Summary | |
---|---|
Symbol | SLC4A10 |
Name | solute carrier family 4, sodium bicarbonate transporter, member 10 |
Aliases | NBCn2; NCBE; solute carrier family 4, sodium bicarbonate transporter-like, member 10; solute carrier family ...... |
Chromosomal Location | 2q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane; Multi-pass membrane protein. Note=Localizes to the basolateral membrane. |
Domain |
PF07565 Band 3 cytoplasmic domain PF00955 HCO3- transporter family |
Function |
Electrogenic sodium/bicarbonate cotransporter in exchange for intracellular chloride. Plays an important role in regulating intracellular pH (By similarity). |
Biological Process |
GO:0006814 sodium ion transport GO:0006818 hydrogen transport GO:0006820 anion transport GO:0006821 chloride transport GO:0006885 regulation of pH GO:0007626 locomotory behavior GO:0009314 response to radiation GO:0009416 response to light stimulus GO:0009791 post-embryonic development GO:0015672 monovalent inorganic cation transport GO:0015698 inorganic anion transport GO:0015701 bicarbonate transport GO:0015711 organic anion transport GO:0015992 proton transport GO:0021859 pyramidal neuron differentiation GO:0021860 pyramidal neuron development GO:0021872 forebrain generation of neurons GO:0021879 forebrain neuron differentiation GO:0021884 forebrain neuron development GO:0021953 central nervous system neuron differentiation GO:0021954 central nervous system neuron development GO:0030004 cellular monovalent inorganic cation homeostasis GO:0030641 regulation of cellular pH GO:0030900 forebrain development GO:0035264 multicellular organism growth GO:0035640 exploration behavior GO:0035641 locomotory exploration behavior GO:0044708 single-organism behavior GO:0048854 brain morphogenesis GO:0051453 regulation of intracellular pH GO:0055067 monovalent inorganic cation homeostasis GO:0098656 anion transmembrane transport GO:1902600 hydrogen ion transmembrane transport |
Molecular Function |
GO:0005452 inorganic anion exchanger activity GO:0008509 anion transmembrane transporter activity GO:0015103 inorganic anion transmembrane transporter activity GO:0015291 secondary active transmembrane transporter activity GO:0015293 symporter activity GO:0015297 antiporter activity GO:0015301 anion:anion antiporter activity GO:0022804 active transmembrane transporter activity GO:0099516 ion antiporter activity |
Cellular Component |
GO:0016323 basolateral plasma membrane GO:0030425 dendrite GO:0043025 neuronal cell body GO:0044297 cell body GO:0097440 apical dendrite GO:0097441 basilar dendrite GO:0097442 CA3 pyramidal cell dendrite |
KEGG | - |
Reactome |
R-HSA-425381: Bicarbonate transporters R-HSA-425407: SLC-mediated transmembrane transport R-HSA-382551: Transmembrane transport of small molecules R-HSA-425393: Transport of inorganic cations/anions and amino acids/oligopeptides |
Summary | |
---|---|
Symbol | SLC4A10 |
Name | solute carrier family 4, sodium bicarbonate transporter, member 10 |
Aliases | NBCn2; NCBE; solute carrier family 4, sodium bicarbonate transporter-like, member 10; solute carrier family ...... |
Chromosomal Location | 2q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between SLC4A10 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | SLC4A10 |
Name | solute carrier family 4, sodium bicarbonate transporter, member 10 |
Aliases | NBCn2; NCBE; solute carrier family 4, sodium bicarbonate transporter-like, member 10; solute carrier family ...... |
Chromosomal Location | 2q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
[ TOP ]
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Statistical results of SLC4A10 in screening data sets for detecting immune reponses.
|
Summary | |
---|---|
Symbol | SLC4A10 |
Name | solute carrier family 4, sodium bicarbonate transporter, member 10 |
Aliases | NBCn2; NCBE; solute carrier family 4, sodium bicarbonate transporter-like, member 10; solute carrier family ...... |
Chromosomal Location | 2q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of SLC4A10 in various data sets.
|
Points in the above scatter plot represent the mutation difference of SLC4A10 in various data sets.
|
Summary | |
---|---|
Symbol | SLC4A10 |
Name | solute carrier family 4, sodium bicarbonate transporter, member 10 |
Aliases | NBCn2; NCBE; solute carrier family 4, sodium bicarbonate transporter-like, member 10; solute carrier family ...... |
Chromosomal Location | 2q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SLC4A10. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | SLC4A10 |
Name | solute carrier family 4, sodium bicarbonate transporter, member 10 |
Aliases | NBCn2; NCBE; solute carrier family 4, sodium bicarbonate transporter-like, member 10; solute carrier family ...... |
Chromosomal Location | 2q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SLC4A10. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SLC4A10. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | SLC4A10 |
Name | solute carrier family 4, sodium bicarbonate transporter, member 10 |
Aliases | NBCn2; NCBE; solute carrier family 4, sodium bicarbonate transporter-like, member 10; solute carrier family ...... |
Chromosomal Location | 2q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SLC4A10. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | SLC4A10 |
Name | solute carrier family 4, sodium bicarbonate transporter, member 10 |
Aliases | NBCn2; NCBE; solute carrier family 4, sodium bicarbonate transporter-like, member 10; solute carrier family ...... |
Chromosomal Location | 2q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of SLC4A10 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | SLC4A10 |
Name | solute carrier family 4, sodium bicarbonate transporter, member 10 |
Aliases | NBCn2; NCBE; solute carrier family 4, sodium bicarbonate transporter-like, member 10; solute carrier family ...... |
Chromosomal Location | 2q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between SLC4A10 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | SLC4A10 |
Name | solute carrier family 4, sodium bicarbonate transporter, member 10 |
Aliases | NBCn2; NCBE; solute carrier family 4, sodium bicarbonate transporter-like, member 10; solute carrier family ...... |
Chromosomal Location | 2q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting SLC4A10 collected from DrugBank database. |
There is no record. |