Summary | |
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Symbol | SLC5A5 |
Name | solute carrier family 5 (sodium/iodide cotransporter), member 5 |
Aliases | NIS; solute carrier family 5 (sodium iodide symporter), member 5; TDH1; Na(+)/I(-) cotransporter; Na(+)/I(-) ...... |
Chromosomal Location | 19p13.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Membrane; Multi-pass membrane protein. |
Domain |
PF00474 Sodium |
Function |
Mediates iodide uptake in the thyroid gland. |
Biological Process |
GO:0006575 cellular modified amino acid metabolic process GO:0006590 thyroid hormone generation GO:0006814 sodium ion transport GO:0006820 anion transport GO:0010817 regulation of hormone levels GO:0014074 response to purine-containing compound GO:0015672 monovalent inorganic cation transport GO:0015698 inorganic anion transport GO:0015705 iodide transport GO:0018958 phenol-containing compound metabolic process GO:0034698 response to gonadotropin GO:0035725 sodium ion transmembrane transport GO:0042403 thyroid hormone metabolic process GO:0042445 hormone metabolic process GO:0046683 response to organophosphorus GO:0051591 response to cAMP GO:0071320 cellular response to cAMP GO:0071371 cellular response to gonadotropin stimulus GO:0071407 cellular response to organic cyclic compound GO:0071417 cellular response to organonitrogen compound GO:0098656 anion transmembrane transport GO:1901615 organic hydroxy compound metabolic process |
Molecular Function |
GO:0008507 sodium:iodide symporter activity GO:0008509 anion transmembrane transporter activity GO:0015077 monovalent inorganic cation transmembrane transporter activity GO:0015081 sodium ion transmembrane transporter activity GO:0015103 inorganic anion transmembrane transporter activity GO:0015111 iodide transmembrane transporter activity GO:0015291 secondary active transmembrane transporter activity GO:0015293 symporter activity GO:0015294 solute:cation symporter activity GO:0015296 anion:cation symporter activity GO:0015370 solute:sodium symporter activity GO:0015373 monovalent anion:sodium symporter activity GO:0022804 active transmembrane transporter activity GO:0022853 active ion transmembrane transporter activity GO:0046873 metal ion transmembrane transporter activity |
Cellular Component | - |
KEGG |
hsa04918 Thyroid hormone synthesis |
Reactome |
R-HSA-209776: Amine-derived hormones R-HSA-425374: Amino acid and oligopeptide SLC transporters R-HSA-1430728: Metabolism R-HSA-71291: Metabolism of amino acids and derivatives R-HSA-428643: Organic anion transporters R-HSA-425407: SLC-mediated transmembrane transport R-HSA-209968: Thyroxine biosynthesis R-HSA-382551: Transmembrane transport of small molecules R-HSA-425393: Transport of inorganic cations/anions and amino acids/oligopeptides |
Summary | |
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Symbol | SLC5A5 |
Name | solute carrier family 5 (sodium/iodide cotransporter), member 5 |
Aliases | NIS; solute carrier family 5 (sodium iodide symporter), member 5; TDH1; Na(+)/I(-) cotransporter; Na(+)/I(-) ...... |
Chromosomal Location | 19p13.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between SLC5A5 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between SLC5A5 and anti-tumor immunity in human cancer.
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Summary | |
---|---|
Symbol | SLC5A5 |
Name | solute carrier family 5 (sodium/iodide cotransporter), member 5 |
Aliases | NIS; solute carrier family 5 (sodium iodide symporter), member 5; TDH1; Na(+)/I(-) cotransporter; Na(+)/I(-) ...... |
Chromosomal Location | 19p13.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of SLC5A5 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | SLC5A5 |
Name | solute carrier family 5 (sodium/iodide cotransporter), member 5 |
Aliases | NIS; solute carrier family 5 (sodium iodide symporter), member 5; TDH1; Na(+)/I(-) cotransporter; Na(+)/I(-) ...... |
Chromosomal Location | 19p13.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of SLC5A5 in various data sets.
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Points in the above scatter plot represent the mutation difference of SLC5A5 in various data sets.
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Summary | |
---|---|
Symbol | SLC5A5 |
Name | solute carrier family 5 (sodium/iodide cotransporter), member 5 |
Aliases | NIS; solute carrier family 5 (sodium iodide symporter), member 5; TDH1; Na(+)/I(-) cotransporter; Na(+)/I(-) ...... |
Chromosomal Location | 19p13.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SLC5A5. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | SLC5A5 |
Name | solute carrier family 5 (sodium/iodide cotransporter), member 5 |
Aliases | NIS; solute carrier family 5 (sodium iodide symporter), member 5; TDH1; Na(+)/I(-) cotransporter; Na(+)/I(-) ...... |
Chromosomal Location | 19p13.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SLC5A5. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SLC5A5. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | SLC5A5 |
Name | solute carrier family 5 (sodium/iodide cotransporter), member 5 |
Aliases | NIS; solute carrier family 5 (sodium iodide symporter), member 5; TDH1; Na(+)/I(-) cotransporter; Na(+)/I(-) ...... |
Chromosomal Location | 19p13.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SLC5A5. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | SLC5A5 |
Name | solute carrier family 5 (sodium/iodide cotransporter), member 5 |
Aliases | NIS; solute carrier family 5 (sodium iodide symporter), member 5; TDH1; Na(+)/I(-) cotransporter; Na(+)/I(-) ...... |
Chromosomal Location | 19p13.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of SLC5A5 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | SLC5A5 |
Name | solute carrier family 5 (sodium/iodide cotransporter), member 5 |
Aliases | NIS; solute carrier family 5 (sodium iodide symporter), member 5; TDH1; Na(+)/I(-) cotransporter; Na(+)/I(-) ...... |
Chromosomal Location | 19p13.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between SLC5A5 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | SLC5A5 |
Name | solute carrier family 5 (sodium/iodide cotransporter), member 5 |
Aliases | NIS; solute carrier family 5 (sodium iodide symporter), member 5; TDH1; Na(+)/I(-) cotransporter; Na(+)/I(-) ...... |
Chromosomal Location | 19p13.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting SLC5A5 collected from DrugBank database. |
There is no record. |