Summary | |
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Symbol | SNRPE |
Name | small nuclear ribonucleoprotein polypeptide E |
Aliases | Sm-E; B-raf; HYPT11; SME; sm protein E; snRNP-E; Small nuclear ribonucleoprotein E |
Chromosomal Location | 1q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm, cytosol. Nucleus. Note=SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes. |
Domain |
PF01423 LSM domain |
Function |
Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. As part of the U7 snRNP it is involved in histone 3'-end processing. May indirectly play a role in hair development. |
Biological Process |
GO:0000245 spliceosomal complex assembly GO:0000375 RNA splicing, via transesterification reactions GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile GO:0000387 spliceosomal snRNP assembly GO:0000398 mRNA splicing, via spliceosome GO:0006353 DNA-templated transcription, termination GO:0006369 termination of RNA polymerase II transcription GO:0006397 mRNA processing GO:0006913 nucleocytoplasmic transport GO:0008334 histone mRNA metabolic process GO:0008380 RNA splicing GO:0022613 ribonucleoprotein complex biogenesis GO:0022618 ribonucleoprotein complex assembly GO:0042303 molting cycle GO:0042633 hair cycle GO:0051169 nuclear transport GO:0051170 nuclear import GO:0071826 ribonucleoprotein complex subunit organization |
Molecular Function | - |
Cellular Component |
GO:0005681 spliceosomal complex GO:0005682 U5 snRNP GO:0005683 U7 snRNP GO:0005685 U1 snRNP GO:0005686 U2 snRNP GO:0005687 U4 snRNP GO:0005689 U12-type spliceosomal complex GO:0005697 telomerase holoenzyme complex GO:0030532 small nuclear ribonucleoprotein complex GO:0034708 methyltransferase complex GO:0034709 methylosome GO:0034715 pICln-Sm protein complex GO:0034719 SMN-Sm protein complex GO:0046540 U4/U6 x U5 tri-snRNP complex GO:0071011 precatalytic spliceosome GO:0071013 catalytic step 2 spliceosome GO:0097525 spliceosomal snRNP complex GO:0097526 spliceosomal tri-snRNP complex |
KEGG |
hsa03040 Spliceosome |
Reactome |
R-HSA-109688: Cleavage of Growing Transcript in the Termination Region R-HSA-74160: Gene Expression R-HSA-194441: Metabolism of non-coding RNA R-HSA-112297: Post-Elongation Processing of Intronless pre-mRNA R-HSA-76044: Post-Elongation Processing of the Transcript R-HSA-72203: Processing of Capped Intron-Containing Pre-mRNA R-HSA-75067: Processing of Capped Intronless Pre-mRNA R-HSA-73857: RNA Polymerase II Transcription R-HSA-73856: RNA Polymerase II Transcription Termination R-HSA-77588: SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-111367: SLBP independent Processing of Histone Pre-mRNAs R-HSA-72172: mRNA Splicing R-HSA-72163: mRNA Splicing - Major Pathway R-HSA-72165: mRNA Splicing - Minor Pathway R-HSA-191859: snRNP Assembly |
Summary | |
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Symbol | SNRPE |
Name | small nuclear ribonucleoprotein polypeptide E |
Aliases | Sm-E; B-raf; HYPT11; SME; sm protein E; snRNP-E; Small nuclear ribonucleoprotein E |
Chromosomal Location | 1q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between SNRPE and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | SNRPE |
Name | small nuclear ribonucleoprotein polypeptide E |
Aliases | Sm-E; B-raf; HYPT11; SME; sm protein E; snRNP-E; Small nuclear ribonucleoprotein E |
Chromosomal Location | 1q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of SNRPE in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | SNRPE |
Name | small nuclear ribonucleoprotein polypeptide E |
Aliases | Sm-E; B-raf; HYPT11; SME; sm protein E; snRNP-E; Small nuclear ribonucleoprotein E |
Chromosomal Location | 1q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of SNRPE in various data sets.
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There is no record. |
Summary | |
---|---|
Symbol | SNRPE |
Name | small nuclear ribonucleoprotein polypeptide E |
Aliases | Sm-E; B-raf; HYPT11; SME; sm protein E; snRNP-E; Small nuclear ribonucleoprotein E |
Chromosomal Location | 1q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SNRPE. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | SNRPE |
Name | small nuclear ribonucleoprotein polypeptide E |
Aliases | Sm-E; B-raf; HYPT11; SME; sm protein E; snRNP-E; Small nuclear ribonucleoprotein E |
Chromosomal Location | 1q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SNRPE. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SNRPE. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | SNRPE |
Name | small nuclear ribonucleoprotein polypeptide E |
Aliases | Sm-E; B-raf; HYPT11; SME; sm protein E; snRNP-E; Small nuclear ribonucleoprotein E |
Chromosomal Location | 1q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SNRPE. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | SNRPE |
Name | small nuclear ribonucleoprotein polypeptide E |
Aliases | Sm-E; B-raf; HYPT11; SME; sm protein E; snRNP-E; Small nuclear ribonucleoprotein E |
Chromosomal Location | 1q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of SNRPE expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | SNRPE |
Name | small nuclear ribonucleoprotein polypeptide E |
Aliases | Sm-E; B-raf; HYPT11; SME; sm protein E; snRNP-E; Small nuclear ribonucleoprotein E |
Chromosomal Location | 1q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between SNRPE and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | SNRPE |
Name | small nuclear ribonucleoprotein polypeptide E |
Aliases | Sm-E; B-raf; HYPT11; SME; sm protein E; snRNP-E; Small nuclear ribonucleoprotein E |
Chromosomal Location | 1q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting SNRPE collected from DrugBank database. |
There is no record. |