodium ion transport
GO:0006855 drug transmembrane transport
GO:0007586 digestion
GO:0009372 quorum sensing
GO:0009437 carnitine metabolic process
GO:0010669 epithelial structure maintenance
GO:0015672 monovalent inorganic cation transport
GO:0015695 organic cation transport
GO:0015697 quaternary ammonium group transport
GO:0015838 amino-acid betaine transport
GO:0015879 carnitine transport
GO:0015893 drug transport
GO:0022600 digestive system process
GO:0030277 maintenance of gastrointestinal epithelium
GO:0032844 regulation of homeostatic process
GO:0032846 positive regulation of homeostatic process
GO:0042493 response to drug
GO:0044057 regulation of system process
GO:0044058 regulation of digestive system process
GO:0048871 multicellular organismal homeostasis
GO:0048872 homeostasis of number of cells
GO:0048874 homeostasis of number of cells in a free-living population
GO:0051701 interaction with host
GO:0052097 interspecies quorum sensing
GO:0052106 quorum sensing involved in interaction with host
GO:0060249 anatomical structure homeostasis
GO:0060456 positive regulation of digestive system process
GO:0060729 intestinal epithelial structure maintenance
GO:0060730 regulation of intestinal epithelial structure maintenance
GO:0060731 positive regulation of intestinal epithelial structure maintenance
GO:0070715 sodium-dependent organic cation transport
GO:1902603 carnitine transmembrane transport
Molecular Function GO:0015101 organic cation transmembrane transporter activity
GO:0015199 amino-acid betaine transmembrane transporter activity
GO:0015226 carnitine transmembrane transporter activity
GO:0015238 drug transmembrane transporter activity
GO:0015291 secondary active transmembrane transporter activity
GO:0015293 symporter activity
GO:0015297 antiporter activity
GO:0015298 solute:cation antiporter activity
GO:0015491 cation:cation antiporter activity
GO:0015651 quaternary ammonium group transmembrane transporter activity
GO:0022804 active transmembrane transporter activity
GO:0030165 PDZ domain binding
GO:0072349 modified amino acid transmembrane transporter activity
GO:0090484 drug transporter activity
GO:0099516 ion antiporter activity
Cellular Component GO:0005903 brush border
GO:0016324 apical plasma membrane
GO:0031253 cell projection membrane
GO:0031526 brush border membrane
GO:0045177 apical part of cell
GO:0098862 cluster of actin-based cell projections
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-549127: Organic cation transport
R-HSA-549132: Organic cation/anion/zwitterion transport
R-HSA-425407: SLC-mediated transmembrane transport
R-HSA-382551: Transmembrane transport of small molecules
R-HSA-425366: Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
Summary
SymbolSLC22A5
Namesolute carrier family 22 (organic cation/carnitine transporter), member 5
Aliases OCTN2; CDSP; high-affinity sodium dependent carnitine cotransporter; organic cation/carnitine transporter 2; ......
Chromosomal Location5q23.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between SLC22A5 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolSLC22A5
Namesolute carrier family 22 (organic cation/carnitine transporter), member 5
Aliases OCTN2; CDSP; high-affinity sodium dependent carnitine cotransporter; organic cation/carnitine transporter 2; ......
Chromosomal Location5q23.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of SLC22A5 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolSLC22A5
Namesolute carrier family 22 (organic cation/carnitine transporter), member 5
Aliases OCTN2; CDSP; high-affinity sodium dependent carnitine cotransporter; organic cation/carnitine transporter 2; ......
Chromosomal Location5q23.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of SLC22A5 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.2730.254
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.0560.941
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.4270.499
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.9360.033
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.8910.597
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.9950.642
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.0290.909
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.0420.962
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.030.975
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.1860.889
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.0620.974
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.1120.315
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of SLC22A5 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 141705.9-5.91
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 41407.1-7.11
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.71.42.30.469
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.71.720.532
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.1011.10.36
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47250250.364
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolSLC22A5
Namesolute carrier family 22 (organic cation/carnitine transporter), member 5
Aliases OCTN2; CDSP; high-affinity sodium dependent carnitine cotransporter; organic cation/carnitine transporter 2; ......
Chromosomal Location5q23.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SLC22A5. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolSLC22A5
Namesolute carrier family 22 (organic cation/carnitine transporter), member 5
Aliases OCTN2; CDSP; high-affinity sodium dependent carnitine cotransporter; organic cation/carnitine transporter 2; ......
Chromosomal Location5q23.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SLC22A5. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SLC22A5.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolSLC22A5
Namesolute carrier family 22 (organic cation/carnitine transporter), member 5
Aliases OCTN2; CDSP; high-affinity sodium dependent carnitine cotransporter; organic cation/carnitine transporter 2; ......
Chromosomal Location5q23.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SLC22A5. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolSLC22A5
Namesolute carrier family 22 (organic cation/carnitine transporter), member 5
Aliases OCTN2; CDSP; high-affinity sodium dependent carnitine cotransporter; organic cation/carnitine transporter 2; ......
Chromosomal Location5q23.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of SLC22A5 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolSLC22A5
Namesolute carrier family 22 (organic cation/carnitine transporter), member 5
Aliases OCTN2; CDSP; high-affinity sodium dependent carnitine cotransporter; organic cation/carnitine transporter 2; ......
Chromosomal Location5q23.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between SLC22A5 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolSLC22A5
Namesolute carrier family 22 (organic cation/carnitine transporter), member 5
Aliases OCTN2; CDSP; high-affinity sodium dependent carnitine cotransporter; organic cation/carnitine transporter 2; ......
Chromosomal Location5q23.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting SLC22A5 collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting SLC22A5.
ID Name Drug Type Targets #Targets
DB00583L-CarnitineSmall MoleculeCES1, CPT1A, CPT2, CRAT, CROT, MPO, SLC22A4, SLC22A5, SLC25A20, SL ......11