Summary | |
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Symbol | SMOC1 |
Name | SPARC related modular calcium binding 1 |
Aliases | OAS; secreted modular calcium-binding protein 1; SMOC-1; SPARC-related modular calcium-binding protein 1 |
Chromosomal Location | 14q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted, extracellular space, extracellular matrix, basement membrane Note=In or around the basement membrane. |
Domain |
PF07648 Kazal-type serine protease inhibitor domain PF10591 Secreted protein acidic and rich in cysteine Ca binding region PF00086 Thyroglobulin type-1 repeat |
Function |
Plays essential roles in both eye and limb development. Probable regulator of osteoblast differentiation. |
Biological Process |
GO:0001503 ossification GO:0001649 osteoblast differentiation GO:0001654 eye development GO:0007423 sensory organ development GO:0030278 regulation of ossification GO:0045667 regulation of osteoblast differentiation GO:0048736 appendage development GO:0060173 limb development |
Molecular Function | - |
Cellular Component |
GO:0005578 proteinaceous extracellular matrix GO:0005604 basement membrane GO:0044420 extracellular matrix component |
KEGG | - |
Reactome | - |
Summary | |
---|---|
Symbol | SMOC1 |
Name | SPARC related modular calcium binding 1 |
Aliases | OAS; secreted modular calcium-binding protein 1; SMOC-1; SPARC-related modular calcium-binding protein 1 |
Chromosomal Location | 14q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between SMOC1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | SMOC1 |
Name | SPARC related modular calcium binding 1 |
Aliases | OAS; secreted modular calcium-binding protein 1; SMOC-1; SPARC-related modular calcium-binding protein 1 |
Chromosomal Location | 14q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of SMOC1 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | SMOC1 |
Name | SPARC related modular calcium binding 1 |
Aliases | OAS; secreted modular calcium-binding protein 1; SMOC-1; SPARC-related modular calcium-binding protein 1 |
Chromosomal Location | 14q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of SMOC1 in various data sets.
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Points in the above scatter plot represent the mutation difference of SMOC1 in various data sets.
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Summary | |
---|---|
Symbol | SMOC1 |
Name | SPARC related modular calcium binding 1 |
Aliases | OAS; secreted modular calcium-binding protein 1; SMOC-1; SPARC-related modular calcium-binding protein 1 |
Chromosomal Location | 14q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SMOC1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | SMOC1 |
Name | SPARC related modular calcium binding 1 |
Aliases | OAS; secreted modular calcium-binding protein 1; SMOC-1; SPARC-related modular calcium-binding protein 1 |
Chromosomal Location | 14q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SMOC1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SMOC1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | SMOC1 |
Name | SPARC related modular calcium binding 1 |
Aliases | OAS; secreted modular calcium-binding protein 1; SMOC-1; SPARC-related modular calcium-binding protein 1 |
Chromosomal Location | 14q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SMOC1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | SMOC1 |
Name | SPARC related modular calcium binding 1 |
Aliases | OAS; secreted modular calcium-binding protein 1; SMOC-1; SPARC-related modular calcium-binding protein 1 |
Chromosomal Location | 14q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of SMOC1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | SMOC1 |
Name | SPARC related modular calcium binding 1 |
Aliases | OAS; secreted modular calcium-binding protein 1; SMOC-1; SPARC-related modular calcium-binding protein 1 |
Chromosomal Location | 14q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between SMOC1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | SMOC1 |
Name | SPARC related modular calcium binding 1 |
Aliases | OAS; secreted modular calcium-binding protein 1; SMOC-1; SPARC-related modular calcium-binding protein 1 |
Chromosomal Location | 14q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting SMOC1 collected from DrugBank database. |
There is no record. |