Summary | |
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Symbol | SLITRK3 |
Name | SLIT and NTRK-like family, member 3 |
Aliases | KIAA0848; slit and trk like gene 3; SLIT and NTRK-like protein 3 |
Chromosomal Location | 3q26.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Membrane Single-pass type I membrane protein |
Domain |
PF13855 Leucine rich repeat |
Function |
Suppresses neurite outgrowth. |
Biological Process |
GO:0007409 axonogenesis GO:0007416 synapse assembly GO:0044089 positive regulation of cellular component biogenesis GO:0048667 cell morphogenesis involved in neuron differentiation GO:0050803 regulation of synapse structure or activity GO:0050807 regulation of synapse organization GO:0050808 synapse organization GO:0051962 positive regulation of nervous system development GO:0051963 regulation of synapse assembly GO:0051965 positive regulation of synapse assembly GO:0061564 axon development |
Molecular Function | - |
Cellular Component | - |
KEGG | - |
Reactome | - |
Summary | |
---|---|
Symbol | SLITRK3 |
Name | SLIT and NTRK-like family, member 3 |
Aliases | KIAA0848; slit and trk like gene 3; SLIT and NTRK-like protein 3 |
Chromosomal Location | 3q26.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between SLITRK3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | SLITRK3 |
Name | SLIT and NTRK-like family, member 3 |
Aliases | KIAA0848; slit and trk like gene 3; SLIT and NTRK-like protein 3 |
Chromosomal Location | 3q26.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of SLITRK3 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | SLITRK3 |
Name | SLIT and NTRK-like family, member 3 |
Aliases | KIAA0848; slit and trk like gene 3; SLIT and NTRK-like protein 3 |
Chromosomal Location | 3q26.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of SLITRK3 in various data sets.
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Points in the above scatter plot represent the mutation difference of SLITRK3 in various data sets.
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Summary | |
---|---|
Symbol | SLITRK3 |
Name | SLIT and NTRK-like family, member 3 |
Aliases | KIAA0848; slit and trk like gene 3; SLIT and NTRK-like protein 3 |
Chromosomal Location | 3q26.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SLITRK3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | SLITRK3 |
Name | SLIT and NTRK-like family, member 3 |
Aliases | KIAA0848; slit and trk like gene 3; SLIT and NTRK-like protein 3 |
Chromosomal Location | 3q26.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SLITRK3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SLITRK3. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | SLITRK3 |
Name | SLIT and NTRK-like family, member 3 |
Aliases | KIAA0848; slit and trk like gene 3; SLIT and NTRK-like protein 3 |
Chromosomal Location | 3q26.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SLITRK3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | SLITRK3 |
Name | SLIT and NTRK-like family, member 3 |
Aliases | KIAA0848; slit and trk like gene 3; SLIT and NTRK-like protein 3 |
Chromosomal Location | 3q26.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of SLITRK3 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | SLITRK3 |
Name | SLIT and NTRK-like family, member 3 |
Aliases | KIAA0848; slit and trk like gene 3; SLIT and NTRK-like protein 3 |
Chromosomal Location | 3q26.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between SLITRK3 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | SLITRK3 |
Name | SLIT and NTRK-like family, member 3 |
Aliases | KIAA0848; slit and trk like gene 3; SLIT and NTRK-like protein 3 |
Chromosomal Location | 3q26.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting SLITRK3 collected from DrugBank database. |
There is no record. |