Summary | |
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Symbol | SLC47A2 |
Name | solute carrier family 47 (multidrug and toxin extrusion), member 2 |
Aliases | FLJ31196; MATE2; MATE2-K; multidrug and toxin extrusion 2; MATE2-B; MATE2K; H+/organic cation antiporter; MA ...... |
Chromosomal Location | 17p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane Multi-pass membrane protein Note=Localized at the brush border membranes of the proximal tubules. |
Domain |
PF01554 MatE |
Function |
Solute transporter for tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, N-methylnicotinamide, metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, and ganciclovir. Responsible for the secretion of cationic drugs across the brush border membranes. |
Biological Process |
GO:0006855 drug transmembrane transport GO:0015893 drug transport GO:0042493 response to drug GO:0046618 drug export |
Molecular Function |
GO:0015077 monovalent inorganic cation transmembrane transporter activity GO:0015078 hydrogen ion transmembrane transporter activity GO:0015238 drug transmembrane transporter activity GO:0015291 secondary active transmembrane transporter activity GO:0015297 antiporter activity GO:0015298 solute:cation antiporter activity GO:0015299 solute:proton antiporter activity GO:0015307 drug:proton antiporter activity GO:0022804 active transmembrane transporter activity GO:0090484 drug transporter activity |
Cellular Component | - |
KEGG | - |
Reactome |
R-HSA-425471: Bile salt and organic anion SLC transporters R-HSA-425407: SLC-mediated transmembrane transport R-HSA-382551: Transmembrane transport of small molecules R-HSA-425366: Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds |
Summary | |
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Symbol | SLC47A2 |
Name | solute carrier family 47 (multidrug and toxin extrusion), member 2 |
Aliases | FLJ31196; MATE2; MATE2-K; multidrug and toxin extrusion 2; MATE2-B; MATE2K; H+/organic cation antiporter; MA ...... |
Chromosomal Location | 17p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between SLC47A2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | SLC47A2 |
Name | solute carrier family 47 (multidrug and toxin extrusion), member 2 |
Aliases | FLJ31196; MATE2; MATE2-K; multidrug and toxin extrusion 2; MATE2-B; MATE2K; H+/organic cation antiporter; MA ...... |
Chromosomal Location | 17p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of SLC47A2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | SLC47A2 |
Name | solute carrier family 47 (multidrug and toxin extrusion), member 2 |
Aliases | FLJ31196; MATE2; MATE2-K; multidrug and toxin extrusion 2; MATE2-B; MATE2K; H+/organic cation antiporter; MA ...... |
Chromosomal Location | 17p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of SLC47A2 in various data sets.
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Points in the above scatter plot represent the mutation difference of SLC47A2 in various data sets.
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Summary | |
---|---|
Symbol | SLC47A2 |
Name | solute carrier family 47 (multidrug and toxin extrusion), member 2 |
Aliases | FLJ31196; MATE2; MATE2-K; multidrug and toxin extrusion 2; MATE2-B; MATE2K; H+/organic cation antiporter; MA ...... |
Chromosomal Location | 17p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SLC47A2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | SLC47A2 |
Name | solute carrier family 47 (multidrug and toxin extrusion), member 2 |
Aliases | FLJ31196; MATE2; MATE2-K; multidrug and toxin extrusion 2; MATE2-B; MATE2K; H+/organic cation antiporter; MA ...... |
Chromosomal Location | 17p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SLC47A2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SLC47A2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | SLC47A2 |
Name | solute carrier family 47 (multidrug and toxin extrusion), member 2 |
Aliases | FLJ31196; MATE2; MATE2-K; multidrug and toxin extrusion 2; MATE2-B; MATE2K; H+/organic cation antiporter; MA ...... |
Chromosomal Location | 17p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SLC47A2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | SLC47A2 |
Name | solute carrier family 47 (multidrug and toxin extrusion), member 2 |
Aliases | FLJ31196; MATE2; MATE2-K; multidrug and toxin extrusion 2; MATE2-B; MATE2K; H+/organic cation antiporter; MA ...... |
Chromosomal Location | 17p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of SLC47A2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | SLC47A2 |
Name | solute carrier family 47 (multidrug and toxin extrusion), member 2 |
Aliases | FLJ31196; MATE2; MATE2-K; multidrug and toxin extrusion 2; MATE2-B; MATE2K; H+/organic cation antiporter; MA ...... |
Chromosomal Location | 17p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between SLC47A2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | SLC47A2 |
Name | solute carrier family 47 (multidrug and toxin extrusion), member 2 |
Aliases | FLJ31196; MATE2; MATE2-K; multidrug and toxin extrusion 2; MATE2-B; MATE2K; H+/organic cation antiporter; MA ...... |
Chromosomal Location | 17p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting SLC47A2 collected from DrugBank database. |
There is no record. |