Summary | |
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Symbol | SMC3 |
Name | structural maintenance of chromosomes 3 |
Aliases | SMC3L1; bamacan; bamacan proteoglycan; CSPG6; chondroitin sulfate proteoglycan 6 (bamacan); CDLS3; HCAPL1; S ...... |
Chromosomal Location | 10q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus Chromosome Chromosome, centromere Note=Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK, except at centromeres, where cohesin complexes remain. At anaphase, the RAD21 subunit of the cohesin complex is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation. The phosphorylated form at Ser-1083 is preferentially associated with unsynapsed chromosomal regions (By similarity). |
Domain |
PF06470 SMC proteins Flexible Hinge Domain PF02463 RecF/RecN/SMC N terminal domain |
Function |
Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex plays also an important role in spindle pole assembly during mitosis and in chromosomes movement. |
Biological Process |
GO:0000070 mitotic sister chromatid segregation GO:0000819 sister chromatid segregation GO:0006260 DNA replication GO:0006261 DNA-dependent DNA replication GO:0006275 regulation of DNA replication GO:0007052 mitotic spindle organization GO:0007059 chromosome segregation GO:0007062 sister chromatid cohesion GO:0007064 mitotic sister chromatid cohesion GO:0007067 mitotic nuclear division GO:0007126 meiotic nuclear division GO:0008156 negative regulation of DNA replication GO:0010948 negative regulation of cell cycle process GO:0016925 protein sumoylation GO:0018205 peptidyl-lysine modification GO:0019827 stem cell population maintenance GO:0032875 regulation of DNA endoreduplication GO:0032876 negative regulation of DNA endoreduplication GO:0042023 DNA endoreduplication GO:0044786 cell cycle DNA replication GO:0045786 negative regulation of cell cycle GO:0051052 regulation of DNA metabolic process GO:0051053 negative regulation of DNA metabolic process GO:0051321 meiotic cell cycle GO:0090329 regulation of DNA-dependent DNA replication GO:0098727 maintenance of cell number GO:0098813 nuclear chromosome segregation GO:1903046 meiotic cell cycle process GO:2000104 negative regulation of DNA-dependent DNA replication |
Molecular Function |
GO:0003682 chromatin binding GO:0003774 motor activity GO:0003777 microtubule motor activity GO:0036033 mediator complex binding GO:0045502 dynein binding GO:0046982 protein heterodimerization activity |
Cellular Component |
GO:0000775 chromosome, centromeric region GO:0000785 chromatin GO:0000793 condensed chromosome GO:0000794 condensed nuclear chromosome GO:0000795 synaptonemal complex GO:0000798 nuclear cohesin complex GO:0000800 lateral element GO:0000922 spindle pole GO:0005578 proteinaceous extracellular matrix GO:0005604 basement membrane GO:0005819 spindle GO:0008278 cohesin complex GO:0008280 cohesin core heterodimer GO:0016363 nuclear matrix GO:0030893 meiotic cohesin complex GO:0034399 nuclear periphery GO:0034991 nuclear meiotic cohesin complex GO:0044420 extracellular matrix component GO:0044454 nuclear chromosome part GO:0098687 chromosomal region |
KEGG |
hsa04110 Cell cycle hsa04114 Oocyte meiosis |
Reactome |
R-HSA-1640170: Cell Cycle R-HSA-69278: Cell Cycle, Mitotic R-HSA-2470946: Cohesin Loading onto Chromatin R-HSA-2468052: Establishment of Sister Chromatid Cohesion R-HSA-68886: M Phase R-HSA-1500620: Meiosis R-HSA-1221632: Meiotic synapsis R-HSA-392499: Metabolism of proteins R-HSA-68882: Mitotic Anaphase R-HSA-2555396: Mitotic Metaphase and Anaphase R-HSA-68877: Mitotic Prometaphase R-HSA-68884: Mitotic Telophase/Cytokinesis R-HSA-597592: Post-translational protein modification R-HSA-2500257: Resolution of Sister Chromatid Cohesion R-HSA-69242: S Phase R-HSA-3108232: SUMO E3 ligases SUMOylate target proteins R-HSA-2990846: SUMOylation R-HSA-3108214: SUMOylation of DNA damage response and repair proteins R-HSA-2467813: Separation of Sister Chromatids |
Summary | |
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Symbol | SMC3 |
Name | structural maintenance of chromosomes 3 |
Aliases | SMC3L1; bamacan; bamacan proteoglycan; CSPG6; chondroitin sulfate proteoglycan 6 (bamacan); CDLS3; HCAPL1; S ...... |
Chromosomal Location | 10q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between SMC3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | SMC3 |
Name | structural maintenance of chromosomes 3 |
Aliases | SMC3L1; bamacan; bamacan proteoglycan; CSPG6; chondroitin sulfate proteoglycan 6 (bamacan); CDLS3; HCAPL1; S ...... |
Chromosomal Location | 10q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of SMC3 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | SMC3 |
Name | structural maintenance of chromosomes 3 |
Aliases | SMC3L1; bamacan; bamacan proteoglycan; CSPG6; chondroitin sulfate proteoglycan 6 (bamacan); CDLS3; HCAPL1; S ...... |
Chromosomal Location | 10q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of SMC3 in various data sets.
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Points in the above scatter plot represent the mutation difference of SMC3 in various data sets.
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Summary | |
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Symbol | SMC3 |
Name | structural maintenance of chromosomes 3 |
Aliases | SMC3L1; bamacan; bamacan proteoglycan; CSPG6; chondroitin sulfate proteoglycan 6 (bamacan); CDLS3; HCAPL1; S ...... |
Chromosomal Location | 10q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SMC3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | SMC3 |
Name | structural maintenance of chromosomes 3 |
Aliases | SMC3L1; bamacan; bamacan proteoglycan; CSPG6; chondroitin sulfate proteoglycan 6 (bamacan); CDLS3; HCAPL1; S ...... |
Chromosomal Location | 10q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SMC3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SMC3. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | SMC3 |
Name | structural maintenance of chromosomes 3 |
Aliases | SMC3L1; bamacan; bamacan proteoglycan; CSPG6; chondroitin sulfate proteoglycan 6 (bamacan); CDLS3; HCAPL1; S ...... |
Chromosomal Location | 10q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SMC3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | SMC3 |
Name | structural maintenance of chromosomes 3 |
Aliases | SMC3L1; bamacan; bamacan proteoglycan; CSPG6; chondroitin sulfate proteoglycan 6 (bamacan); CDLS3; HCAPL1; S ...... |
Chromosomal Location | 10q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of SMC3 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | SMC3 |
Name | structural maintenance of chromosomes 3 |
Aliases | SMC3L1; bamacan; bamacan proteoglycan; CSPG6; chondroitin sulfate proteoglycan 6 (bamacan); CDLS3; HCAPL1; S ...... |
Chromosomal Location | 10q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between SMC3 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | SMC3 |
Name | structural maintenance of chromosomes 3 |
Aliases | SMC3L1; bamacan; bamacan proteoglycan; CSPG6; chondroitin sulfate proteoglycan 6 (bamacan); CDLS3; HCAPL1; S ...... |
Chromosomal Location | 10q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting SMC3 collected from DrugBank database. |
There is no record. |