Summary | |
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Symbol | SOX3 |
Name | SRY (sex determining region Y)-box 3 |
Aliases | panhypopituitarism; GHDX; MRGH; PHPX; SOXB; Transcription factor SOX-3 |
Chromosomal Location | Xq27.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus. |
Domain |
PF00505 HMG (high mobility group) box PF12336 SOX transcription factor |
Function |
Transcription factor required during the formation of the hypothalamo-pituitary axis. May function as a switch in neuronal development. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. Required also within the pharyngeal epithelia for craniofacial morphogenesis. Controls a genetic switch in male development. Is necessary for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells (By similarity). |
Biological Process |
GO:0007423 sensory organ development GO:0007530 sex determination GO:0010721 negative regulation of cell development GO:0021536 diencephalon development GO:0021761 limbic system development GO:0021854 hypothalamus development GO:0021983 pituitary gland development GO:0030900 forebrain development GO:0035270 endocrine system development GO:0045665 negative regulation of neuron differentiation GO:0048732 gland development GO:0050768 negative regulation of neurogenesis GO:0051961 negative regulation of nervous system development GO:0060324 face development |
Molecular Function |
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding GO:0001046 core promoter sequence-specific DNA binding GO:0001047 core promoter binding GO:0001076 transcription factor activity, RNA polymerase II transcription factor binding GO:0001104 RNA polymerase II transcription cofactor activity GO:0001106 RNA polymerase II transcription corepressor activity GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding GO:0003714 transcription corepressor activity |
Cellular Component | - |
KEGG | - |
Reactome |
R-HSA-3769402: Deactivation of the beta-catenin transactivating complex R-HSA-162582: Signal Transduction R-HSA-195721: Signaling by Wnt R-HSA-201681: TCF dependent signaling in response to WNT |
Summary | |
---|---|
Symbol | SOX3 |
Name | SRY (sex determining region Y)-box 3 |
Aliases | panhypopituitarism; GHDX; MRGH; PHPX; SOXB; Transcription factor SOX-3 |
Chromosomal Location | Xq27.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between SOX3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | SOX3 |
Name | SRY (sex determining region Y)-box 3 |
Aliases | panhypopituitarism; GHDX; MRGH; PHPX; SOXB; Transcription factor SOX-3 |
Chromosomal Location | Xq27.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of SOX3 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | SOX3 |
Name | SRY (sex determining region Y)-box 3 |
Aliases | panhypopituitarism; GHDX; MRGH; PHPX; SOXB; Transcription factor SOX-3 |
Chromosomal Location | Xq27.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of SOX3 in various data sets.
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Points in the above scatter plot represent the mutation difference of SOX3 in various data sets.
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Summary | |
---|---|
Symbol | SOX3 |
Name | SRY (sex determining region Y)-box 3 |
Aliases | panhypopituitarism; GHDX; MRGH; PHPX; SOXB; Transcription factor SOX-3 |
Chromosomal Location | Xq27.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SOX3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | SOX3 |
Name | SRY (sex determining region Y)-box 3 |
Aliases | panhypopituitarism; GHDX; MRGH; PHPX; SOXB; Transcription factor SOX-3 |
Chromosomal Location | Xq27.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SOX3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SOX3. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | SOX3 |
Name | SRY (sex determining region Y)-box 3 |
Aliases | panhypopituitarism; GHDX; MRGH; PHPX; SOXB; Transcription factor SOX-3 |
Chromosomal Location | Xq27.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SOX3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | SOX3 |
Name | SRY (sex determining region Y)-box 3 |
Aliases | panhypopituitarism; GHDX; MRGH; PHPX; SOXB; Transcription factor SOX-3 |
Chromosomal Location | Xq27.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of SOX3 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | SOX3 |
Name | SRY (sex determining region Y)-box 3 |
Aliases | panhypopituitarism; GHDX; MRGH; PHPX; SOXB; Transcription factor SOX-3 |
Chromosomal Location | Xq27.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between SOX3 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | SOX3 |
Name | SRY (sex determining region Y)-box 3 |
Aliases | panhypopituitarism; GHDX; MRGH; PHPX; SOXB; Transcription factor SOX-3 |
Chromosomal Location | Xq27.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting SOX3 collected from DrugBank database. |
There is no record. |