Browse SOD3

Summary
SymbolSOD3
Namesuperoxide dismutase 3, extracellular
Aliases EC-SOD; Extracellular superoxide dismutase [Cu-Zn]
Chromosomal Location4p15.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Secreted, extracellular space. Note=99% of EC-SOD is anchored to heparan sulfate proteoglycans in the tissue interstitium, and 1% is located in the vasculature in equilibrium between the plasma and the endothelium.
Domain PF00080 Copper/zinc superoxide dismutase (SODC)
Function

Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxide radicals into hydrogen peroxide and oxygen.

> Gene Ontology
 
Biological Process GO:0000302 response to reactive oxygen species
GO:0000303 response to superoxide
GO:0000305 response to oxygen radical
GO:0001666 response to hypoxia
GO:0006801 superoxide metabolic process
GO:0006979 response to oxidative stress
GO:0009636 response to toxic substance
GO:0010035 response to inorganic substance
GO:0010038 response to metal ion
GO:0019430 removal of superoxide radicals
GO:0034599 cellular response to oxidative stress
GO:0034614 cellular response to reactive oxygen species
GO:0036293 response to decreased oxygen levels
GO:0046688 response to copper ion
GO:0070482 response to oxygen levels
GO:0071450 cellular response to oxygen radical
GO:0071451 cellular response to superoxide
GO:0072593 reactive oxygen species metabolic process
GO:0098754 detoxification
GO:0098869 cellular oxidant detoxification
GO:1990267 response to transition metal nanoparticle
GO:1990748 cellular detoxification
Molecular Function GO:0004784 superoxide dismutase activity
GO:0005507 copper ion binding
GO:0005539 glycosaminoglycan binding
GO:0008201 heparin binding
GO:0016209 antioxidant activity
GO:0016721 oxidoreductase activity, acting on superoxide radicals as acceptor
GO:1901681 sulfur compound binding
Cellular Component GO:0005796 Golgi lumen
GO:0005802 trans-Golgi network
GO:0031984 organelle subcompartment
GO:0098791 Golgi subcompartment
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-2262752: Cellular responses to stress
R-HSA-3299685: Detoxification of Reactive Oxygen Species
Summary
SymbolSOD3
Namesuperoxide dismutase 3, extracellular
Aliases EC-SOD; Extracellular superoxide dismutase [Cu-Zn]
Chromosomal Location4p15.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between SOD3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolSOD3
Namesuperoxide dismutase 3, extracellular
Aliases EC-SOD; Extracellular superoxide dismutase [Cu-Zn]
Chromosomal Location4p15.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of SOD3 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolSOD3
Namesuperoxide dismutase 3, extracellular
Aliases EC-SOD; Extracellular superoxide dismutase [Cu-Zn]
Chromosomal Location4p15.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of SOD3 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-1.6350.0554
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-2.7960.29
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.7620.656
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.210.783
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.0740.971
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.5620.814
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.4440.386
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.5180.623
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.3830.741
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 481.7040.261
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.6030.47
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.7120.000598
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of SOD3 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277301.4-1.41
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275901.7-1.71
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.1011.10.36
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47250250.364
1329033130MelanomaallAnti-PD-1 (nivolumab) 382703.7-3.70.415
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 221307.7-7.70.371
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolSOD3
Namesuperoxide dismutase 3, extracellular
Aliases EC-SOD; Extracellular superoxide dismutase [Cu-Zn]
Chromosomal Location4p15.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SOD3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolSOD3
Namesuperoxide dismutase 3, extracellular
Aliases EC-SOD; Extracellular superoxide dismutase [Cu-Zn]
Chromosomal Location4p15.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SOD3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SOD3.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolSOD3
Namesuperoxide dismutase 3, extracellular
Aliases EC-SOD; Extracellular superoxide dismutase [Cu-Zn]
Chromosomal Location4p15.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SOD3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolSOD3
Namesuperoxide dismutase 3, extracellular
Aliases EC-SOD; Extracellular superoxide dismutase [Cu-Zn]
Chromosomal Location4p15.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of SOD3 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolSOD3
Namesuperoxide dismutase 3, extracellular
Aliases EC-SOD; Extracellular superoxide dismutase [Cu-Zn]
Chromosomal Location4p15.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between SOD3 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolSOD3
Namesuperoxide dismutase 3, extracellular
Aliases EC-SOD; Extracellular superoxide dismutase [Cu-Zn]
Chromosomal Location4p15.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting SOD3 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.