Summary | |
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Symbol | SLC25A29 |
Name | solute carrier family 25 (mitochondrial carnitine/acylcarnitine carrier), member 29 |
Aliases | FLJ38975; C14orf69; chromosome 14 open reading frame 69; solute carrier family 25, member 29; CACL; ORNT3; c ...... |
Chromosomal Location | 14q32.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Mitochondrion inner membrane Multi-pass membrane protein |
Domain |
PF00153 Mitochondrial carrier protein |
Function |
Transports arginine, lysine, homoarginine, methylarginine and, to a much lesser extent, ornithine and histidine (PubMed:24652292). Can restore ornithine transport in cells lacking the primary mitochondrial ornithine transporter SLC25A15 (PubMed:19287344). Does not transport carnitine nor acylcarnitines (PubMed:24652292). Functions by both counter-exchange and uniport mechanisms (PubMed:24652292). |
Biological Process |
GO:0006844 acyl carnitine transport GO:0015697 quaternary ammonium group transport GO:0051181 cofactor transport GO:1902616 acyl carnitine transmembrane transport |
Molecular Function |
GO:0003735 structural constituent of ribosome GO:0015101 organic cation transmembrane transporter activity GO:0015227 acyl carnitine transmembrane transporter activity GO:0015651 quaternary ammonium group transmembrane transporter activity |
Cellular Component |
GO:0005743 mitochondrial inner membrane |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | SLC25A29 |
Name | solute carrier family 25 (mitochondrial carnitine/acylcarnitine carrier), member 29 |
Aliases | FLJ38975; C14orf69; chromosome 14 open reading frame 69; solute carrier family 25, member 29; CACL; ORNT3; c ...... |
Chromosomal Location | 14q32.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between SLC25A29 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | SLC25A29 |
Name | solute carrier family 25 (mitochondrial carnitine/acylcarnitine carrier), member 29 |
Aliases | FLJ38975; C14orf69; chromosome 14 open reading frame 69; solute carrier family 25, member 29; CACL; ORNT3; c ...... |
Chromosomal Location | 14q32.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of SLC25A29 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | SLC25A29 |
Name | solute carrier family 25 (mitochondrial carnitine/acylcarnitine carrier), member 29 |
Aliases | FLJ38975; C14orf69; chromosome 14 open reading frame 69; solute carrier family 25, member 29; CACL; ORNT3; c ...... |
Chromosomal Location | 14q32.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of SLC25A29 in various data sets.
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There is no record. |
Summary | |
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Symbol | SLC25A29 |
Name | solute carrier family 25 (mitochondrial carnitine/acylcarnitine carrier), member 29 |
Aliases | FLJ38975; C14orf69; chromosome 14 open reading frame 69; solute carrier family 25, member 29; CACL; ORNT3; c ...... |
Chromosomal Location | 14q32.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SLC25A29. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | SLC25A29 |
Name | solute carrier family 25 (mitochondrial carnitine/acylcarnitine carrier), member 29 |
Aliases | FLJ38975; C14orf69; chromosome 14 open reading frame 69; solute carrier family 25, member 29; CACL; ORNT3; c ...... |
Chromosomal Location | 14q32.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SLC25A29. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SLC25A29. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | SLC25A29 |
Name | solute carrier family 25 (mitochondrial carnitine/acylcarnitine carrier), member 29 |
Aliases | FLJ38975; C14orf69; chromosome 14 open reading frame 69; solute carrier family 25, member 29; CACL; ORNT3; c ...... |
Chromosomal Location | 14q32.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SLC25A29. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | SLC25A29 |
Name | solute carrier family 25 (mitochondrial carnitine/acylcarnitine carrier), member 29 |
Aliases | FLJ38975; C14orf69; chromosome 14 open reading frame 69; solute carrier family 25, member 29; CACL; ORNT3; c ...... |
Chromosomal Location | 14q32.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of SLC25A29 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | SLC25A29 |
Name | solute carrier family 25 (mitochondrial carnitine/acylcarnitine carrier), member 29 |
Aliases | FLJ38975; C14orf69; chromosome 14 open reading frame 69; solute carrier family 25, member 29; CACL; ORNT3; c ...... |
Chromosomal Location | 14q32.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between SLC25A29 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | SLC25A29 |
Name | solute carrier family 25 (mitochondrial carnitine/acylcarnitine carrier), member 29 |
Aliases | FLJ38975; C14orf69; chromosome 14 open reading frame 69; solute carrier family 25, member 29; CACL; ORNT3; c ...... |
Chromosomal Location | 14q32.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting SLC25A29 collected from DrugBank database. |
Details on drugs targeting SLC25A29.
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