Summary | |
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Symbol | SLC7A11 |
Name | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 |
Aliases | xCT; CCBR1; amino acid transport system xc-; calcium channel blocker resistance protein CCBR1; solute carrie ...... |
Chromosomal Location | 4q28.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Membrane Multi-pass membrane protein |
Domain |
PF13520 Amino acid permease |
Function |
Sodium-independent, high-affinity exchange of anionic amino acids with high specificity for anionic form of cystine and glutamate. |
Biological Process |
GO:0001654 eye development GO:0002088 lens development in camera-type eye GO:0003333 amino acid transmembrane transport GO:0006820 anion transport GO:0006835 dicarboxylic acid transport GO:0006865 amino acid transport GO:0006979 response to oxidative stress GO:0007423 sensory organ development GO:0007596 blood coagulation GO:0007599 hemostasis GO:0009636 response to toxic substance GO:0015711 organic anion transport GO:0015800 acidic amino acid transport GO:0015807 L-amino acid transport GO:0015813 L-glutamate transport GO:0015849 organic acid transport GO:0030168 platelet activation GO:0034109 homotypic cell-cell adhesion GO:0035094 response to nicotine GO:0043010 camera-type eye development GO:0043279 response to alkaloid GO:0046942 carboxylic acid transport GO:0050817 coagulation GO:0050878 regulation of body fluid levels GO:0050900 leukocyte migration GO:0070306 lens fiber cell differentiation GO:0070527 platelet aggregation GO:0089711 L-glutamate transmembrane transport GO:0098656 anion transmembrane transport GO:1903825 organic acid transmembrane transport GO:1905039 carboxylic acid transmembrane transport |
Molecular Function |
GO:0000099 sulfur amino acid transmembrane transporter activity GO:0005294 neutral L-amino acid secondary active transmembrane transporter activity GO:0005313 L-glutamate transmembrane transporter activity GO:0005342 organic acid transmembrane transporter activity GO:0008509 anion transmembrane transporter activity GO:0008514 organic anion transmembrane transporter activity GO:0015171 amino acid transmembrane transporter activity GO:0015172 acidic amino acid transmembrane transporter activity GO:0015175 neutral amino acid transmembrane transporter activity GO:0015291 secondary active transmembrane transporter activity GO:0015297 antiporter activity GO:0015327 cystine:glutamate antiporter activity GO:0015328 cystine secondary active transmembrane transporter activity GO:0022804 active transmembrane transporter activity GO:0046943 carboxylic acid transmembrane transporter activity GO:0072349 modified amino acid transmembrane transporter activity GO:1901680 sulfur-containing amino acid secondary active transmembrane transporter activity GO:1901682 sulfur compound transmembrane transporter activity |
Cellular Component |
GO:0005791 rough endoplasmic reticulum |
KEGG | - |
Reactome |
R-HSA-425374: Amino acid and oligopeptide SLC transporters R-HSA-352230: Amino acid transport across the plasma membrane R-HSA-210991: Basigin interactions R-HSA-202733: Cell surface interactions at the vascular wall R-HSA-109582: Hemostasis R-HSA-425407: SLC-mediated transmembrane transport R-HSA-382551: Transmembrane transport of small molecules R-HSA-425393: Transport of inorganic cations/anions and amino acids/oligopeptides |
Summary | |
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Symbol | SLC7A11 |
Name | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 |
Aliases | xCT; CCBR1; amino acid transport system xc-; calcium channel blocker resistance protein CCBR1; solute carrie ...... |
Chromosomal Location | 4q28.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between SLC7A11 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | SLC7A11 |
Name | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 |
Aliases | xCT; CCBR1; amino acid transport system xc-; calcium channel blocker resistance protein CCBR1; solute carrie ...... |
Chromosomal Location | 4q28.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of SLC7A11 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | SLC7A11 |
Name | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 |
Aliases | xCT; CCBR1; amino acid transport system xc-; calcium channel blocker resistance protein CCBR1; solute carrie ...... |
Chromosomal Location | 4q28.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of SLC7A11 in various data sets.
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Points in the above scatter plot represent the mutation difference of SLC7A11 in various data sets.
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Summary | |
---|---|
Symbol | SLC7A11 |
Name | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 |
Aliases | xCT; CCBR1; amino acid transport system xc-; calcium channel blocker resistance protein CCBR1; solute carrie ...... |
Chromosomal Location | 4q28.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SLC7A11. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | SLC7A11 |
Name | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 |
Aliases | xCT; CCBR1; amino acid transport system xc-; calcium channel blocker resistance protein CCBR1; solute carrie ...... |
Chromosomal Location | 4q28.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SLC7A11. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SLC7A11. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | SLC7A11 |
Name | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 |
Aliases | xCT; CCBR1; amino acid transport system xc-; calcium channel blocker resistance protein CCBR1; solute carrie ...... |
Chromosomal Location | 4q28.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SLC7A11. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | SLC7A11 |
Name | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 |
Aliases | xCT; CCBR1; amino acid transport system xc-; calcium channel blocker resistance protein CCBR1; solute carrie ...... |
Chromosomal Location | 4q28.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of SLC7A11 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | SLC7A11 |
Name | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 |
Aliases | xCT; CCBR1; amino acid transport system xc-; calcium channel blocker resistance protein CCBR1; solute carrie ...... |
Chromosomal Location | 4q28.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between SLC7A11 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | SLC7A11 |
Name | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 |
Aliases | xCT; CCBR1; amino acid transport system xc-; calcium channel blocker resistance protein CCBR1; solute carrie ...... |
Chromosomal Location | 4q28.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting SLC7A11 collected from DrugBank database. |
Details on drugs targeting SLC7A11.
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