Summary | |
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Symbol | SLC5A11 |
Name | solute carrier family 5 (sodium/inositol cotransporter), member 11 |
Aliases | KST1; SGLT6; solute carrier family 5 (sodium/glucose cotransporter), member 11; RKST1; Na(+)/myo-inositol co ...... |
Chromosomal Location | 16p12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Membrane Multi-pass membrane protein |
Domain |
PF00474 Sodium |
Function |
Involved in the sodium-dependent cotransport of myo-inositol (MI) with a Na(+):MI stoichiometry of 2:1. Exclusively responsible for apical MI transport and absorption in intestine. Also can transport D-chiro-inositol (DCI) but not L-fructose. Exhibits stereospecific cotransport of both D-glucose and D-xylose. May induce apoptosis through the TNF-alpha, PDCD1 pathway. May play a role in the regulation of MI concentration in serum, involving reabsorption in at least the proximal tubule of the kidney. |
Biological Process |
GO:0006814 sodium ion transport GO:0008643 carbohydrate transport GO:0015672 monovalent inorganic cation transport GO:0015791 polyol transport GO:0015850 organic hydroxy compound transport |
Molecular Function |
GO:0015166 polyol transmembrane transporter activity GO:0015291 secondary active transmembrane transporter activity GO:0015293 symporter activity GO:0015665 alcohol transmembrane transporter activity GO:0022804 active transmembrane transporter activity GO:1901618 organic hydroxy compound transmembrane transporter activity |
Cellular Component | - |
KEGG | - |
Reactome |
R-HSA-429593: Inositol transporters R-HSA-425407: SLC-mediated transmembrane transport R-HSA-382551: Transmembrane transport of small molecules R-HSA-425366: Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds |
Summary | |
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Symbol | SLC5A11 |
Name | solute carrier family 5 (sodium/inositol cotransporter), member 11 |
Aliases | KST1; SGLT6; solute carrier family 5 (sodium/glucose cotransporter), member 11; RKST1; Na(+)/myo-inositol co ...... |
Chromosomal Location | 16p12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between SLC5A11 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | SLC5A11 |
Name | solute carrier family 5 (sodium/inositol cotransporter), member 11 |
Aliases | KST1; SGLT6; solute carrier family 5 (sodium/glucose cotransporter), member 11; RKST1; Na(+)/myo-inositol co ...... |
Chromosomal Location | 16p12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of SLC5A11 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | SLC5A11 |
Name | solute carrier family 5 (sodium/inositol cotransporter), member 11 |
Aliases | KST1; SGLT6; solute carrier family 5 (sodium/glucose cotransporter), member 11; RKST1; Na(+)/myo-inositol co ...... |
Chromosomal Location | 16p12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of SLC5A11 in various data sets.
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Points in the above scatter plot represent the mutation difference of SLC5A11 in various data sets.
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Summary | |
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Symbol | SLC5A11 |
Name | solute carrier family 5 (sodium/inositol cotransporter), member 11 |
Aliases | KST1; SGLT6; solute carrier family 5 (sodium/glucose cotransporter), member 11; RKST1; Na(+)/myo-inositol co ...... |
Chromosomal Location | 16p12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SLC5A11. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | SLC5A11 |
Name | solute carrier family 5 (sodium/inositol cotransporter), member 11 |
Aliases | KST1; SGLT6; solute carrier family 5 (sodium/glucose cotransporter), member 11; RKST1; Na(+)/myo-inositol co ...... |
Chromosomal Location | 16p12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SLC5A11. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SLC5A11. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | SLC5A11 |
Name | solute carrier family 5 (sodium/inositol cotransporter), member 11 |
Aliases | KST1; SGLT6; solute carrier family 5 (sodium/glucose cotransporter), member 11; RKST1; Na(+)/myo-inositol co ...... |
Chromosomal Location | 16p12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SLC5A11. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | SLC5A11 |
Name | solute carrier family 5 (sodium/inositol cotransporter), member 11 |
Aliases | KST1; SGLT6; solute carrier family 5 (sodium/glucose cotransporter), member 11; RKST1; Na(+)/myo-inositol co ...... |
Chromosomal Location | 16p12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of SLC5A11 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | SLC5A11 |
Name | solute carrier family 5 (sodium/inositol cotransporter), member 11 |
Aliases | KST1; SGLT6; solute carrier family 5 (sodium/glucose cotransporter), member 11; RKST1; Na(+)/myo-inositol co ...... |
Chromosomal Location | 16p12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between SLC5A11 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | SLC5A11 |
Name | solute carrier family 5 (sodium/inositol cotransporter), member 11 |
Aliases | KST1; SGLT6; solute carrier family 5 (sodium/glucose cotransporter), member 11; RKST1; Na(+)/myo-inositol co ...... |
Chromosomal Location | 16p12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting SLC5A11 collected from DrugBank database. |
There is no record. |