Summary | |
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Symbol | SOX7 |
Name | SRY (sex determining region Y)-box 7 |
Aliases | Transcription factor SOX-7 |
Chromosomal Location | 8p22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus Cytoplasm |
Domain |
PF00505 HMG (high mobility group) box PF12067 Sox 17/18 central domain |
Function |
Binds to and activates the CDH5 promoter, hence plays a role in the transcriptional regulation of genes expressed in the hemogenic endothelium and blocks further differentiation into blood precursors (By similarity). May be required for the survival of both hematopoietic and endothelial precursors during specification (By similarity). Competes with GATA4 for binding and activation of the FGF3 promoter (By similarity). Represses Wnt/beta-catenin-stimulated transcription, probably by targeting CTNNB1 to proteasomal degradation. Binds the DNA sequence 5'-AACAAT-3'. |
Biological Process |
GO:0001704 formation of primary germ layer GO:0001706 endoderm formation GO:0007369 gastrulation GO:0007492 endoderm development GO:0010950 positive regulation of endopeptidase activity GO:0010952 positive regulation of peptidase activity GO:0016055 Wnt signaling pathway GO:0030111 regulation of Wnt signaling pathway GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0045862 positive regulation of proteolysis GO:0052547 regulation of peptidase activity GO:0052548 regulation of endopeptidase activity GO:0060070 canonical Wnt signaling pathway GO:0060828 regulation of canonical Wnt signaling pathway GO:0198738 cell-cell signaling by wnt GO:2000116 regulation of cysteine-type endopeptidase activity GO:2001056 positive regulation of cysteine-type endopeptidase activity |
Molecular Function |
GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding |
Cellular Component | - |
KEGG | - |
Reactome |
R-HSA-3769402: Deactivation of the beta-catenin transactivating complex R-HSA-162582: Signal Transduction R-HSA-195721: Signaling by Wnt R-HSA-201681: TCF dependent signaling in response to WNT |
Summary | |
---|---|
Symbol | SOX7 |
Name | SRY (sex determining region Y)-box 7 |
Aliases | Transcription factor SOX-7 |
Chromosomal Location | 8p22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between SOX7 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | SOX7 |
Name | SRY (sex determining region Y)-box 7 |
Aliases | Transcription factor SOX-7 |
Chromosomal Location | 8p22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of SOX7 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | SOX7 |
Name | SRY (sex determining region Y)-box 7 |
Aliases | Transcription factor SOX-7 |
Chromosomal Location | 8p22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of SOX7 in various data sets.
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Points in the above scatter plot represent the mutation difference of SOX7 in various data sets.
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Summary | |
---|---|
Symbol | SOX7 |
Name | SRY (sex determining region Y)-box 7 |
Aliases | Transcription factor SOX-7 |
Chromosomal Location | 8p22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SOX7. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | SOX7 |
Name | SRY (sex determining region Y)-box 7 |
Aliases | Transcription factor SOX-7 |
Chromosomal Location | 8p22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SOX7. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SOX7. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | SOX7 |
Name | SRY (sex determining region Y)-box 7 |
Aliases | Transcription factor SOX-7 |
Chromosomal Location | 8p22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SOX7. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | SOX7 |
Name | SRY (sex determining region Y)-box 7 |
Aliases | Transcription factor SOX-7 |
Chromosomal Location | 8p22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of SOX7 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | SOX7 |
Name | SRY (sex determining region Y)-box 7 |
Aliases | Transcription factor SOX-7 |
Chromosomal Location | 8p22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between SOX7 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |