Summary | |
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Symbol | SLC6A4 |
Name | solute carrier family 6 (neurotransmitter transporter), member 4 |
Aliases | 5-HTT; SERT1; serotonin transporter 1; OCD1; solute carrier family 6 (neurotransmitter transporter, serotoni ...... |
Chromosomal Location | 17q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane Multi-pass membrane protein Endomembrane system Multi-pass membrane protein Endosome membrane Multi-pass membrane protein Note=Could be part of recycling endosomes (PubMed:18227069, PubMed:16870614). Density of transporter molecules on the plasma membrane is itself regulated by STX1A (By similarity). Density of transporter molecules on the plasma membrane is also regulated by serotonin (PubMed:17506858) (PubMed:18227069). |
Domain |
PF03491 Serotonin (5-HT) neurotransmitter transporter PF00209 Sodium |
Function |
Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner. |
Biological Process |
GO:0001101 response to acid chemical GO:0001504 neurotransmitter uptake GO:0001505 regulation of neurotransmitter levels GO:0001666 response to hypoxia GO:0001963 synaptic transmission, dopaminergic GO:0003013 circulatory system process GO:0003018 vascular process in circulatory system GO:0006836 neurotransmitter transport GO:0006837 serotonin transport GO:0007270 neuron-neuron synaptic transmission GO:0007320 insemination GO:0007584 response to nutrient GO:0007611 learning or memory GO:0007613 memory GO:0007618 mating GO:0007620 copulation GO:0007623 circadian rhythm GO:0008015 blood circulation GO:0009636 response to toxic substance GO:0009991 response to extracellular stimulus GO:0010721 negative regulation of cell development GO:0014074 response to purine-containing compound GO:0015844 monoamine transport GO:0015850 organic hydroxy compound transport GO:0021534 cell proliferation in hindbrain GO:0021536 diencephalon development GO:0021794 thalamus development GO:0021924 cell proliferation in external granule layer GO:0021930 cerebellar granule cell precursor proliferation GO:0021936 regulation of cerebellar granule cell precursor proliferation GO:0021941 negative regulation of cerebellar granule cell precursor proliferation GO:0030900 forebrain development GO:0030902 hindbrain development GO:0031667 response to nutrient levels GO:0032225 regulation of synaptic transmission, dopaminergic GO:0032227 negative regulation of synaptic transmission, dopaminergic GO:0032355 response to estradiol GO:0032526 response to retinoic acid GO:0035150 regulation of tube size GO:0035176 social behavior GO:0035265 organ growth GO:0036293 response to decreased oxygen levels GO:0042310 vasoconstriction GO:0042493 response to drug GO:0042713 sperm ejaculation GO:0044706 multi-multicellular organism process GO:0044708 single-organism behavior GO:0045665 negative regulation of neuron differentiation GO:0045787 positive regulation of cell cycle GO:0045926 negative regulation of growth GO:0046620 regulation of organ growth GO:0046621 negative regulation of organ growth GO:0046683 response to organophosphorus GO:0048511 rhythmic process GO:0048638 regulation of developmental growth GO:0048640 negative regulation of developmental growth GO:0048854 brain morphogenesis GO:0050768 negative regulation of neurogenesis GO:0050804 modulation of synaptic transmission GO:0050805 negative regulation of synaptic transmission GO:0050880 regulation of blood vessel size GO:0050890 cognition GO:0051259 protein oligomerization GO:0051260 protein homooligomerization GO:0051610 serotonin uptake GO:0051703 intraspecies interaction between organisms GO:0051705 multi-organism behavior GO:0051961 negative regulation of nervous system development GO:0061351 neural precursor cell proliferation GO:0070305 response to cGMP GO:0070482 response to oxygen levels GO:0071229 cellular response to acid chemical GO:0071300 cellular response to retinoic acid GO:0071321 cellular response to cGMP GO:0071396 cellular response to lipid GO:0071407 cellular response to organic cyclic compound GO:0071417 cellular response to organonitrogen compound GO:0090066 regulation of anatomical structure size GO:0098657 import into cell GO:0098810 neurotransmitter reuptake GO:2000177 regulation of neural precursor cell proliferation GO:2000178 negative regulation of neural precursor cell proliferation |
Molecular Function |
