Summary | |
---|---|
Symbol | SOD3 |
Name | superoxide dismutase 3, extracellular |
Aliases | EC-SOD; Extracellular superoxide dismutase [Cu-Zn] |
Chromosomal Location | 4p15.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted, extracellular space. Note=99% of EC-SOD is anchored to heparan sulfate proteoglycans in the tissue interstitium, and 1% is located in the vasculature in equilibrium between the plasma and the endothelium. |
Domain |
PF00080 Copper/zinc superoxide dismutase (SODC) |
Function |
Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxide radicals into hydrogen peroxide and oxygen. |
Biological Process |
GO:0000302 response to reactive oxygen species GO:0000303 response to superoxide GO:0000305 response to oxygen radical GO:0001666 response to hypoxia GO:0006801 superoxide metabolic process GO:0006979 response to oxidative stress GO:0009636 response to toxic substance GO:0010035 response to inorganic substance GO:0010038 response to metal ion GO:0019430 removal of superoxide radicals GO:0034599 cellular response to oxidative stress GO:0034614 cellular response to reactive oxygen species GO:0036293 response to decreased oxygen levels GO:0046688 response to copper ion GO:0070482 response to oxygen levels GO:0071450 cellular response to oxygen radical GO:0071451 cellular response to superoxide GO:0072593 reactive oxygen species metabolic process GO:0098754 detoxification GO:0098869 cellular oxidant detoxification GO:1990267 response to transition metal nanoparticle GO:1990748 cellular detoxification |
Molecular Function |
GO:0004784 superoxide dismutase activity GO:0005507 copper ion binding GO:0005539 glycosaminoglycan binding GO:0008201 heparin binding GO:0016209 antioxidant activity GO:0016721 oxidoreductase activity, acting on superoxide radicals as acceptor GO:1901681 sulfur compound binding |
Cellular Component |
GO:0005796 Golgi lumen GO:0005802 trans-Golgi network GO:0031984 organelle subcompartment GO:0098791 Golgi subcompartment |
KEGG | - |
Reactome |
R-HSA-2262752: Cellular responses to stress R-HSA-3299685: Detoxification of Reactive Oxygen Species |
Summary | |
---|---|
Symbol | SOD3 |
Name | superoxide dismutase 3, extracellular |
Aliases | EC-SOD; Extracellular superoxide dismutase [Cu-Zn] |
Chromosomal Location | 4p15.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between SOD3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | SOD3 |
Name | superoxide dismutase 3, extracellular |
Aliases | EC-SOD; Extracellular superoxide dismutase [Cu-Zn] |
Chromosomal Location | 4p15.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of SOD3 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | SOD3 |
Name | superoxide dismutase 3, extracellular |
Aliases | EC-SOD; Extracellular superoxide dismutase [Cu-Zn] |
Chromosomal Location | 4p15.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of SOD3 in various data sets.
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Points in the above scatter plot represent the mutation difference of SOD3 in various data sets.
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Summary | |
---|---|
Symbol | SOD3 |
Name | superoxide dismutase 3, extracellular |
Aliases | EC-SOD; Extracellular superoxide dismutase [Cu-Zn] |
Chromosomal Location | 4p15.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SOD3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | SOD3 |
Name | superoxide dismutase 3, extracellular |
Aliases | EC-SOD; Extracellular superoxide dismutase [Cu-Zn] |
Chromosomal Location | 4p15.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SOD3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SOD3. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | SOD3 |
Name | superoxide dismutase 3, extracellular |
Aliases | EC-SOD; Extracellular superoxide dismutase [Cu-Zn] |
Chromosomal Location | 4p15.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SOD3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | SOD3 |
Name | superoxide dismutase 3, extracellular |
Aliases | EC-SOD; Extracellular superoxide dismutase [Cu-Zn] |
Chromosomal Location | 4p15.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of SOD3 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | SOD3 |
Name | superoxide dismutase 3, extracellular |
Aliases | EC-SOD; Extracellular superoxide dismutase [Cu-Zn] |
Chromosomal Location | 4p15.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between SOD3 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |