Summary | |
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Symbol | SLC5A8 |
Name | solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8 |
Aliases | AIT; solute carrier family 5 (iodide transporter), member 8; SMCT; SMCT1; apical iodide transporter; electro ...... |
Chromosomal Location | 12q23.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Apical cell membrane Multi-pass membrane protein Note=Expressed at the apical membrane of normal tall thyrocytes and of colonic epithelial cells. |
Domain |
PF00474 Sodium |
Function |
Acts as an electrogenic sodium (Na(+)) and chloride (Cl-)-dependent sodium-coupled solute transporter, including transport of monocarboxylates (short-chain fatty acids including L-lactate, D-lactate, pyruvate, acetate, propionate, valerate and butyrate), lactate, mocarboxylate drugs (nicotinate, benzoate, salicylate and 5-aminosalicylate) and ketone bodies (beta-D-hydroxybutyrate, acetoacetate and alpha-ketoisocaproate), with a Na(+):substrate stoichiometry of between 4:1 and 2:1. Catalyzes passive carrier mediated diffusion of iodide. Mediates iodide transport from the thyrocyte into the colloid lumen through the apical membrane. May be responsible for the absorption of D-lactate and monocarboxylate drugs from the intestinal tract. Acts as a tumor suppressor, suppressing colony formation in colon cancer, prostate cancer and glioma cell lines. May play a critical role in the entry of L-lactate and ketone bodies into neurons by a process driven by an electrochemical Na(+) gradient and hence contribute to the maintenance of the energy status and function of neurons. |
Biological Process |
GO:0006814 sodium ion transport GO:0006820 anion transport GO:0015672 monovalent inorganic cation transport GO:0015711 organic anion transport GO:0015718 monocarboxylic acid transport GO:0046942 carboxylic acid transport |
Molecular Function |
GO:0005342 organic acid transmembrane transporter activity GO:0008028 monocarboxylic acid transmembrane transporter activity GO:0015291 secondary active transmembrane transporter activity GO:0015293 symporter activity GO:0022803 passive transmembrane transporter activity GO:0022804 active transmembrane transporter activity GO:0046943 carboxylic acid transmembrane transporter activity |
Cellular Component |
GO:0016324 apical plasma membrane GO:0045177 apical part of cell |
KEGG | - |
Reactome |
R-HSA-425374: Amino acid and oligopeptide SLC transporters R-HSA-1430728: Metabolism R-HSA-196854: Metabolism of vitamins and cofactors R-HSA-196849: Metabolism of water-soluble vitamins and cofactors R-HSA-197264: Nicotinamide salvaging R-HSA-196807: Nicotinate metabolism R-HSA-428643: Organic anion transporters R-HSA-425407: SLC-mediated transmembrane transport R-HSA-382551: Transmembrane transport of small molecules R-HSA-425393: Transport of inorganic cations/anions and amino acids/oligopeptides |
Summary | |
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Symbol | SLC5A8 |
Name | solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8 |
Aliases | AIT; solute carrier family 5 (iodide transporter), member 8; SMCT; SMCT1; apical iodide transporter; electro ...... |
Chromosomal Location | 12q23.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between SLC5A8 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between SLC5A8 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | SLC5A8 |
Name | solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8 |
Aliases | AIT; solute carrier family 5 (iodide transporter), member 8; SMCT; SMCT1; apical iodide transporter; electro ...... |
Chromosomal Location | 12q23.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of SLC5A8 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | SLC5A8 |
Name | solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8 |
Aliases | AIT; solute carrier family 5 (iodide transporter), member 8; SMCT; SMCT1; apical iodide transporter; electro ...... |
Chromosomal Location | 12q23.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of SLC5A8 in various data sets.
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Points in the above scatter plot represent the mutation difference of SLC5A8 in various data sets.
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Summary | |
---|---|
Symbol | SLC5A8 |
Name | solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8 |
Aliases | AIT; solute carrier family 5 (iodide transporter), member 8; SMCT; SMCT1; apical iodide transporter; electro ...... |
Chromosomal Location | 12q23.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SLC5A8. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | SLC5A8 |
Name | solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8 |
Aliases | AIT; solute carrier family 5 (iodide transporter), member 8; SMCT; SMCT1; apical iodide transporter; electro ...... |
Chromosomal Location | 12q23.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SLC5A8. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SLC5A8. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | SLC5A8 |
Name | solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8 |
Aliases | AIT; solute carrier family 5 (iodide transporter), member 8; SMCT; SMCT1; apical iodide transporter; electro ...... |
Chromosomal Location | 12q23.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SLC5A8. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | SLC5A8 |
Name | solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8 |
Aliases | AIT; solute carrier family 5 (iodide transporter), member 8; SMCT; SMCT1; apical iodide transporter; electro ...... |
Chromosomal Location | 12q23.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of SLC5A8 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | SLC5A8 |
Name | solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8 |
Aliases | AIT; solute carrier family 5 (iodide transporter), member 8; SMCT; SMCT1; apical iodide transporter; electro ...... |
Chromosomal Location | 12q23.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between SLC5A8 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | SLC5A8 |
Name | solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8 |
Aliases | AIT; solute carrier family 5 (iodide transporter), member 8; SMCT; SMCT1; apical iodide transporter; electro ...... |
Chromosomal Location | 12q23.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting SLC5A8 collected from DrugBank database. |
There is no record. |