Browse SMAD3

Summary
SymbolSMAD3
NameSMAD family member 3
Aliases JV15-2; HsT17436; MADH3; MAD, mothers against decapentaplegic homolog 3 (Drosophila); SMAD, mothers against ......
Chromosomal Location15q21-q22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasm Nucleus Note=Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 (PubMed:15799969). Through the action of the phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 (PubMed:16751101, PubMed:19289081). Co-localizes with LEMD3 at the nucleus inner membrane (PubMed:15601644). MAPK-mediated phosphorylation appears to have no effect on nuclear import (PubMed:19218245). PDPK1 prevents its nuclear translocation in response to TGF-beta (PubMed:17327236).
Domain PF03165 MH1 domain
PF03166 MH2 domain
Function

Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.

> Gene Ontology
 
Biological Process GO:0001501 skeletal system development
GO:0001503 ossification
GO:0001558 regulation of cell growth
GO:0001649 osteoblast differentiation
GO:0001654 eye development
GO:0001655 urogenital system development
GO:0001657 ureteric bud development
GO:0001666 response to hypoxia
GO:0001701 in utero embryonic development
GO:0001704 formation of primary germ layer
GO:0001707 mesoderm formation
GO:0001756 somitogenesis
GO:0001819 positive regulation of cytokine production
GO:0001822 kidney development
GO:0001823 mesonephros development
GO:0001837 epithelial to mesenchymal transition
GO:0001889 liver development
GO:0001947 heart looping
GO:0001952 regulation of cell-matrix adhesion
GO:0001954 positive regulation of cell-matrix adhesion
GO:0002062 chondrocyte differentiation
GO:0002076 osteoblast development
GO:0002088 lens development in camera-type eye
GO:0003002 regionalization
GO:0003007 heart morphogenesis
GO:0003143 embryonic heart tube morphogenesis
GO:0006417 regulation of translation
GO:0006606 protein import into nucleus
GO:0006809 nitric oxide biosynthetic process
GO:0006874 cellular calcium ion homeostasis
GO:0006875 cellular metal ion homeostasis
GO:0006913 nucleocytoplasmic transport
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007015 actin filament organization
GO:0007044 cell-substrate junction assembly
GO:0007045 cell-substrate adherens junction assembly
GO:0007050 cell cycle arrest
GO:0007159 leukocyte cell-cell adhesion
GO:0007160 cell-matrix adhesion
GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007183 SMAD protein complex assembly
GO:0007346 regulation of mitotic cell cycle
GO:0007368 determination of left/right symmetry
GO:0007369 gastrulation
GO:0007389 pattern specification process
GO:0007423 sensory organ development
GO:0007440 foregut morphogenesis
GO:0007492 endoderm development
GO:0007498 mesoderm development
GO:0007507 heart development
GO:0007517 muscle organ development
GO:0009799 specification of symmetry
GO:0009855 determination of bilateral symmetry
GO:0009880 embryonic pattern specification
GO:0009894 regulation of catabolic process
GO:0009895 negative regulation of catabolic process
GO:0009952 anterior/posterior pattern specification
GO:0010608 posttranscriptional regulation of gene expression
GO:0010692 regulation of alkaline phosphatase activity
GO:0010694 positive regulation of alkaline phosphatase activity
GO:0010717 regulation of epithelial to mesenchymal transition
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0010810 regulation of cell-substrate adhesion
GO:0010811 positive regulation of cell-substrate adhesion
GO:0010921 regulation of phosphatase activity
GO:0010922 positive regulation of phosphatase activity
GO:0010950 positive regulation of endopeptidase activity
GO:0010952 positive regulation of peptidase activity
GO:0014706 striated muscle tissue development
GO:0016049 cell growth
GO:0016055 Wnt signaling pathway
GO:0016202 regulation of striated muscle tissue development
GO:0016311 dephosphorylation
GO:0016441 posttranscriptional gene silencing
GO:0016458 gene silencing
