Summary | |
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Symbol | SOD2 |
Name | superoxide dismutase 2, mitochondrial |
Aliases | MNSOD; MVCD6; Mn superoxide dismutase; indophenoloxidase B; manganese-containing superoxide dismutase; manga ...... |
Chromosomal Location | 6q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Mitochondrion matrix. |
Domain |
PF02777 Iron/manganese superoxide dismutases PF00081 Iron/manganese superoxide dismutases |
Function |
Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. |
Biological Process |
GO:0000302 response to reactive oxygen species GO:0000303 response to superoxide GO:0000305 response to oxygen radical GO:0001306 age-dependent response to oxidative stress GO:0001315 age-dependent response to reactive oxygen species GO:0001836 release of cytochrome c from mitochondria GO:0001976 neurological system process involved in regulation of systemic arterial blood pressure GO:0003013 circulatory system process GO:0003018 vascular process in circulatory system GO:0003044 regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003068 regulation of systemic arterial blood pressure by acetylcholine GO:0003069 vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure GO:0003070 regulation of systemic arterial blood pressure by neurotransmitter GO:0003073 regulation of systemic arterial blood pressure GO:0003085 negative regulation of systemic arterial blood pressure GO:0006801 superoxide metabolic process GO:0006979 response to oxidative stress GO:0007568 aging GO:0007571 age-dependent general metabolic decline GO:0008015 blood circulation GO:0008217 regulation of blood pressure GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008637 apoptotic mitochondrial changes GO:0009636 response to toxic substance GO:0010035 response to inorganic substance GO:0019430 removal of superoxide radicals GO:0032364 oxygen homeostasis GO:0033483 gas homeostasis GO:0034599 cellular response to oxidative stress GO:0034614 cellular response to reactive oxygen species GO:0035150 regulation of tube size GO:0036473 cell death in response to oxidative stress GO:0042311 vasodilation GO:0043523 regulation of neuron apoptotic process GO:0043524 negative regulation of neuron apoptotic process GO:0045776 negative regulation of blood pressure GO:0050880 regulation of blood vessel size GO:0051259 protein oligomerization GO:0051260 protein homooligomerization GO:0051262 protein tetramerization GO:0051289 protein homotetramerization GO:0051402 neuron apoptotic process GO:0070997 neuron death GO:0071450 cellular response to oxygen radical GO:0071451 cellular response to superoxide GO:0072593 reactive oxygen species metabolic process GO:0090066 regulation of anatomical structure size GO:0097193 intrinsic apoptotic signaling pathway GO:0098754 detoxification GO:0098869 cellular oxidant detoxification GO:1900407 regulation of cellular response to oxidative stress GO:1900408 negative regulation of cellular response to oxidative stress GO:1901214 regulation of neuron death GO:1901215 negative regulation of neuron death GO:1902175 regulation of oxidative stress-induced intrinsic apoptotic signaling pathway GO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway GO:1902532 negative regulation of intracellular signal transduction GO:1902882 regulation of response to oxidative stress GO:1902883 negative regulation of response to oxidative stress GO:1903201 regulation of oxidative stress-induced cell death GO:1903202 negative regulation of oxidative stress-induced cell death GO:1990748 cellular detoxification GO:2001233 regulation of apoptotic signaling pathway GO:2001234 negative regulation of apoptotic signaling pathway GO:2001242 regulation of intrinsic apoptotic signaling pathway GO:2001243 negative regulation of intrinsic apoptotic signaling pathway |
Molecular Function |
GO:0004784 superoxide dismutase activity GO:0016209 antioxidant activity GO:0016721 oxidoreductase activity, acting on superoxide radicals as acceptor GO:0030145 manganese ion binding |
Cellular Component |
GO:0005759 mitochondrial matrix |
KEGG |
hsa04068 FoxO signaling pathway hsa04146 Peroxisome |
Reactome |
R-HSA-2262752: Cellular responses to stress R-HSA-8862803: Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-3299685: Detoxification of Reactive Oxygen Species R-HSA-1643685: Disease R-HSA-8863678: Neurodegenerative Diseases |
Summary | |
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Symbol | SOD2 |
Name | superoxide dismutase 2, mitochondrial |
Aliases | MNSOD; MVCD6; Mn superoxide dismutase; indophenoloxidase B; manganese-containing superoxide dismutase; manga ...... |
Chromosomal Location | 6q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between SOD2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | SOD2 |
Name | superoxide dismutase 2, mitochondrial |
Aliases | MNSOD; MVCD6; Mn superoxide dismutase; indophenoloxidase B; manganese-containing superoxide dismutase; manga ...... |
Chromosomal Location | 6q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of SOD2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | SOD2 |
Name | superoxide dismutase 2, mitochondrial |
Aliases | MNSOD; MVCD6; Mn superoxide dismutase; indophenoloxidase B; manganese-containing superoxide dismutase; manga ...... |
Chromosomal Location | 6q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of SOD2 in various data sets.
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Points in the above scatter plot represent the mutation difference of SOD2 in various data sets.
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Summary | |
---|---|
Symbol | SOD2 |
Name | superoxide dismutase 2, mitochondrial |
Aliases | MNSOD; MVCD6; Mn superoxide dismutase; indophenoloxidase B; manganese-containing superoxide dismutase; manga ...... |
Chromosomal Location | 6q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SOD2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | SOD2 |
Name | superoxide dismutase 2, mitochondrial |
Aliases | MNSOD; MVCD6; Mn superoxide dismutase; indophenoloxidase B; manganese-containing superoxide dismutase; manga ...... |
Chromosomal Location | 6q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SOD2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SOD2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | SOD2 |
Name | superoxide dismutase 2, mitochondrial |
Aliases | MNSOD; MVCD6; Mn superoxide dismutase; indophenoloxidase B; manganese-containing superoxide dismutase; manga ...... |
Chromosomal Location | 6q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SOD2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | SOD2 |
Name | superoxide dismutase 2, mitochondrial |
Aliases | MNSOD; MVCD6; Mn superoxide dismutase; indophenoloxidase B; manganese-containing superoxide dismutase; manga ...... |
Chromosomal Location | 6q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of SOD2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | SOD2 |
Name | superoxide dismutase 2, mitochondrial |
Aliases | MNSOD; MVCD6; Mn superoxide dismutase; indophenoloxidase B; manganese-containing superoxide dismutase; manga ...... |
Chromosomal Location | 6q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between SOD2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | SOD2 |
Name | superoxide dismutase 2, mitochondrial |
Aliases | MNSOD; MVCD6; Mn superoxide dismutase; indophenoloxidase B; manganese-containing superoxide dismutase; manga ...... |
Chromosomal Location | 6q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting SOD2 collected from DrugBank database. |
Details on drugs targeting SOD2.
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