Summary | |
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Symbol | SLC24A3 |
Name | solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 |
Aliases | NCKX3; Na(+)/K(+)/Ca(2+)-exchange protein 3; sodium calcium exchanger; solute carrier family 24 member 3; So ...... |
Chromosomal Location | 20p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Membrane; Multi-pass membrane protein. |
Domain |
PF01699 Sodium/calcium exchanger protein |
Function |
Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). |
Biological Process |
GO:0006813 potassium ion transport GO:0006814 sodium ion transport GO:0006816 calcium ion transport GO:0006874 cellular calcium ion homeostasis GO:0006875 cellular metal ion homeostasis GO:0015672 monovalent inorganic cation transport GO:0035725 sodium ion transmembrane transport GO:0055074 calcium ion homeostasis GO:0070588 calcium ion transmembrane transport GO:0070838 divalent metal ion transport GO:0072503 cellular divalent inorganic cation homeostasis GO:0072507 divalent inorganic cation homeostasis GO:0072511 divalent inorganic cation transport |
Molecular Function |
GO:0005216 ion channel activity GO:0005261 cation channel activity GO:0005262 calcium channel activity GO:0008273 calcium, potassium:sodium antiporter activity GO:0015077 monovalent inorganic cation transmembrane transporter activity GO:0015079 potassium ion transmembrane transporter activity GO:0015081 sodium ion transmembrane transporter activity GO:0015085 calcium ion transmembrane transporter activity GO:0015267 channel activity GO:0015291 secondary active transmembrane transporter activity GO:0015293 symporter activity GO:0015297 antiporter activity GO:0015298 solute:cation antiporter activity GO:0015368 calcium:cation antiporter activity GO:0015491 cation:cation antiporter activity GO:0022803 passive transmembrane transporter activity GO:0022804 active transmembrane transporter activity GO:0022821 potassium ion antiporter activity GO:0022838 substrate-specific channel activity GO:0030955 potassium ion binding GO:0031402 sodium ion binding GO:0031420 alkali metal ion binding GO:0046873 metal ion transmembrane transporter activity GO:0072509 divalent inorganic cation transmembrane transporter activity GO:0099516 ion antiporter activity |
Cellular Component | - |
KEGG | - |
Reactome |
R-HSA-425407: SLC-mediated transmembrane transport R-HSA-425561: Sodium/Calcium exchangers R-HSA-382551: Transmembrane transport of small molecules R-HSA-425393: Transport of inorganic cations/anions and amino acids/oligopeptides |
Summary | |
---|---|
Symbol | SLC24A3 |
Name | solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 |
Aliases | NCKX3; Na(+)/K(+)/Ca(2+)-exchange protein 3; sodium calcium exchanger; solute carrier family 24 member 3; So ...... |
Chromosomal Location | 20p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between SLC24A3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | SLC24A3 |
Name | solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 |
Aliases | NCKX3; Na(+)/K(+)/Ca(2+)-exchange protein 3; sodium calcium exchanger; solute carrier family 24 member 3; So ...... |
Chromosomal Location | 20p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of SLC24A3 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | SLC24A3 |
Name | solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 |
Aliases | NCKX3; Na(+)/K(+)/Ca(2+)-exchange protein 3; sodium calcium exchanger; solute carrier family 24 member 3; So ...... |
Chromosomal Location | 20p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of SLC24A3 in various data sets.
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Points in the above scatter plot represent the mutation difference of SLC24A3 in various data sets.
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Summary | |
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Symbol | SLC24A3 |
Name | solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 |
Aliases | NCKX3; Na(+)/K(+)/Ca(2+)-exchange protein 3; sodium calcium exchanger; solute carrier family 24 member 3; So ...... |
Chromosomal Location | 20p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SLC24A3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | SLC24A3 |
Name | solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 |
Aliases | NCKX3; Na(+)/K(+)/Ca(2+)-exchange protein 3; sodium calcium exchanger; solute carrier family 24 member 3; So ...... |
Chromosomal Location | 20p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SLC24A3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SLC24A3. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | SLC24A3 |
Name | solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 |
Aliases | NCKX3; Na(+)/K(+)/Ca(2+)-exchange protein 3; sodium calcium exchanger; solute carrier family 24 member 3; So ...... |
Chromosomal Location | 20p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SLC24A3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | SLC24A3 |
Name | solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 |
Aliases | NCKX3; Na(+)/K(+)/Ca(2+)-exchange protein 3; sodium calcium exchanger; solute carrier family 24 member 3; So ...... |
Chromosomal Location | 20p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of SLC24A3 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | SLC24A3 |
Name | solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 |
Aliases | NCKX3; Na(+)/K(+)/Ca(2+)-exchange protein 3; sodium calcium exchanger; solute carrier family 24 member 3; So ...... |
Chromosomal Location | 20p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between SLC24A3 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | SLC24A3 |
Name | solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 |
Aliases | NCKX3; Na(+)/K(+)/Ca(2+)-exchange protein 3; sodium calcium exchanger; solute carrier family 24 member 3; So ...... |
Chromosomal Location | 20p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting SLC24A3 collected from DrugBank database. |
There is no record. |