GO:0017015 regulation of transforming growth factor beta receptor signaling pathway
GO:0017038 protein import
GO:0017148 negative regulation of translation
GO:0019048 modulation by virus of host morphology or physiology
GO:0019049 evasion or tolerance of host defenses by virus
GO:0023019 signal transduction involved in regulation of gene expression
GO:0030038 contractile actin filament bundle assembly
GO:0030198 extracellular matrix organization
GO:0030278 regulation of ossification
GO:0030279 negative regulation of ossification
GO:0030282 bone mineralization
GO:0030308 negative regulation of cell growth
GO:0030335 positive regulation of cell migration
GO:0030500 regulation of bone mineralization
GO:0030501 positive regulation of bone mineralization
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030878 thyroid gland development
GO:0031032 actomyosin structure organization
GO:0031047 gene silencing by RNA
GO:0031050 dsRNA fragmentation
GO:0031053 primary miRNA processing
GO:0031214 biomineral tissue development
GO:0031348 negative regulation of defense response
GO:0031589 cell-substrate adhesion
GO:0031647 regulation of protein stability
GO:0032102 negative regulation of response to external stimulus
GO:0032103 positive regulation of response to external stimulus
GO:0032231 regulation of actin filament bundle assembly
GO:0032233 positive regulation of actin filament bundle assembly
GO:0032330 regulation of chondrocyte differentiation
GO:0032332 positive regulation of chondrocyte differentiation
GO:0032386 regulation of intracellular transport
GO:0032388 positive regulation of intracellular transport
GO:0032611 interleukin-1 beta production
GO:0032612 interleukin-1 production
GO:0032651 regulation of interleukin-1 beta production
GO:0032652 regulation of interleukin-1 production
GO:0032731 positive regulation of interleukin-1 beta production
GO:0032732 positive regulation of interleukin-1 production
GO:0032906 transforming growth factor beta2 production
GO:0032907 transforming growth factor beta3 production
GO:0032909 regulation of transforming growth factor beta2 production
GO:0032910 regulation of transforming growth factor beta3 production
GO:0032916 positive regulation of transforming growth factor beta3 production
GO:0032924 activin receptor signaling pathway
GO:0032956 regulation of actin cytoskeleton organization
GO:0032970 regulation of actin filament-based process
GO:0033157 regulation of intracellular protein transport
GO:0033687 osteoblast proliferation
GO:0033688 regulation of osteoblast proliferation
GO:0033689 negative regulation of osteoblast proliferation
GO:0034248 regulation of cellular amide metabolic process
GO:0034249 negative regulation of cellular amide metabolic process
GO:0034329 cell junction assembly
GO:0034330 cell junction organization
GO:0034332 adherens junction organization
GO:0034333 adherens junction assembly
GO:0034470 ncRNA processing
GO:0034504 protein localization to nucleus
GO:0035050 embryonic heart tube development
GO:0035194 posttranscriptional gene silencing by RNA
GO:0035195 gene silencing by miRNA
GO:0035196 production of miRNAs involved in gene silencing by miRNA
GO:0035239 tube morphogenesis
GO:0035270 endocrine system development
GO:0035282 segmentation
GO:0035303 regulation of dephosphorylation
GO:0035306 positive regulation of dephosphorylation
GO:0035411 catenin import into nucleus
GO:0035412 regulation of catenin import into nucleus
GO:0035413 positive regulation of catenin import into nucleus
GO:0035821 modification of morphology or physiology of other organism
GO:0036293 response to decreased oxygen levels
GO:0038092 nodal signaling pathway
GO:0040017 positive regulation of locomotion
GO:0040029 regulation of gene expression, epigenetic
GO:0042110 T cell activation
GO:0042176 regulation of protein catabolic process
GO:0042177 negative regulation of protein catabolic process
GO:0042306 regulation of protein import into nucleus
GO:0042307 positive regulation of protein import into nucleus
