Summary | |
---|---|
Symbol | SLC4A4 |
Name | solute carrier family 4 (sodium bicarbonate cotransporter), member 4 |
Aliases | NBC1; HNBC1; pNBC; hhNMC; solute carrier family 4, sodium bicarbonate cotransporter, member 4; KNBC; NBCe1-A ...... |
Chromosomal Location | 4q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Basolateral cell membrane Multi-pass membrane protein |
Domain |
PF07565 Band 3 cytoplasmic domain PF00955 HCO3- transporter family |
Function |
Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH. ; FUNCTION: Isoform 2: May have a higher activity than isoform 1. |
Biological Process |
GO:0006814 sodium ion transport GO:0006820 anion transport GO:0006885 regulation of pH GO:0015672 monovalent inorganic cation transport GO:0015698 inorganic anion transport GO:0015701 bicarbonate transport GO:0015711 organic anion transport GO:0030004 cellular monovalent inorganic cation homeostasis GO:0030641 regulation of cellular pH GO:0035725 sodium ion transmembrane transport GO:0051453 regulation of intracellular pH GO:0055067 monovalent inorganic cation homeostasis GO:0098656 anion transmembrane transport |
Molecular Function |
GO:0005452 inorganic anion exchanger activity GO:0008509 anion transmembrane transporter activity GO:0008510 sodium:bicarbonate symporter activity GO:0008514 organic anion transmembrane transporter activity GO:0015077 monovalent inorganic cation transmembrane transporter activity GO:0015081 sodium ion transmembrane transporter activity GO:0015103 inorganic anion transmembrane transporter activity GO:0015106 bicarbonate transmembrane transporter activity GO:0015291 secondary active transmembrane transporter activity GO:0015293 symporter activity GO:0015294 solute:cation symporter activity GO:0015296 anion:cation symporter activity GO:0022804 active transmembrane transporter activity GO:0022853 active ion transmembrane transporter activity GO:0046873 metal ion transmembrane transporter activity |
Cellular Component |
GO:0016323 basolateral plasma membrane |
KEGG |
hsa04964 Proximal tubule bicarbonate reclamation hsa04972 Pancreatic secretion hsa04976 Bile secretion |
Reactome |
R-HSA-425381: Bicarbonate transporters R-HSA-425407: SLC-mediated transmembrane transport R-HSA-382551: Transmembrane transport of small molecules R-HSA-425393: Transport of inorganic cations/anions and amino acids/oligopeptides |
Summary | |
---|---|
Symbol | SLC4A4 |
Name | solute carrier family 4 (sodium bicarbonate cotransporter), member 4 |
Aliases | NBC1; HNBC1; pNBC; hhNMC; solute carrier family 4, sodium bicarbonate cotransporter, member 4; KNBC; NBCe1-A ...... |
Chromosomal Location | 4q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between SLC4A4 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | SLC4A4 |
Name | solute carrier family 4 (sodium bicarbonate cotransporter), member 4 |
Aliases | NBC1; HNBC1; pNBC; hhNMC; solute carrier family 4, sodium bicarbonate cotransporter, member 4; KNBC; NBCe1-A ...... |
Chromosomal Location | 4q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
[ TOP ]
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Statistical results of SLC4A4 in screening data sets for detecting immune reponses.
|
Summary | |
---|---|
Symbol | SLC4A4 |
Name | solute carrier family 4 (sodium bicarbonate cotransporter), member 4 |
Aliases | NBC1; HNBC1; pNBC; hhNMC; solute carrier family 4, sodium bicarbonate cotransporter, member 4; KNBC; NBCe1-A ...... |
Chromosomal Location | 4q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of SLC4A4 in various data sets.
|
Points in the above scatter plot represent the mutation difference of SLC4A4 in various data sets.
|
Summary | |
---|---|
Symbol | SLC4A4 |
Name | solute carrier family 4 (sodium bicarbonate cotransporter), member 4 |
Aliases | NBC1; HNBC1; pNBC; hhNMC; solute carrier family 4, sodium bicarbonate cotransporter, member 4; KNBC; NBCe1-A ...... |
Chromosomal Location | 4q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SLC4A4. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | SLC4A4 |
Name | solute carrier family 4 (sodium bicarbonate cotransporter), member 4 |
Aliases | NBC1; HNBC1; pNBC; hhNMC; solute carrier family 4, sodium bicarbonate cotransporter, member 4; KNBC; NBCe1-A ...... |
Chromosomal Location | 4q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SLC4A4. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SLC4A4. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | SLC4A4 |
Name | solute carrier family 4 (sodium bicarbonate cotransporter), member 4 |
Aliases | NBC1; HNBC1; pNBC; hhNMC; solute carrier family 4, sodium bicarbonate cotransporter, member 4; KNBC; NBCe1-A ...... |
Chromosomal Location | 4q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SLC4A4. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | SLC4A4 |
Name | solute carrier family 4 (sodium bicarbonate cotransporter), member 4 |
Aliases | NBC1; HNBC1; pNBC; hhNMC; solute carrier family 4, sodium bicarbonate cotransporter, member 4; KNBC; NBCe1-A ...... |
Chromosomal Location | 4q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of SLC4A4 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | SLC4A4 |
Name | solute carrier family 4 (sodium bicarbonate cotransporter), member 4 |
Aliases | NBC1; HNBC1; pNBC; hhNMC; solute carrier family 4, sodium bicarbonate cotransporter, member 4; KNBC; NBCe1-A ...... |
Chromosomal Location | 4q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between SLC4A4 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | SLC4A4 |
Name | solute carrier family 4 (sodium bicarbonate cotransporter), member 4 |
Aliases | NBC1; HNBC1; pNBC; hhNMC; solute carrier family 4, sodium bicarbonate cotransporter, member 4; KNBC; NBCe1-A ...... |
Chromosomal Location | 4q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting SLC4A4 collected from DrugBank database. |
There is no record. |