Summary | |
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Symbol | SLC27A6 |
Name | solute carrier family 27 (fatty acid transporter), member 6 |
Aliases | FATP6; VLCS-H1; FACVL2; ACSVL2; fatty-acid-Coenzyme A ligase, very long-chain 2; FATP-6; VLCSH1; fatty acid ...... |
Chromosomal Location | 5q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Membrane Multi-pass membrane protein Cell membrane, sarcolemma Note=In heart is exclusively located on the sarcolemma in areas juxtaposed with small blood vessels where it colocalizes CD36. |
Domain |
PF00501 AMP-binding enzyme PF13193 AMP-binding enzyme C-terminal domain |
Function |
Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. Thought to function as the predominant fatty acid protein transporter in heart. |
Biological Process |
GO:0000038 very long-chain fatty acid metabolic process GO:0001676 long-chain fatty acid metabolic process GO:0006631 fatty acid metabolic process GO:0006820 anion transport GO:0006869 lipid transport GO:0010876 lipid localization GO:0015711 organic anion transport GO:0015718 monocarboxylic acid transport GO:0015908 fatty acid transport GO:0015909 long-chain fatty acid transport GO:0046942 carboxylic acid transport |
Molecular Function |
GO:0004467 long-chain fatty acid-CoA ligase activity GO:0005319 lipid transporter activity GO:0015245 fatty acid transporter activity GO:0015645 fatty acid ligase activity GO:0016874 ligase activity GO:0016877 ligase activity, forming carbon-sulfur bonds GO:0031957 very long-chain fatty acid-CoA ligase activity |
Cellular Component |
GO:0042383 sarcolemma |
KEGG |
hsa03320 PPAR signaling pathway |
Reactome |
R-HSA-425407: SLC-mediated transmembrane transport R-HSA-382551: Transmembrane transport of small molecules R-HSA-804914: Transport of fatty acids R-HSA-425397: Transport of vitamins, nucleosides, and related molecules |
Summary | |
---|---|
Symbol | SLC27A6 |
Name | solute carrier family 27 (fatty acid transporter), member 6 |
Aliases | FATP6; VLCS-H1; FACVL2; ACSVL2; fatty-acid-Coenzyme A ligase, very long-chain 2; FATP-6; VLCSH1; fatty acid ...... |
Chromosomal Location | 5q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between SLC27A6 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | SLC27A6 |
Name | solute carrier family 27 (fatty acid transporter), member 6 |
Aliases | FATP6; VLCS-H1; FACVL2; ACSVL2; fatty-acid-Coenzyme A ligase, very long-chain 2; FATP-6; VLCSH1; fatty acid ...... |
Chromosomal Location | 5q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of SLC27A6 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | SLC27A6 |
Name | solute carrier family 27 (fatty acid transporter), member 6 |
Aliases | FATP6; VLCS-H1; FACVL2; ACSVL2; fatty-acid-Coenzyme A ligase, very long-chain 2; FATP-6; VLCSH1; fatty acid ...... |
Chromosomal Location | 5q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of SLC27A6 in various data sets.
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Points in the above scatter plot represent the mutation difference of SLC27A6 in various data sets.
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Summary | |
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Symbol | SLC27A6 |
Name | solute carrier family 27 (fatty acid transporter), member 6 |
Aliases | FATP6; VLCS-H1; FACVL2; ACSVL2; fatty-acid-Coenzyme A ligase, very long-chain 2; FATP-6; VLCSH1; fatty acid ...... |
Chromosomal Location | 5q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SLC27A6. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | SLC27A6 |
Name | solute carrier family 27 (fatty acid transporter), member 6 |
Aliases | FATP6; VLCS-H1; FACVL2; ACSVL2; fatty-acid-Coenzyme A ligase, very long-chain 2; FATP-6; VLCSH1; fatty acid ...... |
Chromosomal Location | 5q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SLC27A6. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SLC27A6. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | SLC27A6 |
Name | solute carrier family 27 (fatty acid transporter), member 6 |
Aliases | FATP6; VLCS-H1; FACVL2; ACSVL2; fatty-acid-Coenzyme A ligase, very long-chain 2; FATP-6; VLCSH1; fatty acid ...... |
Chromosomal Location | 5q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SLC27A6. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | SLC27A6 |
Name | solute carrier family 27 (fatty acid transporter), member 6 |
Aliases | FATP6; VLCS-H1; FACVL2; ACSVL2; fatty-acid-Coenzyme A ligase, very long-chain 2; FATP-6; VLCSH1; fatty acid ...... |
Chromosomal Location | 5q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of SLC27A6 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | SLC27A6 |
Name | solute carrier family 27 (fatty acid transporter), member 6 |
Aliases | FATP6; VLCS-H1; FACVL2; ACSVL2; fatty-acid-Coenzyme A ligase, very long-chain 2; FATP-6; VLCSH1; fatty acid ...... |
Chromosomal Location | 5q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between SLC27A6 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | SLC27A6 |
Name | solute carrier family 27 (fatty acid transporter), member 6 |
Aliases | FATP6; VLCS-H1; FACVL2; ACSVL2; fatty-acid-Coenzyme A ligase, very long-chain 2; FATP-6; VLCSH1; fatty acid ...... |
Chromosomal Location | 5q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting SLC27A6 collected from DrugBank database. |
There is no record. |