Summary | |
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Symbol | SLC38A5 |
Name | solute carrier family 38, member 5 |
Aliases | SN2; JM24; SNAT5; pp7194; solute carrier family 38 (amino acid transporter), member 5; system N transporter ...... |
Chromosomal Location | Xp11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane Multi-pass membrane protein |
Domain |
PF01490 Transmembrane amino acid transporter protein |
Function |
Functions as a sodium-dependent amino acid transporter which countertransport protons. Mediates the saturable, pH-sensitive, and electrogenic cotransport of several neutral amino acids including glycine, asparagine, alanine, serine, glutamine and histidine with sodium. |
Biological Process |
GO:0003333 amino acid transmembrane transport GO:0006820 anion transport GO:0006865 amino acid transport GO:0015711 organic anion transport GO:0015804 neutral amino acid transport GO:0015816 glycine transport GO:0015849 organic acid transport GO:0046942 carboxylic acid transport GO:1903825 organic acid transmembrane transport GO:1905039 carboxylic acid transmembrane transport |
Molecular Function |
GO:0005342 organic acid transmembrane transporter activity GO:0015171 amino acid transmembrane transporter activity GO:0015175 neutral amino acid transmembrane transporter activity GO:0015179 L-amino acid transmembrane transporter activity GO:0015187 glycine transmembrane transporter activity GO:0046943 carboxylic acid transmembrane transporter activity |
Cellular Component | - |
KEGG |
hsa04727 GABAergic synapse |
Reactome |
R-HSA-425374: Amino acid and oligopeptide SLC transporters R-HSA-352230: Amino acid transport across the plasma membrane R-HSA-425407: SLC-mediated transmembrane transport R-HSA-382551: Transmembrane transport of small molecules R-HSA-425393: Transport of inorganic cations/anions and amino acids/oligopeptides |
Summary | |
---|---|
Symbol | SLC38A5 |
Name | solute carrier family 38, member 5 |
Aliases | SN2; JM24; SNAT5; pp7194; solute carrier family 38 (amino acid transporter), member 5; system N transporter ...... |
Chromosomal Location | Xp11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between SLC38A5 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | SLC38A5 |
Name | solute carrier family 38, member 5 |
Aliases | SN2; JM24; SNAT5; pp7194; solute carrier family 38 (amino acid transporter), member 5; system N transporter ...... |
Chromosomal Location | Xp11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of SLC38A5 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | SLC38A5 |
Name | solute carrier family 38, member 5 |
Aliases | SN2; JM24; SNAT5; pp7194; solute carrier family 38 (amino acid transporter), member 5; system N transporter ...... |
Chromosomal Location | Xp11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of SLC38A5 in various data sets.
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Points in the above scatter plot represent the mutation difference of SLC38A5 in various data sets.
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Summary | |
---|---|
Symbol | SLC38A5 |
Name | solute carrier family 38, member 5 |
Aliases | SN2; JM24; SNAT5; pp7194; solute carrier family 38 (amino acid transporter), member 5; system N transporter ...... |
Chromosomal Location | Xp11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SLC38A5. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | SLC38A5 |
Name | solute carrier family 38, member 5 |
Aliases | SN2; JM24; SNAT5; pp7194; solute carrier family 38 (amino acid transporter), member 5; system N transporter ...... |
Chromosomal Location | Xp11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SLC38A5. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SLC38A5. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | SLC38A5 |
Name | solute carrier family 38, member 5 |
Aliases | SN2; JM24; SNAT5; pp7194; solute carrier family 38 (amino acid transporter), member 5; system N transporter ...... |
Chromosomal Location | Xp11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SLC38A5. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | SLC38A5 |
Name | solute carrier family 38, member 5 |
Aliases | SN2; JM24; SNAT5; pp7194; solute carrier family 38 (amino acid transporter), member 5; system N transporter ...... |
Chromosomal Location | Xp11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of SLC38A5 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | SLC38A5 |
Name | solute carrier family 38, member 5 |
Aliases | SN2; JM24; SNAT5; pp7194; solute carrier family 38 (amino acid transporter), member 5; system N transporter ...... |
Chromosomal Location | Xp11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between SLC38A5 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | SLC38A5 |
Name | solute carrier family 38, member 5 |
Aliases | SN2; JM24; SNAT5; pp7194; solute carrier family 38 (amino acid transporter), member 5; system N transporter ...... |
Chromosomal Location | Xp11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting SLC38A5 collected from DrugBank database. |
There is no record. |