Summary | |
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Symbol | SOX5 |
Name | SRY (sex determining region Y)-box 5 |
Aliases | L-SOX5; MGC35153; L-SOX5B; L-SOX5F; Transcription factor SOX-5 |
Chromosomal Location | 12p12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus |
Domain |
PF00505 HMG (high mobility group) box |
Function |
Binds specifically to the DNA sequence 5'-AACAAT-3'. Activates transcription of COL2A1 and AGC1 in vitro. |
Biological Process |
GO:0001501 skeletal system development GO:0002062 chondrocyte differentiation GO:0007405 neuroblast proliferation GO:0008356 asymmetric cell division GO:0017145 stem cell division GO:0032330 regulation of chondrocyte differentiation GO:0032332 positive regulation of chondrocyte differentiation GO:0036445 neuronal stem cell division GO:0045165 cell fate commitment GO:0048103 somatic stem cell division GO:0048863 stem cell differentiation GO:0051216 cartilage development GO:0055057 neuroblast division GO:0055059 asymmetric neuroblast division GO:0061035 regulation of cartilage development GO:0061036 positive regulation of cartilage development GO:0061351 neural precursor cell proliferation GO:0061448 connective tissue development GO:0071559 response to transforming growth factor beta GO:0071560 cellular response to transforming growth factor beta stimulus GO:0072089 stem cell proliferation GO:0072497 mesenchymal stem cell differentiation GO:0098722 asymmetric stem cell division GO:2000736 regulation of stem cell differentiation GO:2000738 positive regulation of stem cell differentiation GO:2000739 regulation of mesenchymal stem cell differentiation GO:2000741 positive regulation of mesenchymal stem cell differentiation |
Molecular Function | - |
Cellular Component | - |
KEGG | - |
Reactome | - |
Summary | |
---|---|
Symbol | SOX5 |
Name | SRY (sex determining region Y)-box 5 |
Aliases | L-SOX5; MGC35153; L-SOX5B; L-SOX5F; Transcription factor SOX-5 |
Chromosomal Location | 12p12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between SOX5 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between SOX5 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | SOX5 |
Name | SRY (sex determining region Y)-box 5 |
Aliases | L-SOX5; MGC35153; L-SOX5B; L-SOX5F; Transcription factor SOX-5 |
Chromosomal Location | 12p12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of SOX5 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | SOX5 |
Name | SRY (sex determining region Y)-box 5 |
Aliases | L-SOX5; MGC35153; L-SOX5B; L-SOX5F; Transcription factor SOX-5 |
Chromosomal Location | 12p12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of SOX5 in various data sets.
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Points in the above scatter plot represent the mutation difference of SOX5 in various data sets.
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Summary | |
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Symbol | SOX5 |
Name | SRY (sex determining region Y)-box 5 |
Aliases | L-SOX5; MGC35153; L-SOX5B; L-SOX5F; Transcription factor SOX-5 |
Chromosomal Location | 12p12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SOX5. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | SOX5 |
Name | SRY (sex determining region Y)-box 5 |
Aliases | L-SOX5; MGC35153; L-SOX5B; L-SOX5F; Transcription factor SOX-5 |
Chromosomal Location | 12p12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SOX5. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SOX5. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | SOX5 |
Name | SRY (sex determining region Y)-box 5 |
Aliases | L-SOX5; MGC35153; L-SOX5B; L-SOX5F; Transcription factor SOX-5 |
Chromosomal Location | 12p12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SOX5. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | SOX5 |
Name | SRY (sex determining region Y)-box 5 |
Aliases | L-SOX5; MGC35153; L-SOX5B; L-SOX5F; Transcription factor SOX-5 |
Chromosomal Location | 12p12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of SOX5 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | SOX5 |
Name | SRY (sex determining region Y)-box 5 |
Aliases | L-SOX5; MGC35153; L-SOX5B; L-SOX5F; Transcription factor SOX-5 |
Chromosomal Location | 12p12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between SOX5 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |