Summary | |
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Symbol | SORD |
Name | sorbitol dehydrogenase |
Aliases | HEL-S-95n1; L-iditol 2-dehydrogenase; epididymis secretory sperm binding protein Li 95n |
Chromosomal Location | 15q15-q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Mitochondrion membrane Peripheral membrane protein Cell projection, cilium, flagellum Note=Associated with mitochondria of the midpiece and near the plasma membrane in the principal piece of the flagellum. Also found in the epididymosome, secreted by the epididymal epithelium and that transfers proteins from the epididymal fluid to the sperm surface. |
Domain |
PF08240 Alcohol dehydrogenase GroES-like domain PF00107 Zinc-binding dehydrogenase |
Function |
Converts sorbitol to fructose. Part of the polyol pathway that plays an important role in sperm physiology. May play a role in the sperm motility by providing an energetic source for sperm. |
Biological Process |
GO:0005996 monosaccharide metabolic process GO:0006000 fructose metabolic process GO:0006006 glucose metabolic process GO:0006059 hexitol metabolic process GO:0006060 sorbitol metabolic process GO:0006062 sorbitol catabolic process GO:0006063 uronic acid metabolic process GO:0006064 glucuronate catabolic process GO:0006066 alcohol metabolic process GO:0006970 response to osmotic stress GO:0009991 response to extracellular stimulus GO:0010035 response to inorganic substance GO:0010038 response to metal ion GO:0016051 carbohydrate biosynthetic process GO:0016052 carbohydrate catabolic process GO:0016054 organic acid catabolic process GO:0019318 hexose metabolic process GO:0019319 hexose biosynthetic process GO:0019400 alditol metabolic process GO:0019405 alditol catabolic process GO:0019407 hexitol catabolic process GO:0019519 pentitol metabolic process GO:0019527 pentitol catabolic process GO:0019585 glucuronate metabolic process GO:0019640 glucuronate catabolic process to xylulose 5-phosphate GO:0019751 polyol metabolic process GO:0030317 flagellated sperm motility GO:0031667 response to nutrient levels GO:0042493 response to drug GO:0044262 cellular carbohydrate metabolic process GO:0044275 cellular carbohydrate catabolic process GO:0044282 small molecule catabolic process GO:0044283 small molecule biosynthetic process GO:0044723 single-organism carbohydrate metabolic process GO:0044724 single-organism carbohydrate catabolic process GO:0046164 alcohol catabolic process GO:0046174 polyol catabolic process GO:0046364 monosaccharide biosynthetic process GO:0046370 fructose biosynthetic process GO:0046395 carboxylic acid catabolic process GO:0046686 response to cadmium ion GO:0046688 response to copper ion GO:0051160 L-xylitol catabolic process GO:0051164 L-xylitol metabolic process GO:0051167 xylulose 5-phosphate metabolic process GO:0072329 monocarboxylic acid catabolic process GO:0097722 sperm motility GO:1901159 xylulose 5-phosphate biosynthetic process GO:1901615 organic hydroxy compound metabolic process GO:1901616 organic hydroxy compound catabolic process GO:1990267 response to transition metal nanoparticle |
Molecular Function |
GO:0003939 L-iditol 2-dehydrogenase activity GO:0016614 oxidoreductase activity, acting on CH-OH group of donors GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0030246 carbohydrate binding GO:0031320 hexitol dehydrogenase activity GO:0046526 D-xylulose reductase activity GO:0048037 cofactor binding GO:0050662 coenzyme binding GO:0051287 NAD binding |
Cellular Component |
GO:0005929 cilium GO:0031514 motile cilium |
KEGG |
hsa00040 Pentose and glucuronate interconversions hsa00051 Fructose and mannose metabolism hsa01100 Metabolic pathways |
Reactome |
R-HSA-5661270: Catabolism of glucuronate to xylulose-5-phosphate R-HSA-5652227: Fructose biosynthesis R-HSA-5652084: Fructose metabolism R-HSA-1430728: Metabolism R-HSA-71387: Metabolism of carbohydrates |
Summary | |
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Symbol | SORD |
Name | sorbitol dehydrogenase |
Aliases | HEL-S-95n1; L-iditol 2-dehydrogenase; epididymis secretory sperm binding protein Li 95n |
Chromosomal Location | 15q15-q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between SORD and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | SORD |
Name | sorbitol dehydrogenase |
Aliases | HEL-S-95n1; L-iditol 2-dehydrogenase; epididymis secretory sperm binding protein Li 95n |
Chromosomal Location | 15q15-q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of SORD in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | SORD |
Name | sorbitol dehydrogenase |
Aliases | HEL-S-95n1; L-iditol 2-dehydrogenase; epididymis secretory sperm binding protein Li 95n |
Chromosomal Location | 15q15-q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of SORD in various data sets.
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Points in the above scatter plot represent the mutation difference of SORD in various data sets.
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Summary | |
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Symbol | SORD |
Name | sorbitol dehydrogenase |
Aliases | HEL-S-95n1; L-iditol 2-dehydrogenase; epididymis secretory sperm binding protein Li 95n |
Chromosomal Location | 15q15-q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SORD. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | SORD |
Name | sorbitol dehydrogenase |
Aliases | HEL-S-95n1; L-iditol 2-dehydrogenase; epididymis secretory sperm binding protein Li 95n |
Chromosomal Location | 15q15-q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SORD. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SORD. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | SORD |
Name | sorbitol dehydrogenase |
Aliases | HEL-S-95n1; L-iditol 2-dehydrogenase; epididymis secretory sperm binding protein Li 95n |
Chromosomal Location | 15q15-q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SORD. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | SORD |
Name | sorbitol dehydrogenase |
Aliases | HEL-S-95n1; L-iditol 2-dehydrogenase; epididymis secretory sperm binding protein Li 95n |
Chromosomal Location | 15q15-q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of SORD expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | SORD |
Name | sorbitol dehydrogenase |
Aliases | HEL-S-95n1; L-iditol 2-dehydrogenase; epididymis secretory sperm binding protein Li 95n |
Chromosomal Location | 15q15-q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between SORD and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | SORD |
Name | sorbitol dehydrogenase |
Aliases | HEL-S-95n1; L-iditol 2-dehydrogenase; epididymis secretory sperm binding protein Li 95n |
Chromosomal Location | 15q15-q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting SORD collected from DrugBank database. |
Details on drugs targeting SORD.
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