Browse SOX6

Summary
SymbolSOX6
NameSRY (sex determining region Y)-box 6
Aliases HSSOX6; SOXD; SRY-box containing gene 6; Transcription factor SOX-6
Chromosomal Location11p15.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus
Domain PF00505 HMG (high mobility group) box
Function

Transcriptional activator. Binds specifically to the DNA sequence 5'-AACAAT-3'. Plays a key role in several developmental processes, including neurogenesis and skeleton formation.

> Gene Ontology
 
Biological Process GO:0001501 skeletal system development
GO:0001701 in utero embryonic development
GO:0001708 cell fate specification
GO:0002062 chondrocyte differentiation
GO:0002262 myeloid cell homeostasis
GO:0007507 heart development
GO:0007517 muscle organ development
GO:0009791 post-embryonic development
GO:0010001 glial cell differentiation
GO:0014706 striated muscle tissue development
GO:0016202 regulation of striated muscle tissue development
GO:0016458 gene silencing
GO:0021778 oligodendrocyte cell fate specification
GO:0021779 oligodendrocyte cell fate commitment
GO:0021780 glial cell fate specification
GO:0021781 glial cell fate commitment
GO:0030099 myeloid cell differentiation
GO:0030218 erythrocyte differentiation
GO:0032330 regulation of chondrocyte differentiation
GO:0032332 positive regulation of chondrocyte differentiation
GO:0034101 erythrocyte homeostasis
GO:0035051 cardiocyte differentiation
GO:0042063 gliogenesis
GO:0042692 muscle cell differentiation
GO:0045165 cell fate commitment
GO:0045843 negative regulation of striated muscle tissue development
GO:0048634 regulation of muscle organ development
GO:0048635 negative regulation of muscle organ development
GO:0048708 astrocyte differentiation
GO:0048709 oligodendrocyte differentiation
GO:0048738 cardiac muscle tissue development
GO:0048821 erythrocyte development
GO:0048863 stem cell differentiation
GO:0048872 homeostasis of number of cells
GO:0051146 striated muscle cell differentiation
GO:0051147 regulation of muscle cell differentiation
GO:0051148 negative regulation of muscle cell differentiation
GO:0051153 regulation of striated muscle cell differentiation
GO:0051154 negative regulation of striated muscle cell differentiation
GO:0051216 cartilage development
GO:0055007 cardiac muscle cell differentiation
GO:0055024 regulation of cardiac muscle tissue development
GO:0055026 negative regulation of cardiac muscle tissue development
GO:0060537 muscle tissue development
GO:0061035 regulation of cartilage development
GO:0061036 positive regulation of cartilage development
GO:0061448 connective tissue development
GO:0061515 myeloid cell development
GO:0071559 response to transforming growth factor beta
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:0072497 mesenchymal stem cell differentiation
GO:1901861 regulation of muscle tissue development
GO:1901862 negative regulation of muscle tissue development
GO:1905207 regulation of cardiocyte differentiation
GO:1905208 negative regulation of cardiocyte differentiation
GO:2000725 regulation of cardiac muscle cell differentiation
GO:2000726 negative regulation of cardiac muscle cell differentiation
GO:2000736 regulation of stem cell differentiation
GO:2000738 positive regulation of stem cell differentiation
GO:2000739 regulation of mesenchymal stem cell differentiation
GO:2000741 positive regulation of mesenchymal stem cell differentiation
Molecular Function GO:0046982 protein heterodimerization activity
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-3769402: Deactivation of the beta-catenin transactivating complex
R-HSA-162582: Signal Transduction
R-HSA-195721: Signaling by Wnt
R-HSA-201681: TCF dependent signaling in response to WNT
Summary
SymbolSOX6
NameSRY (sex determining region Y)-box 6
Aliases HSSOX6; SOXD; SRY-box containing gene 6; Transcription factor SOX-6
Chromosomal Location11p15.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between SOX6 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between SOX6 and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
18224680GliomaPromote immunity (T cell function); essential for immunotherapyInduction of protective and therapeutic antitumor immunity by a DNA vaccine with a glioma antigen, SOX6. Following SOX6-DNA vaccination, CTLs specific for SOX6-expressing glioma cells were induced, while normal autologous-cells that had restrictedly expressed SOX6 during embryogenesis were not destroyed.
Summary
SymbolSOX6
NameSRY (sex determining region Y)-box 6
Aliases HSSOX6; SOXD; SRY-box containing gene 6; Transcription factor SOX-6
Chromosomal Location11p15.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of SOX6 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolSOX6
NameSRY (sex determining region Y)-box 6
Aliases HSSOX6; SOXD; SRY-box containing gene 6; Transcription factor SOX-6
Chromosomal Location11p15.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of SOX6 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.7020.291
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)651.0840.366
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.4020.735
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.3080.568
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.3360.845
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.2520.88
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.0450.96
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.5620.732
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.7570.676
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-1.0340.234
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-1.310.259
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.220.29
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of SOX6 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14177.107.10.452
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103100101
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.72.711
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.73.40.31
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38275.305.30.507
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16146.206.21
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 111307.7-7.71
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 51208.3-8.31
Summary
SymbolSOX6
NameSRY (sex determining region Y)-box 6
Aliases HSSOX6; SOXD; SRY-box containing gene 6; Transcription factor SOX-6
Chromosomal Location11p15.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SOX6. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolSOX6
NameSRY (sex determining region Y)-box 6
Aliases HSSOX6; SOXD; SRY-box containing gene 6; Transcription factor SOX-6
Chromosomal Location11p15.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SOX6. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SOX6.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolSOX6
NameSRY (sex determining region Y)-box 6
Aliases HSSOX6; SOXD; SRY-box containing gene 6; Transcription factor SOX-6
Chromosomal Location11p15.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SOX6. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolSOX6
NameSRY (sex determining region Y)-box 6
Aliases HSSOX6; SOXD; SRY-box containing gene 6; Transcription factor SOX-6
Chromosomal Location11p15.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of SOX6 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolSOX6
NameSRY (sex determining region Y)-box 6
Aliases HSSOX6; SOXD; SRY-box containing gene 6; Transcription factor SOX-6
Chromosomal Location11p15.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between SOX6 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolSOX6
NameSRY (sex determining region Y)-box 6
Aliases HSSOX6; SOXD; SRY-box containing gene 6; Transcription factor SOX-6
Chromosomal Location11p15.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting SOX6 collected from DrugBank database.
> Drugs from DrugBank database
 

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