GO:0042990 regulation of transcription factor import into nucleus
GO:0042991 transcription factor import into nucleus
GO:0042993 positive regulation of transcription factor import into nucleus
GO:0043010 camera-type eye development
GO:0043062 extracellular structure organization
GO:0043149 stress fiber assembly
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043331 response to dsRNA
GO:0044003 modification by symbiont of host morphology or physiology
GO:0044089 positive regulation of cellular component biogenesis
GO:0044413 avoidance of host defenses
GO:0044415 evasion or tolerance of host defenses
GO:0044744 protein targeting to nucleus
GO:0045216 cell-cell junction organization
GO:0045428 regulation of nitric oxide biosynthetic process
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0045444 fat cell differentiation
GO:0045598 regulation of fat cell differentiation
GO:0045599 negative regulation of fat cell differentiation
GO:0045667 regulation of osteoblast differentiation
GO:0045668 negative regulation of osteoblast differentiation
GO:0045778 positive regulation of ossification
GO:0045785 positive regulation of cell adhesion
GO:0045786 negative regulation of cell cycle
GO:0045862 positive regulation of proteolysis
GO:0045926 negative regulation of growth
GO:0045930 negative regulation of mitotic cell cycle
GO:0046209 nitric oxide metabolic process
GO:0046822 regulation of nucleocytoplasmic transport
GO:0046824 positive regulation of nucleocytoplasmic transport
GO:0048041 focal adhesion assembly
GO:0048332 mesoderm morphogenesis
GO:0048339 paraxial mesoderm development
GO:0048340 paraxial mesoderm morphogenesis
GO:0048546 digestive tract morphogenesis
GO:0048562 embryonic organ morphogenesis
GO:0048565 digestive tract development
GO:0048568 embryonic organ development
GO:0048617 embryonic foregut morphogenesis
GO:0048634 regulation of muscle organ development
GO:0048701 embryonic cranial skeleton morphogenesis
GO:0048704 embryonic skeletal system morphogenesis
GO:0048705 skeletal system morphogenesis
GO:0048706 embryonic skeletal system development
GO:0048732 gland development
GO:0048762 mesenchymal cell differentiation
GO:0050673 epithelial cell proliferation
GO:0050678 regulation of epithelial cell proliferation
GO:0050727 regulation of inflammatory response
GO:0050728 negative regulation of inflammatory response
GO:0050821 protein stabilization
GO:0050918 positive chemotaxis
GO:0050920 regulation of chemotaxis
GO:0050921 positive regulation of chemotaxis
GO:0050926 regulation of positive chemotaxis
GO:0050927 positive regulation of positive chemotaxis
GO:0051017 actin filament bundle assembly
GO:0051098 regulation of binding
GO:0051169 nuclear transport
GO:0051170 nuclear import
GO:0051216 cartilage development
GO:0051222 positive regulation of protein transport
GO:0051272 positive regulation of cellular component movement
GO:0051480 regulation of cytosolic calcium ion concentration
GO:0051481 negative regulation of cytosolic calcium ion concentration
GO:0051492 regulation of stress fiber assembly
GO:0051493 regulation of cytoskeleton organization
GO:0051495 positive regulation of cytoskeleton organization
GO:0051496 positive regulation of stress fiber assembly
GO:0051701 interaction with host
GO:0051817 modification of morphology or physiology of other organism involved in symbiotic interaction
GO:0051832 avoidance of defenses of other organism involved in symbiotic interaction
GO:0051834 evasion or tolerance of defenses of other organism involved in symbiotic interaction
GO:0051893 regulation of focal adhesion assembly
GO:0051894 positive regulation of focal adhesion assembly
GO:0052173 response to defenses of other organism involved in symbiotic interaction
GO:0052200 response to host defenses
GO:0052547 regulation of peptidase activity
GO:0052548 regulation of endopeptidase activity
GO:0055074 calcium ion homeostasis
GO:0055123 digestive system development
GO:0060039 pericardium development
