TISIDB

Summary
Symbol	SOAT1
Name	sterol O-acyltransferase 1
Aliases	acyl-Coenzyme A: cholesterol acyltransferase; STAT; sterol O-acyltransferase (acyl-Coenzyme A: cholesterol a ......
Chromosomal Location	1q25
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Endoplasmic reticulum membrane Multi-pass membrane protein
Domain	PF03062 MBOAT
Function	Catalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol. Plays a role in lipoprotein assembly and dietary cholesterol absorption. In addition to its acyltransferase activity, it may act as a ligase.

> Gene Ontology [ TOP ]
Biological Process	GO:0006066 alcohol metabolic process GO:0006869 lipid transport GO:0008202 steroid metabolic process GO:0008203 cholesterol metabolic process GO:0009100 glycoprotein metabolic process GO:0009101 glycoprotein biosynthetic process GO:0010559 regulation of glycoprotein biosynthetic process GO:0010560 positive regulation of glycoprotein biosynthetic process GO:0010742 macrophage derived foam cell differentiation GO:0010876 lipid localization GO:0010878 cholesterol storage GO:0015850 organic hydroxy compound transport GO:0015918 sterol transport GO:0016125 sterol metabolic process GO:0019915 lipid storage GO:0030258 lipid modification GO:0030301 cholesterol transport GO:0033344 cholesterol efflux GO:0034377 plasma lipoprotein particle assembly GO:0034379 very-low-density lipoprotein particle assembly GO:0034433 steroid esterification GO:0034434 sterol esterification GO:0034435 cholesterol esterification GO:0042632 cholesterol homeostasis GO:0042982 amyloid precursor protein metabolic process GO:0042983 amyloid precursor protein biosynthetic process GO:0042984 regulation of amyloid precursor protein biosynthetic process GO:0042986 positive regulation of amyloid precursor protein biosynthetic process GO:0051235 maintenance of location GO:0055088 lipid homeostasis GO:0055092 sterol homeostasis GO:0065005 protein-lipid complex assembly GO:0071825 protein-lipid complex subunit organization GO:0071827 plasma lipoprotein particle organization GO:0090077 foam cell differentiation GO:0097006 regulation of plasma lipoprotein particle levels GO:1901615 organic hydroxy compound metabolic process GO:1902652 secondary alcohol metabolic process GO:1903018 regulation of glycoprotein metabolic process GO:1903020 positive regulation of glycoprotein metabolic process
Molecular Function	GO:0000062 fatty-acyl-CoA binding GO:0004772 sterol O-acyltransferase activity GO:0005496 steroid binding GO:0008374 O-acyltransferase activity GO:0015485 cholesterol binding GO:0016746 transferase activity, transferring acyl groups GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GO:0032934 sterol binding GO:0034736 cholesterol O-acyltransferase activity GO:0043178 alcohol binding GO:0048037 cofactor binding GO:0050662 coenzyme binding GO:1901681 sulfur compound binding
Cellular Component	-

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa00100 Steroid biosynthesis
Reactome	R-HSA-171052: LDL-mediated lipid transport R-HSA-73923: Lipid digestion, mobilization, and transport R-HSA-174824: Lipoprotein metabolism R-HSA-1430728: Metabolism R-HSA-556833: Metabolism of lipids and lipoproteins

Summary
Symbol	SOAT1
Name	sterol O-acyltransferase 1
Aliases	acyl-Coenzyme A: cholesterol acyltransferase; STAT; sterol O-acyltransferase (acyl-Coenzyme A: cholesterol a ......
Chromosomal Location	1q25
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between SOAT1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining

[ TOP ]

Literatures describing the relation between SOAT1 and anti-tumor immunity in human cancer.

