TISIDB

Summary
Symbol	SLC6A9
Name	solute carrier family 6 (neurotransmitter transporter, glycine), member 9
Aliases	glyT-1; solute carrier family 6 member 9; Sodium- and chloride-dependent glycine transporter 1
Chromosomal Location	1p33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Membrane; Multi-pass membrane protein.
Domain	PF00209 Sodium
Function	Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals. May play a role in regulation of glycine levels in NMDA receptor-mediated neurotransmission.

> Gene Ontology [ TOP ]
Biological Process	GO:0001505 regulation of neurotransmitter levels GO:0003333 amino acid transmembrane transport GO:0006820 anion transport GO:0006836 neurotransmitter transport GO:0006865 amino acid transport GO:0007269 neurotransmitter secretion GO:0007270 neuron-neuron synaptic transmission GO:0015711 organic anion transport GO:0015804 neutral amino acid transport GO:0015816 glycine transport GO:0015849 organic acid transport GO:0023061 signal release GO:0036233 glycine import GO:0043090 amino acid import GO:0043092 L-amino acid import GO:0046717 acid secretion GO:0046942 carboxylic acid transport GO:0060012 synaptic transmission, glycinergic GO:0061536 glycine secretion GO:0061537 glycine secretion, neurotransmission GO:0099531 presynaptic process involved in chemical synaptic transmission GO:0099643 signal release from synapse GO:1903825 organic acid transmembrane transport GO:1905039 carboxylic acid transmembrane transport
Molecular Function	GO:0005283 sodium:amino acid symporter activity GO:0005294 neutral L-amino acid secondary active transmembrane transporter activity GO:0005326 neurotransmitter transporter activity GO:0005328 neurotransmitter:sodium symporter activity GO:0005342 organic acid transmembrane transporter activity GO:0005343 organic acid:sodium symporter activity GO:0005416 cation:amino acid symporter activity GO:0015077 monovalent inorganic cation transmembrane transporter activity GO:0015081 sodium ion transmembrane transporter activity GO:0015171 amino acid transmembrane transporter activity GO:0015175 neutral amino acid transmembrane transporter activity GO:0015179 L-amino acid transmembrane transporter activity GO:0015187 glycine transmembrane transporter activity GO:0015291 secondary active transmembrane transporter activity GO:0015293 symporter activity GO:0015294 solute:cation symporter activity GO:0015370 solute:sodium symporter activity GO:0015375 glycine:sodium symporter activity GO:0022804 active transmembrane transporter activity GO:0046873 metal ion transmembrane transporter activity GO:0046943 carboxylic acid transmembrane transporter activity
Cellular Component	GO:0098793 presynapse

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-425428: Amine compound SLC transporters R-HSA-442660: Na+/Cl- dependent neurotransmitter transporters R-HSA-425407: SLC-mediated transmembrane transport R-HSA-382551: Transmembrane transport of small molecules R-HSA-425366: Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds

Summary
Symbol	SLC6A9
Name	solute carrier family 6 (neurotransmitter transporter, glycine), member 9
Aliases	glyT-1; solute carrier family 6 member 9; Sodium- and chloride-dependent glycine transporter 1
Chromosomal Location	1p33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between SLC6A9 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining [ TOP ]
There is no record.

Summary
Symbol	SLC6A9
Name	solute carrier family 6 (neurotransmitter transporter, glycine), member 9
Aliases	glyT-1; solute carrier family 6 member 9; Sodium- and chloride-dependent glycine transporter 1
Chromosomal Location	1p33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

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Statistical results of SLC6A9 in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	SLC6A9
Name	solute carrier family 6 (neurotransmitter transporter, glycine), member 9
Aliases	glyT-1; solute carrier family 6 member 9; Sodium- and chloride-dependent glycine transporter 1
Chromosomal Location	1p33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

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Points in the above scatter plot represent the expression difference of SLC6A9 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	-0.862	0.0456
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	-1.604	0.113
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	-0.31	0.665
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	-0.125	0.775
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0.126	0.94
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	-0.44	0.838
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	0.241	0.57
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	-0.017	0.982
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	0.425	0.643
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	0.776	0.337
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	1.308	0.219
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	0.01	0.945

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of SLC6A9 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	0	0	0	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	0	0	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	3.7	2.7	1	1
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	7.1	-7.1	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	3.7	1.7	2	0.532
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	4.8	0	4.8	1
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	0	0	0	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	7.7	0	7.7	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	11.1	6.2	4.9	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	11.1	-11.1	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	25	0	25	0.364
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	5.3	0	5.3	0.507
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	4.5	0	4.5	1
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	6.2	0	6.2	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	0	1

Summary
Symbol	SLC6A9
Name	solute carrier family 6 (neurotransmitter transporter, glycine), member 9
Aliases	glyT-1; solute carrier family 6 member 9; Sodium- and chloride-dependent glycine transporter 1
Chromosomal Location	1p33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SLC6A9. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	SLC6A9
Name	solute carrier family 6 (neurotransmitter transporter, glycine), member 9
Aliases	glyT-1; solute carrier family 6 member 9; Sodium- and chloride-dependent glycine transporter 1
Chromosomal Location	1p33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SLC6A9. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SLC6A9. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	SLC6A9
Name	solute carrier family 6 (neurotransmitter transporter, glycine), member 9
Aliases	glyT-1; solute carrier family 6 member 9; Sodium- and chloride-dependent glycine transporter 1
Chromosomal Location	1p33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SLC6A9. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	SLC6A9
Name	solute carrier family 6 (neurotransmitter transporter, glycine), member 9
Aliases	glyT-1; solute carrier family 6 member 9; Sodium- and chloride-dependent glycine transporter 1
Chromosomal Location	1p33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of SLC6A9 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	SLC6A9
Name	solute carrier family 6 (neurotransmitter transporter, glycine), member 9
Aliases	glyT-1; solute carrier family 6 member 9; Sodium- and chloride-dependent glycine transporter 1
Chromosomal Location	1p33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between SLC6A9 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	SLC6A9
Name	solute carrier family 6 (neurotransmitter transporter, glycine), member 9
Aliases	glyT-1; solute carrier family 6 member 9; Sodium- and chloride-dependent glycine transporter 1
Chromosomal Location	1p33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting SLC6A9 collected from DrugBank database.

> Drugs from DrugBank database

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Details on drugs targeting SLC6A9.

ID	Name	Drug Type	Targets	#Targets
DB00145	Glycine	Small Molecule	AGXT, AGXT2, ALAS1, ALAS2, BAAT, GARS, GATM, GCAT, GCSH, GLDC, GLR ......	30

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