GO:0060070 canonical Wnt signaling pathway
GO:0060290 transdifferentiation
GO:0060395 SMAD protein signal transduction
GO:0060485 mesenchyme development
GO:0060537 muscle tissue development
GO:0060562 epithelial tube morphogenesis
GO:0061008 hepaticobiliary system development
GO:0061035 regulation of cartilage development
GO:0061036 positive regulation of cartilage development
GO:0061041 regulation of wound healing
GO:0061045 negative regulation of wound healing
GO:0061053 somite development
GO:0061371 determination of heart left/right asymmetry
GO:0061448 connective tissue development
GO:0061572 actin filament bundle organization
GO:0061614 pri-miRNA transcription from RNA polymerase II promoter
GO:0070167 regulation of biomineral tissue development
GO:0070169 positive regulation of biomineral tissue development
GO:0070306 lens fiber cell differentiation
GO:0070482 response to oxygen levels
GO:0070486 leukocyte aggregation
GO:0070489 T cell aggregation
GO:0070918 production of small RNA involved in gene silencing by RNA
GO:0071359 cellular response to dsRNA
GO:0071407 cellular response to organic cyclic compound
GO:0071559 response to transforming growth factor beta
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:0071593 lymphocyte aggregation
GO:0071604 transforming growth factor beta production
GO:0071634 regulation of transforming growth factor beta production
GO:0071636 positive regulation of transforming growth factor beta production
GO:0072001 renal system development
GO:0072073 kidney epithelium development
GO:0072132 mesenchyme morphogenesis
GO:0072163 mesonephric epithelium development
GO:0072164 mesonephric tubule development
GO:0072503 cellular divalent inorganic cation homeostasis
GO:0072507 divalent inorganic cation homeostasis
GO:0072593 reactive oxygen species metabolic process
GO:0075136 response to host
GO:0085029 extracellular matrix assembly
GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0090101 negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0090109 regulation of cell-substrate junction assembly
GO:0090287 regulation of cellular response to growth factor stimulus
GO:0090288 negative regulation of cellular response to growth factor stimulus
GO:0090316 positive regulation of intracellular protein transport
GO:0097191 extrinsic apoptotic signaling pathway
GO:0097296 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:0198738 cell-cell signaling by wnt
GO:1900180 regulation of protein localization to nucleus
GO:1900182 positive regulation of protein localization to nucleus
GO:1901201 regulation of extracellular matrix assembly
GO:1901203 positive regulation of extracellular matrix assembly
GO:1901861 regulation of muscle tissue development
GO:1901888 regulation of cell junction assembly
GO:1901890 positive regulation of cell junction assembly
GO:1902593 single-organism nuclear import
GO:1902893 regulation of pri-miRNA transcription from RNA polymerase II promoter
GO:1902895 positive regulation of pri-miRNA transcription from RNA polymerase II promoter
GO:1903034 regulation of response to wounding
GO:1903035 negative regulation of response to wounding
GO:1903053 regulation of extracellular matrix organization
GO:1903055 positive regulation of extracellular matrix organization
GO:1903391 regulation of adherens junction organization
GO:1903393 positive regulation of adherens junction organization
GO:1903409 reactive oxygen species biosynthetic process
GO:1903426 regulation of reactive oxygen species biosynthetic process
GO:1903428 positive regulation of reactive oxygen species biosynthetic process
GO:1903533 regulation of protein targeting
GO:1903829 positive regulation of cellular protein localization
GO:1903844 regulation of cellular response to transforming growth factor beta stimulus
GO:1903845 negative regulation of cellular response to transforming growth factor beta stimulus
GO:1904407 positive regulation of nitric oxide metabolic process
GO:1904589 regulation of protein import
