Summary | |
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Symbol | SLC51B |
Name | solute carrier family 51, beta subunit |
Aliases | OSTbeta; organic solute transporter beta subunit; OSTB; OST-beta; solute carrier family 51 subunit beta; Org ...... |
Chromosomal Location | 15q22.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane Single-pass membrane protein Note=Mainly restricted to the lateral and basal membranes of ileal enterocytes. |
Domain |
PF15048 Organic solute transporter subunit beta protein |
Function |
Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. Efficiently transports the major species of bile acids. Modulates SLC51A glycosylation, membrane trafficking and stability activities. |
Biological Process |
GO:0006486 protein glycosylation GO:0006612 protein targeting to membrane GO:0006820 anion transport GO:0006869 lipid transport GO:0009100 glycoprotein metabolic process GO:0009101 glycoprotein biosynthetic process GO:0010559 regulation of glycoprotein biosynthetic process GO:0010560 positive regulation of glycoprotein biosynthetic process GO:0010876 lipid localization GO:0015711 organic anion transport GO:0015718 monocarboxylic acid transport GO:0015721 bile acid and bile salt transport GO:0015849 organic acid transport GO:0015850 organic hydroxy compound transport GO:0031647 regulation of protein stability GO:0032386 regulation of intracellular transport GO:0032388 positive regulation of intracellular transport GO:0032527 protein exit from endoplasmic reticulum GO:0033157 regulation of intracellular protein transport GO:0043413 macromolecule glycosylation GO:0046942 carboxylic acid transport GO:0051222 positive regulation of protein transport GO:0060049 regulation of protein glycosylation GO:0060050 positive regulation of protein glycosylation GO:0070085 glycosylation GO:0070861 regulation of protein exit from endoplasmic reticulum GO:0070863 positive regulation of protein exit from endoplasmic reticulum GO:0072657 protein localization to membrane GO:0090150 establishment of protein localization to membrane GO:0090313 regulation of protein targeting to membrane GO:0090314 positive regulation of protein targeting to membrane GO:0090316 positive regulation of intracellular protein transport GO:1903018 regulation of glycoprotein metabolic process GO:1903020 positive regulation of glycoprotein metabolic process GO:1903533 regulation of protein targeting GO:1903829 positive regulation of cellular protein localization GO:1904951 positive regulation of establishment of protein localization |
Molecular Function |
GO:0046982 protein heterodimerization activity |
Cellular Component | - |
KEGG |
hsa04976 Bile secretion |
Reactome | - |
Summary | |
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Symbol | SLC51B |
Name | solute carrier family 51, beta subunit |
Aliases | OSTbeta; organic solute transporter beta subunit; OSTB; OST-beta; solute carrier family 51 subunit beta; Org ...... |
Chromosomal Location | 15q22.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between SLC51B and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | SLC51B |
Name | solute carrier family 51, beta subunit |
Aliases | OSTbeta; organic solute transporter beta subunit; OSTB; OST-beta; solute carrier family 51 subunit beta; Org ...... |
Chromosomal Location | 15q22.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of SLC51B in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | SLC51B |
Name | solute carrier family 51, beta subunit |
Aliases | OSTbeta; organic solute transporter beta subunit; OSTB; OST-beta; solute carrier family 51 subunit beta; Org ...... |
Chromosomal Location | 15q22.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of SLC51B in various data sets.
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Points in the above scatter plot represent the mutation difference of SLC51B in various data sets.
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Summary | |
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Symbol | SLC51B |
Name | solute carrier family 51, beta subunit |
Aliases | OSTbeta; organic solute transporter beta subunit; OSTB; OST-beta; solute carrier family 51 subunit beta; Org ...... |
Chromosomal Location | 15q22.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SLC51B. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | SLC51B |
Name | solute carrier family 51, beta subunit |
Aliases | OSTbeta; organic solute transporter beta subunit; OSTB; OST-beta; solute carrier family 51 subunit beta; Org ...... |
Chromosomal Location | 15q22.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SLC51B. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SLC51B. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | SLC51B |
Name | solute carrier family 51, beta subunit |
Aliases | OSTbeta; organic solute transporter beta subunit; OSTB; OST-beta; solute carrier family 51 subunit beta; Org ...... |
Chromosomal Location | 15q22.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SLC51B. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | SLC51B |
Name | solute carrier family 51, beta subunit |
Aliases | OSTbeta; organic solute transporter beta subunit; OSTB; OST-beta; solute carrier family 51 subunit beta; Org ...... |
Chromosomal Location | 15q22.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of SLC51B expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | SLC51B |
Name | solute carrier family 51, beta subunit |
Aliases | OSTbeta; organic solute transporter beta subunit; OSTB; OST-beta; solute carrier family 51 subunit beta; Org ...... |
Chromosomal Location | 15q22.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between SLC51B and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | SLC51B |
Name | solute carrier family 51, beta subunit |
Aliases | OSTbeta; organic solute transporter beta subunit; OSTB; OST-beta; solute carrier family 51 subunit beta; Org ...... |
Chromosomal Location | 15q22.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting SLC51B collected from DrugBank database. |
There is no record. |