Summary | |
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Symbol | SOX11 |
Name | SRY (sex determining region Y)-box 11 |
Aliases | SRY-related HMG-box gene 11; MRD27; SRY (sex-determining region Y)-box 11; Transcription factor SOX-11 |
Chromosomal Location | 2p25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus |
Domain |
PF00505 HMG (high mobility group) box |
Function |
Transcriptional factor involved in the embryonic neurogenesis. May also have a role in tissue modeling during development. |
Biological Process |
GO:0000075 cell cycle checkpoint GO:0001501 skeletal system development GO:0001503 ossification GO:0001649 osteoblast differentiation GO:0001654 eye development GO:0001655 urogenital system development GO:0001822 kidney development GO:0001838 embryonic epithelial tube formation GO:0001841 neural tube formation GO:0002011 morphogenesis of an epithelial sheet GO:0002065 columnar/cuboidal epithelial cell differentiation GO:0002072 optic cup morphogenesis involved in camera-type eye development GO:0002088 lens development in camera-type eye GO:0002089 lens morphogenesis in camera-type eye GO:0002683 negative regulation of immune system process GO:0002694 regulation of leukocyte activation GO:0002695 negative regulation of leukocyte activation GO:0003007 heart morphogenesis GO:0003151 outflow tract morphogenesis GO:0003205 cardiac chamber development GO:0003206 cardiac chamber morphogenesis GO:0003207 cardiac chamber formation GO:0003208 cardiac ventricle morphogenesis GO:0003211 cardiac ventricle formation GO:0003231 cardiac ventricle development GO:0003279 cardiac septum development GO:0003281 ventricular septum development GO:0003357 noradrenergic neuron differentiation GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007179 transforming growth factor beta receptor signaling pathway GO:0007423 sensory organ development GO:0007507 heart development GO:0007517 muscle organ development GO:0007519 skeletal muscle tissue development GO:0009914 hormone transport GO:0010001 glial cell differentiation GO:0010720 positive regulation of cell development GO:0010721 negative regulation of cell development GO:0010817 regulation of hormone levels GO:0010948 negative regulation of cell cycle process GO:0014003 oligodendrocyte development GO:0014009 glial cell proliferation GO:0014013 regulation of gliogenesis GO:0014014 negative regulation of gliogenesis GO:0014031 mesenchymal cell development GO:0014032 neural crest cell development GO:0014033 neural crest cell differentiation GO:0014706 striated muscle tissue development GO:0016331 morphogenesis of embryonic epithelium GO:0017015 regulation of transforming growth factor beta receptor signaling pathway GO:0021510 spinal cord development GO:0021782 glial cell development GO:0021915 neural tube development GO:0023061 signal release GO:0030278 regulation of ossification GO:0030323 respiratory tube development GO:0030324 lung development GO:0030509 BMP signaling pathway GO:0030510 regulation of BMP signaling pathway GO:0030513 positive regulation of BMP signaling pathway GO:0031076 embryonic camera-type eye development GO:0032943 mononuclear cell proliferation GO:0032944 regulation of mononuclear cell proliferation GO:0032945 negative regulation of mononuclear cell proliferation GO:0035107 appendage morphogenesis GO:0035108 limb morphogenesis GO:0035148 tube formation GO:0035239 tube morphogenesis GO:0035329 hippo signaling GO:0035330 regulation of hippo signaling GO:0035332 positive regulation of hippo signaling GO:0035914 skeletal muscle cell differentiation GO:0042063 gliogenesis GO:0043010 camera-type eye development GO:0043392 negative regulation of DNA binding GO:0044770 cell cycle phase transition GO:0045666 positive regulation of neuron differentiation GO:0045667 regulation of osteoblast differentiation GO:0045669 positive regulation of osteoblast differentiation GO:0045778 positive regulation of ossification GO:0045786 negative regulation of cell cycle GO:0046651 lymphocyte proliferation GO:0046879 hormone secretion GO:0046883 regulation of hormone secretion GO:0046887 positive regulation of hormone secretion GO:0048048 embryonic eye morphogenesis GO:0048483 autonomic nervous system development GO:0048485 sympathetic nervous system development GO:0048546 digestive tract morphogenesis GO:0048557 embryonic digestive tract morphogenesis GO:0048562 embryonic organ morphogenesis GO:0048565 digestive tract development GO:0048566 embryonic digestive tract development GO:0048568 embryonic organ development GO:0048592 eye morphogenesis GO:0048593 camera-type eye morphogenesis GO:0048596 embryonic camera-type eye morphogenesis GO:0048704 embryonic skeletal system morphogenesis GO:0048705 skeletal system morphogenesis GO:0048706 embryonic skeletal system development GO:0048709 oligodendrocyte differentiation GO:0048736 appendage development GO:0048762 mesenchymal cell differentiation GO:0048863 stem cell differentiation GO:0048864 stem cell development GO:0050670 regulation of lymphocyte proliferation GO:0050672 negative regulation of lymphocyte proliferation GO:0050673 epithelial cell proliferation GO:0050678 regulation of epithelial cell proliferation GO:0050679 positive regulation of epithelial cell proliferation GO:0050768 negative regulation of neurogenesis GO:0050769 positive regulation of neurogenesis GO:0050865 regulation of cell activation GO:0050866 negative regulation of cell activation GO:0051047 positive regulation of secretion GO:0051098 regulation of binding GO:0051100 negative regulation of binding GO:0051101 regulation of DNA binding GO:0051249 regulation of lymphocyte activation GO:0051250 negative regulation of lymphocyte activation GO:0051961 negative regulation of nervous system development GO:0051962 positive regulation of nervous system development GO:0055123 digestive system development GO:0060021 palate development GO:0060022 hard palate development GO:0060023 soft palate development GO:0060173 limb development GO:0060174 limb bud formation GO:0060251 regulation of glial cell proliferation GO:0060253 negative