GO:1904591 positive regulation of protein import
GO:1904888 cranial skeletal system development
GO:1904951 positive regulation of establishment of protein localization
GO:2000116 regulation of cysteine-type endopeptidase activity
GO:2000147 positive regulation of cell motility
GO:2000377 regulation of reactive oxygen species metabolic process
GO:2000379 positive regulation of reactive oxygen species metabolic process
GO:2001056 positive regulation of cysteine-type endopeptidase activity
GO:2001057 reactive nitrogen species metabolic process
GO:2001233 regulation of apoptotic signaling pathway
GO:2001235 positive regulation of apoptotic signaling pathway
GO:2001267 regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
Molecular Function GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific
GO:0000987 core promoter proximal region sequence-specific DNA binding
GO:0001085 RNA polymerase II transcription factor binding
GO:0001102 RNA polymerase II activating transcription factor binding
GO:0001159 core promoter proximal region DNA binding
GO:0003682 chromatin binding
GO:0005057 receptor signaling protein activity
GO:0005072 transforming growth factor beta receptor, cytoplasmic mediator activity
GO:0005126 cytokine receptor binding
GO:0005160 transforming growth factor beta receptor binding
GO:0005518 collagen binding
GO:0008013 beta-catenin binding
GO:0008134 transcription factor binding
GO:0019902 phosphatase binding
GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity
GO:0031490 chromatin DNA binding
GO:0031625 ubiquitin protein ligase binding
GO:0032182 ubiquitin-like protein binding
GO:0033613 activating transcription factor binding
GO:0035326 enhancer binding
GO:0043130 ubiquitin binding
GO:0043425 bHLH transcription factor binding
GO:0043566 structure-specific DNA binding
GO:0044389 ubiquitin-like protein ligase binding
GO:0046332 SMAD binding
GO:0046982 protein heterodimerization activity
GO:0070410 co-SMAD binding
GO:0070412 R-SMAD binding
Cellular Component GO:0000785 chromatin
GO:0000790 nuclear chromatin
GO:0005635 nuclear envelope
GO:0005637 nuclear inner membrane
GO:0005667 transcription factor complex
GO:0031965 nuclear membrane
GO:0043235 receptor complex
GO:0044454 nuclear chromosome part
GO:0071141 SMAD protein complex
GO:0071144 SMAD2-SMAD3 protein complex
> KEGG and Reactome Pathway
 
KEGG hsa04068 FoxO signaling pathway
hsa04110 Cell cycle
hsa04144 Endocytosis
hsa04310 Wnt signaling pathway
hsa04350 TGF-beta signaling pathway
hsa04390 Hippo signaling pathway
hsa04520 Adherens junction
hsa04550 Signaling pathways regulating pluripotency of stem cells
Reactome R-HSA-5688426: Deubiquitination
R-HSA-1266738: Developmental Biology
R-HSA-1643685: Disease
R-HSA-5663202: Diseases of signal transduction
R-HSA-2173795: Downregulation of SMAD2/3
R-HSA-2173788: Downregulation of TGF-beta receptor signaling
R-HSA-74160: Gene Expression
R-HSA-212436: Generic Transcription Pathway
R-HSA-3304349: Loss of Function of SMAD2/3 in Cancer
R-HSA-3304347: Loss of Function of SMAD4 in Cancer
R-HSA-3656534: Loss of Function of TGFBR1 in Cancer
R-HSA-392499: Metabolism of proteins
R-HSA-597592: Post-translational protein modification
R-HSA-3315487: SMAD2/3 MH2 Domain Mutants in Cancer
R-HSA-3304356: SMAD2/3 Phosphorylation Motif Mutants in Cancer
R-HSA-2173796: SMAD2/SMAD3
R-HSA-3311021: SMAD4 MH2 Domain Mutants in Cancer
R-HSA-162582: Signal Transduction
R-HSA-1502540: Signaling by Activin
R-HSA-1181150: Signaling by NODAL
R-HSA-170834: Signaling by TGF-beta Receptor Complex
R-HSA-3304351: Signaling by TGF-beta Receptor Complex in Cancer
R-HSA-2173789: TGF-beta receptor signaling activates SMADs
R-HSA-3656532: TGFBR1 KD Mutants in Cancer
R-HSA-2173793: Transcriptional activity of SMAD2/SMAD3
R-HSA-5689880: Ub-specific processing proteases
Summary
SymbolSMAD3
NameSMAD family member 3
Aliases JV15-2; HsT17436; MADH3; MAD, mothers against decapentaplegic homolog 3 (Drosophila); SMAD, mothers against ......