PMID	Cancer type	Relation to immunity	Evidence sentences
24879823	melanoma	Promote immunity	These immunogenic effects include modulation of STAT signaling; induction of an immunogenic type of cancer cell death through exposure of calreticulin and release of ATP and high-mobility group protein box-1 (HMGB-1); and enhancement of the effector immune response through modulation of programmed death receptor 1-ligand and mannose-6-phosphate receptor expression.
29872580	Melanoma	Promote immunity; Essential for immunotherapy	Amplification of JAK/STAT signaling in tumor cells through genetic inhibition of the negative regulator PTPN2 potentiated IFN-γ response in vitro and in vivo, and may be a target to enhance immunotherapy efficacy.

Summary
Symbol	SOAT1
Name	sterol O-acyltransferase 1
Aliases	acyl-Coenzyme A: cholesterol acyltransferase; STAT; sterol O-acyltransferase (acyl-Coenzyme A: cholesterol a ......
Chromosomal Location	1q25
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

[ TOP ]

Statistical results of SOAT1 in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	SOAT1
Name	sterol O-acyltransferase 1
Aliases	acyl-Coenzyme A: cholesterol acyltransferase; STAT; sterol O-acyltransferase (acyl-Coenzyme A: cholesterol a ......
Chromosomal Location	1q25
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

[ TOP ]

Points in the above scatter plot represent the expression difference of SOAT1 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	-0.641	0.0453
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	-0.193	0.918
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	-0.97	0.492
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0.033	0.914
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	-0.066	0.969
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0.166	0.943
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	0.111	0.809
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	-0.241	0.9
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	0.506	0.812
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	0.69	0.665
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	1.232	0.607
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	0.134	0.153

> Mutation difference between responders and non-responders

[ TOP ]

Points in the above scatter plot represent the mutation difference of SOAT1 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	0	0	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	0	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	3.7	3.7	0.27
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	3.7	3.7	0.314
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	0	0	1
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	0	0	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	0	0	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	11.1	11.1	0.36
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	0	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	25	25	0.364
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	0	0	1
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	0	0	1
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	0	0	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	1

Summary
Symbol	SOAT1
Name	sterol O-acyltransferase 1
Aliases	acyl-Coenzyme A: cholesterol acyltransferase; STAT; sterol O-acyltransferase (acyl-Coenzyme A: cholesterol a ......
Chromosomal Location	1q25
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SOAT1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	SOAT1
Name	sterol O-acyltransferase 1
Aliases	acyl-Coenzyme A: cholesterol acyltransferase; STAT; sterol O-acyltransferase (acyl-Coenzyme A: cholesterol a ......
Chromosomal Location	1q25
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SOAT1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SOAT1. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	SOAT1
Name	sterol O-acyltransferase 1
Aliases	acyl-Coenzyme A: cholesterol acyltransferase; STAT; sterol O-acyltransferase (acyl-Coenzyme A: cholesterol a ......
Chromosomal Location	1q25
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SOAT1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	SOAT1
Name	sterol O-acyltransferase 1
Aliases	acyl-Coenzyme A: cholesterol acyltransferase; STAT; sterol O-acyltransferase (acyl-Coenzyme A: cholesterol a ......
Chromosomal Location	1q25
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of SOAT1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	SOAT1
Name	sterol O-acyltransferase 1
Aliases	acyl-Coenzyme A: cholesterol acyltransferase; STAT; sterol O-acyltransferase (acyl-Coenzyme A: cholesterol a ......
Chromosomal Location	1q25
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between SOAT1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	SOAT1
Name	sterol O-acyltransferase 1
Aliases	acyl-Coenzyme A: cholesterol acyltransferase; STAT; sterol O-acyltransferase (acyl-Coenzyme A: cholesterol a ......
Chromosomal Location	1q25
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting SOAT1 collected from DrugBank database.

> Drugs from DrugBank database

[ TOP ]

Details on drugs targeting SOAT1.

ID	Name	Drug Type	Targets	#Targets
DB00973	Ezetimibe	Small Molecule	ANPEP, NPC1L1, SOAT1	3
DB01094	Hesperetin	Small Molecule	MTTP, SHBG, SOAT1, SOAT2	4

Browse SOAT1