TISIDB

Summary
Symbol	SMC1B
Name	structural maintenance of chromosomes 1B
Aliases	bK268H5; SMC1L2; SMC1 structural maintenance of chromosomes 1-like 2 (yeast); SMC1BETA; SMC protein 1B; SMC1 ......
Chromosomal Location	22q13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Nucleus Chromosome Chromosome, centromere Note=Associates with chromatin. In prophase I stage of meiosis, localizes along the AE of synaptonemal complexes. In late-pachytene-diplotene, the bulk of protein dissociates from the chromosome arms probably because of phosphorylation by PLK, except at centromeres, where cohesin complexes remain. Remains chromatin associated at the centromeres up to metaphase II. At anaphase II, dissociates from centromeres, allowing chromosomes segregation (By similarity).
Domain	PF06470 SMC proteins Flexible Hinge Domain PF02463 RecF/RecN/SMC N terminal domain
Function	Meiosis-specific component of cohesin complex. Required for the maintenance of meiotic cohesion, but not, or only to a minor extent, for its establishment. Contributes to axial element (AE) formation and the organization of chromatin loops along the AE. Plays a key role in synapsis, recombination and chromosome movements. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The meiosis-specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I (By similarity).

> Gene Ontology [ TOP ]
Biological Process	GO:0000819 sister chromatid segregation GO:0007059 chromosome segregation GO:0007062 sister chromatid cohesion GO:0007126 meiotic nuclear division GO:0051321 meiotic cell cycle GO:0098813 nuclear chromosome segregation GO:1903046 meiotic cell cycle process
Molecular Function	-
Cellular Component	GO:0000775 chromosome, centromeric region GO:0000793 condensed chromosome GO:0000794 condensed nuclear chromosome GO:0000795 synaptonemal complex GO:0000798 nuclear cohesin complex GO:0000800 lateral element GO:0008278 cohesin complex GO:0030893 meiotic cohesin complex GO:0034991 nuclear meiotic cohesin complex GO:0044454 nuclear chromosome part GO:0098687 chromosomal region

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa04110 Cell cycle hsa04114 Oocyte meiosis
Reactome	R-HSA-1640170: Cell Cycle R-HSA-1500620: Meiosis R-HSA-1221632: Meiotic synapsis

Summary
Symbol	SMC1B
Name	structural maintenance of chromosomes 1B
Aliases	bK268H5; SMC1L2; SMC1 structural maintenance of chromosomes 1-like 2 (yeast); SMC1BETA; SMC protein 1B; SMC1 ......
Chromosomal Location	22q13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between SMC1B and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining [ TOP ]
There is no record.

Summary
Symbol	SMC1B
Name	structural maintenance of chromosomes 1B
Aliases	bK268H5; SMC1L2; SMC1 structural maintenance of chromosomes 1-like 2 (yeast); SMC1BETA; SMC protein 1B; SMC1 ......
Chromosomal Location	22q13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

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Statistical results of SMC1B in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	SMC1B
Name	structural maintenance of chromosomes 1B
Aliases	bK268H5; SMC1L2; SMC1 structural maintenance of chromosomes 1-like 2 (yeast); SMC1BETA; SMC protein 1B; SMC1 ......
Chromosomal Location	22q13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

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Points in the above scatter plot represent the expression difference of SMC1B in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	-0.144	0.633
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	-0.03	0.958
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	-0.237	0.577
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	-0.816	0.0356
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	-0.716	0.627
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	-0.943	0.606
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	0.494	0.453
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	0.933	0.322
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	0.21	0.835
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	-0.146	0.739
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	-0.268	0.669
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	0.826	0.0107

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of SMC1B in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	7.1	0	7.1	0.452
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	10	0	10	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	0	1.4	-1.4	1
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	0	1.7	-1.7	1
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	19	17.6	1.4	1
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	25	0	25	0.473
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	15.4	27.3	-11.9	0.63
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0	12.5	-12.5	0.52
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	11.1	-11.1	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	14.3	-14.3	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	5.3	3.7	1.6	1
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	4.5	7.7	-3.2	1
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	6.2	0	6.2	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	0	1

Summary
Symbol	SMC1B
Name	structural maintenance of chromosomes 1B
Aliases	bK268H5; SMC1L2; SMC1 structural maintenance of chromosomes 1-like 2 (yeast); SMC1BETA; SMC protein 1B; SMC1 ......
Chromosomal Location	22q13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SMC1B. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	SMC1B
Name	structural maintenance of chromosomes 1B
Aliases	bK268H5; SMC1L2; SMC1 structural maintenance of chromosomes 1-like 2 (yeast); SMC1BETA; SMC protein 1B; SMC1 ......
Chromosomal Location	22q13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SMC1B. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SMC1B. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	SMC1B
Name	structural maintenance of chromosomes 1B
Aliases	bK268H5; SMC1L2; SMC1 structural maintenance of chromosomes 1-like 2 (yeast); SMC1BETA; SMC protein 1B; SMC1 ......
Chromosomal Location	22q13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SMC1B. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	SMC1B
Name	structural maintenance of chromosomes 1B
Aliases	bK268H5; SMC1L2; SMC1 structural maintenance of chromosomes 1-like 2 (yeast); SMC1BETA; SMC protein 1B; SMC1 ......
Chromosomal Location	22q13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of SMC1B expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	SMC1B
Name	structural maintenance of chromosomes 1B
Aliases	bK268H5; SMC1L2; SMC1 structural maintenance of chromosomes 1-like 2 (yeast); SMC1BETA; SMC protein 1B; SMC1 ......
Chromosomal Location	22q13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between SMC1B and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	SMC1B
Name	structural maintenance of chromosomes 1B
Aliases	bK268H5; SMC1L2; SMC1 structural maintenance of chromosomes 1-like 2 (yeast); SMC1BETA; SMC protein 1B; SMC1 ......
Chromosomal Location	22q13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting SMC1B collected from DrugBank database.

> Drugs from DrugBank database [ TOP ]
There is no record.

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