Chromosomal Location15q21-q22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between SMAD3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between SMAD3 and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
21159663MelanomaInhibit immunityInduction of monocyte chemoattractant protein-1 and interleukin-10 by TGFbeta1 in melanoma enhances tumor infiltration and immunosuppression. Supernatants from TGFβ1-treated A375 cells enhanced MCP-1-dependent migration of monocytes, which, in turn, expressed high levels of TGF,β1, bFGF, and VEGF mRNA. Moreover, these supernatants also inhibited functional properties of dendritic cells through IL-10-dependent mechanisms. When using in vitro, the TGFβ1-blocking peptide P144, TGFβ1-dependent Smad3 phosphorylation, and expression of MCP-1 and IL-10 were inhibited.
29606356hepatocellular carcinomaPromote immunityTransforming growth factor β (TGF-β) and Smad3 activation are important in Ter-cell generation.
25238097ovarian carcinomaPromote immunityMechanistically, Foxp1 interacted with the transcription factors Smad2 and Smad3 in preactivated CD8(+) T cells in response to microenvironmental transforming growth factor-beta (TGF-beta), and was essential for its suppressive activity. Therefore, Smad2 and Smad3-mediated c-Myc repression requires Foxp1 expression in T cells. Furthermore, Foxp1 directly mediated TGF-beta-induced c-Jun transcriptional repression, which abrogated T cell activity.
Summary
SymbolSMAD3
NameSMAD family member 3
Aliases JV15-2; HsT17436; MADH3; MAD, mothers against decapentaplegic homolog 3 (Drosophila); SMAD, mothers against ......
Chromosomal Location15q21-q22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of SMAD3 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolSMAD3
NameSMAD family member 3
Aliases JV15-2; HsT17436; MADH3; MAD, mothers against decapentaplegic homolog 3 (Drosophila); SMAD, mothers against ......
Chromosomal Location15q21-q22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of SMAD3 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.1170.645
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.2390.86
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.0280.978
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.0030.994
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.2150.926
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.260.926
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.1860.618
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.3140.84
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.0480.978
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.2710.825
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.3570.842
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.2470.0662
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of SMAD3 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277311.1011.10.0181
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275911.1011.10.0286
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.804.81
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.5012.51
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91606.2-6.21
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59011.1-11.11
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.611.1-8.50.299
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.57.7-3.21
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1614014.3-14.30.209
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolSMAD3
NameSMAD family member 3
Aliases JV15-2; HsT17436; MADH3; MAD, mothers against decapentaplegic homolog 3 (Drosophila); SMAD, mothers against ......
Chromosomal Location15q21-q22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SMAD3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolSMAD3
NameSMAD family member 3
Aliases JV15-2; HsT17436; MADH3; MAD, mothers against decapentaplegic homolog 3 (Drosophila); SMAD, mothers against ......
Chromosomal Location15q21-q22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SMAD3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SMAD3.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolSMAD3
NameSMAD family member 3
Aliases JV15-2; HsT17436; MADH3; MAD, mothers against decapentaplegic homolog 3 (Drosophila); SMAD, mothers against ......
Chromosomal Location15q21-q22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SMAD3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolSMAD3
NameSMAD family member 3
Aliases JV15-2; HsT17436; MADH3; MAD, mothers against decapentaplegic homolog 3 (Drosophila); SMAD, mothers against ......
Chromosomal Location15q21-q22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of SMAD3 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolSMAD3
NameSMAD family member 3
Aliases JV15-2; HsT17436; MADH3; MAD, mothers against decapentaplegic homolog 3 (Drosophila); SMAD, mothers against ......
Chromosomal Location15q21-q22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between SMAD3 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolSMAD3
NameSMAD family member 3
Aliases JV15-2; HsT17436; MADH3; MAD, mothers against decapentaplegic homolog 3 (Drosophila); SMAD, mothers against ......
Chromosomal Location15q21-q22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting SMAD3 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.