GO:0000149 SNARE binding GO:0003779 actin binding GO:0005326 neurotransmitter transporter activity GO:0005328 neurotransmitter:sodium symporter activity GO:0005335 serotonin:sodium symporter activity GO:0008144 drug binding GO:0008504 monoamine transmembrane transporter activity GO:0015077 monovalent inorganic cation transmembrane transporter activity GO:0015081 sodium ion transmembrane transporter activity GO:0015222 serotonin transmembrane transporter activity GO:0015291 secondary active transmembrane transporter activity GO:0015293 symporter activity GO:0015294 solute:cation symporter activity GO:0015370 solute:sodium symporter activity GO:0017016 Ras GTPase binding GO:0017022 myosin binding GO:0017075 syntaxin-1 binding GO:0017137 Rab GTPase binding GO:0019811 cocaine binding GO:0019905 syntaxin binding GO:0022804 active transmembrane transporter activity GO:0031267 small GTPase binding GO:0046873 metal ion transmembrane transporter activity GO:0050998 nitric-oxide synthase binding GO:0051015 actin filament binding GO:0051020 GTPase binding GO:1901618 organic hydroxy compound transmembrane transporter activity |
Cellular Component |
GO:0010008 endosome membrane GO:0044440 endosomal part GO:0045121 membrane raft GO:0098589 membrane region GO:0098793 presynapse GO:0098857 membrane microdomain |
KEGG |
hsa04726 Serotonergic synapse |
Reactome |
R-HSA-112316: Neuronal System R-HSA-112311: Neurotransmitter Clearance In The Synaptic Cleft R-HSA-380615: Serotonin clearance from the synaptic cleft R-HSA-112315: Transmission across Chemical Synapses |
Summary | |
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Symbol | SLC6A4 |
Name | solute carrier family 6 (neurotransmitter transporter), member 4 |
Aliases | 5-HTT; SERT1; serotonin transporter 1; OCD1; solute carrier family 6 (neurotransmitter transporter, serotoni ...... |
Chromosomal Location | 17q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between SLC6A4 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | SLC6A4 |
Name | solute carrier family 6 (neurotransmitter transporter), member 4 |
Aliases | 5-HTT; SERT1; serotonin transporter 1; OCD1; solute carrier family 6 (neurotransmitter transporter, serotoni ...... |
Chromosomal Location | 17q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of SLC6A4 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | SLC6A4 |
Name | solute carrier family 6 (neurotransmitter transporter), member 4 |
Aliases | 5-HTT; SERT1; serotonin transporter 1; OCD1; solute carrier family 6 (neurotransmitter transporter, serotoni ...... |
Chromosomal Location | 17q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of SLC6A4 in various data sets.
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Points in the above scatter plot represent the mutation difference of SLC6A4 in various data sets.
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Summary | |
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Symbol | SLC6A4 |
Name | solute carrier family 6 (neurotransmitter transporter), member 4 |
Aliases | 5-HTT; SERT1; serotonin transporter 1; OCD1; solute carrier family 6 (neurotransmitter transporter, serotoni ...... |
Chromosomal Location | 17q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SLC6A4. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | SLC6A4 |
Name | solute carrier family 6 (neurotransmitter transporter), member 4 |
Aliases | 5-HTT; SERT1; serotonin transporter 1; OCD1; solute carrier family 6 (neurotransmitter transporter, serotoni ...... |
Chromosomal Location | 17q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SLC6A4. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SLC6A4. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | SLC6A4 |
Name | solute carrier family 6 (neurotransmitter transporter), member 4 |
Aliases | 5-HTT; SERT1; serotonin transporter 1; OCD1; solute carrier family 6 (neurotransmitter transporter, serotoni ...... |
Chromosomal Location | 17q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SLC6A4. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | SLC6A4 |
Name | solute carrier family 6 (neurotransmitter transporter), member 4 |
Aliases | 5-HTT; SERT1; serotonin transporter 1; OCD1; solute carrier family 6 (neurotransmitter transporter, serotoni ...... |
Chromosomal Location | 17q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of SLC6A4 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | SLC6A4 |
Name | solute carrier family 6 (neurotransmitter transporter), member 4 |
Aliases | 5-HTT; SERT1; serotonin transporter 1; OCD1; solute carrier family 6 (neurotransmitter transporter, serotoni ...... |
Chromosomal Location | 17q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between SLC6A4 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | SLC6A4 |
Name | solute carrier family 6 (neurotransmitter transporter), member 4 |
Aliases | 5-HTT; SERT1; serotonin transporter 1; OCD1; solute carrier family 6 (neurotransmitter transporter, serotoni ...... |
Chromosomal Location | 17q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting SLC6A4 collected from DrugBank database. |
Details on drugs targeting SLC6A4.
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