regulation of glial cell proliferation GO:0060411 cardiac septum morphogenesis GO:0060412 ventricular septum morphogenesis GO:0060425 lung morphogenesis GO:0060485 mesenchyme development GO:0060537 muscle tissue development GO:0060538 skeletal muscle organ development GO:0060541 respiratory system development GO:0060562 epithelial tube morphogenesis GO:0060563 neuroepithelial cell differentiation GO:0060900 embryonic camera-type eye formation GO:0061029 eyelid development in camera-type eye GO:0061053 somite development GO:0061303 cornea development in camera-type eye GO:0061386 closure of optic fissure GO:0070661 leukocyte proliferation GO:0070663 regulation of leukocyte proliferation GO:0070664 negative regulation of leukocyte proliferation GO:0071559 response to transforming growth factor beta GO:0071560 cellular response to transforming growth factor beta stimulus GO:0071772 response to BMP GO:0071773 cellular response to BMP stimulus GO:0072001 renal system development GO:0072089 stem cell proliferation GO:0072091 regulation of stem cell proliferation GO:0072175 epithelial tube formation GO:0072395 signal transduction involved in cell cycle checkpoint GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway GO:0090100 positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway GO:0090287 regulation of cellular response to growth factor stimulus GO:0090596 sensory organ morphogenesis GO:0097166 lens epithelial cell proliferation GO:1901987 regulation of cell cycle phase transition GO:1901988 negative regulation of cell cycle phase transition GO:1903532 positive regulation of secretion by cell GO:1903844 regulation of cellular response to transforming growth factor beta stimulus GO:2000648 positive regulation of stem cell proliferation GO:2000677 regulation of transcription regulatory region DNA binding GO:2000678 negative regulation of transcription regulatory region DNA binding GO:2001109 regulation of lens epithelial cell proliferation GO:2001111 positive regulation of lens epithelial cell proliferation |
Molecular Function |
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001046 core promoter sequence-specific DNA binding GO:0001047 core promoter binding GO:0001076 transcription factor activity, RNA polymerase II transcription factor binding GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001104 RNA polymerase II transcription cofactor activity GO:0001105 RNA polymerase II transcription coactivator activity GO:0001158 enhancer sequence-specific DNA binding GO:0001190 transcriptional activator activity, RNA polymerase II transcription factor binding GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0003713 transcription coactivator activity GO:0008135 translation factor activity, RNA binding GO:0035326 enhancer binding GO:0098811 transcriptional repressor activity, RNA polymerase II activating transcription factor binding |
Cellular Component | - |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | SOX11 |
Name | SRY (sex determining region Y)-box 11 |
Aliases | SRY-related HMG-box gene 11; MRD27; SRY (sex-determining region Y)-box 11; Transcription factor SOX-11 |
Chromosomal Location | 2p25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between SOX11 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | SOX11 |
Name | SRY (sex determining region Y)-box 11 |
Aliases | SRY-related HMG-box gene 11; MRD27; SRY (sex-determining region Y)-box 11; Transcription factor SOX-11 |
Chromosomal Location | 2p25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of SOX11 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | SOX11 |
Name | SRY (sex determining region Y)-box 11 |
Aliases | SRY-related HMG-box gene 11; MRD27; SRY (sex-determining region Y)-box 11; Transcription factor SOX-11 |
Chromosomal Location | 2p25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of SOX11 in various data sets.
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Points in the above scatter plot represent the mutation difference of SOX11 in various data sets.
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Summary | |
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Symbol | SOX11 |
Name | SRY (sex determining region Y)-box 11 |
Aliases | SRY-related HMG-box gene 11; MRD27; SRY (sex-determining region Y)-box 11; Transcription factor SOX-11 |
Chromosomal Location | 2p25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SOX11. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | SOX11 |
Name | SRY (sex determining region Y)-box 11 |
Aliases | SRY-related HMG-box gene 11; MRD27; SRY (sex-determining region Y)-box 11; Transcription factor SOX-11 |
Chromosomal Location | 2p25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SOX11. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SOX11. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | SOX11 |
Name | SRY (sex determining region Y)-box 11 |
Aliases | SRY-related HMG-box gene 11; MRD27; SRY (sex-determining region Y)-box 11; Transcription factor SOX-11 |
Chromosomal Location | 2p25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SOX11. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | SOX11 |
Name | SRY (sex determining region Y)-box 11 |
Aliases | SRY-related HMG-box gene 11; MRD27; SRY (sex-determining region Y)-box 11; Transcription factor SOX-11 |
Chromosomal Location | 2p25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of SOX11 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | SOX11 |
Name | SRY (sex determining region Y)-box 11 |
Aliases | SRY-related HMG-box gene 11; MRD27; SRY (sex-determining region Y)-box 11; Transcription factor SOX-11 |
Chromosomal Location | 2p25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between SOX11 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | SOX11 |
Name | SRY (sex determining region Y)-box 11 |
Aliases | SRY-related HMG-box gene 11; MRD27; SRY (sex-determining region Y)-box 11; Transcription factor SOX-11 |
Chromosomal Location | 2p25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting SOX11 collected from DrugBank database. |
There is no record. |