Summary | |
---|---|
Symbol | SOX9 |
Name | SRY (sex determining region Y)-box 9 |
Aliases | CMD1; campomelic dysplasia, autosomal sex-reversal; SRXX2; SRXY10; SRY (sex-determining region Y)-box 9 prot ...... |
Chromosomal Location | 17q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus |
Domain |
PF00505 HMG (high mobility group) box PF12444 Sox developmental protein N terminal |
Function |
Transcriptional regulator (PubMed:24038782). Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219 (By similarity). Plays a role in chondrocyte differentiation (By similarity). Important for normal skeletal development (PubMed:24038782). |
Biological Process |
GO:0001101 response to acid chemical GO:0001501 skeletal system development GO:0001502 cartilage condensation GO:0001503 ossification GO:0001654 eye development GO:0001655 urogenital system development GO:0001656 metanephros development GO:0001657 ureteric bud development GO:0001658 branching involved in ureteric bud morphogenesis GO:0001667 ameboidal-type cell migration GO:0001708 cell fate specification GO:0001754 eye photoreceptor cell differentiation GO:0001763 morphogenesis of a branching structure GO:0001822 kidney development GO:0001823 mesonephros development GO:0001837 epithelial to mesenchymal transition GO:0001838 embryonic epithelial tube formation GO:0001889 liver development GO:0001894 tissue homeostasis GO:0001942 hair follicle development GO:0002053 positive regulation of mesenchymal cell proliferation GO:0002062 chondrocyte differentiation GO:0002063 chondrocyte development GO:0002064 epithelial cell development GO:0002683 negative regulation of immune system process GO:0003007 heart morphogenesis GO:0003170 heart valve development GO:0003179 heart valve morphogenesis GO:0003188 heart valve formation GO:0003197 endocardial cushion development GO:0003203 endocardial cushion morphogenesis GO:0003338 metanephros morphogenesis GO:0003401 axis elongation GO:0003407 neural retina development GO:0003413 chondrocyte differentiation involved in endochondral bone morphogenesis GO:0003415 chondrocyte hypertrophy GO:0006323 DNA packaging GO:0006333 chromatin assembly or disassembly GO:0006334 nucleosome assembly GO:0006338 chromatin remodeling GO:0007173 epidermal growth factor receptor signaling pathway GO:0007219 Notch signaling pathway GO:0007283 spermatogenesis GO:0007423 sensory organ development GO:0007507 heart development GO:0007530 sex determination GO:0007538 primary sex determination GO:0007542 primary sex determination, germ-line GO:0007548 sex differentiation GO:0007586 digestion GO:0008406 gonad development GO:0008544 epidermis development GO:0008584 male gonad development GO:0009612 response to mechanical stimulus GO:0009894 regulation of catabolic process GO:0009896 positive regulation of catabolic process GO:0010001 glial cell differentiation GO:0010463 mesenchymal cell proliferation GO:0010464 regulation of mesenchymal cell proliferation GO:0010631 epithelial cell migration GO:0010632 regulation of epithelial cell migration GO:0010634 positive regulation of epithelial cell migration GO:0010669 epithelial structure maintenance GO:0010721 negative regulation of cell development GO:0014031 mesenchymal cell development GO:0014032 neural crest cell development GO:0014033 neural crest cell differentiation GO:0014065 phosphatidylinositol 3-kinase signaling GO:0014066 regulation of phosphatidylinositol 3-kinase signaling GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling GO:0016049 cell growth GO:0016055 Wnt signaling pathway GO:0016331 morphogenesis of embryonic epithelium GO:0018992 germ-line sex determination GO:0019100 male germ-line sex determination GO:0019827 stem cell population maintenance GO:0019932 second-messenger-mediated signaling GO:0019933 cAMP-mediated signaling GO:0019935 cyclic-nucleotide-mediated signaling GO:0021781 glial cell fate commitment GO:0022404 molting cycle process GO:0022405 hair cycle process GO:0022600 digestive system process GO:0022612 gland morphogenesis GO:0030111 regulation of Wnt signaling pathway GO:0030178 negative regulation of Wnt signaling pathway GO:0030198 extracellular matrix organization GO:0030238 male sex determination GO:0030277 maintenance of gastrointestinal epithelium GO:0030278 regulation of ossification GO:0030279 negative regulation of ossification GO:0030282 bone mineralization GO:0030323 respiratory tube development GO:0030324 lung development GO:0030335 positive regulation of cell migration GO:0030500 regulation of bone mineralization GO:0030502 negative regulation of bone mineralization GO:0030850 prostate gland development GO:0030856 regulation of epithelial cell differentiation GO:0030857 negative regulation of epithelial cell differentiation GO:0030858 positive regulation of epithelial cell differentiation GO:0030879 mammary gland development GO:0030903 notochord development GO:0030916 otic vesicle formation GO:0031016 pancreas development GO:0031018 endocrine pancreas development GO:0031128 developmental induction GO:0031214 biomineral tissue development GO:0031497 chromatin assembly GO:0032330 regulation of chondrocyte differentiation GO:0032331 negative regulation of chondrocyte differentiation GO:0032332 positive regulation of chondrocyte differentiation GO:0032526 response to retinoic acid GO:0032808 lacrimal gland development GO:0034504 protein localization to nucleus GO:0034728 nucleosome organization GO:0035019 somatic stem cell population maintenance GO:0035107 appendage morphogenesis GO:0035108 limb morphogenesis GO:0035148 tube formation GO:0035239 tube morphogenesis GO:0035265 organ growth GO:0035270 endocrine system development GO:0035272 exocrine system development GO:0035622 intrahepatic bile duct development GO:0038127 ERBB signaling pathway GO:0040017 positive regulation of locomotion GO:0042063 gliogenesis GO:0042176 regulation of protein catabolic process GO:0042303 molting cycle GO:0042471 ear morphogenesis GO:0042472 inner ear morphogenesis GO:0042633 hair cycle GO:0042692 muscle cell differentiation GO:0043010 camera-type eye development GO:0043062 extracellular structure organization GO:0043491 protein kinase B signaling GO:0043583 ear development GO:0043588 skin development GO:0044089 positive regulation of cellular component biogenesis GO:0045137 development of primary sexual characteristics GO:0045165 cell fate commitment GO:0045445 myoblast differentiation GO:0045661 regulation of myoblast differentiation GO:0045662 negative regulation of myoblast differentiation GO:0045665 negative regulation of neuron differentiation GO:0045732 positive regulation of protein catabolic process GO:0046530 photoreceptor cell differentiation GO:0046532 regulation of photoreceptor cell differentiation GO:0046533 negative regulation of photoreceptor cell differentiation GO:0046546 development of primary male sexual characteristics GO:0046661 male sex differentiation GO:0048015 phosphatidylinositol-mediated signaling GO:0048017 inositol lipid-mediated signaling GO:0048232 male gamete generation GO:0048562 embryonic organ morphogenesis GO:0048568 embryonic organ development GO:0048588 developmental cell growth GO:0048592 eye morphogenesis GO:0048593 camera-type eye morphogenesis GO:0048608 reproductive structure development GO:0048705 skeletal system morphogenesis GO:0048708 astrocyte differentiation GO:0048709 oligodendrocyte differentiation GO:0048732 gland development GO:0048736 appendage development GO:0048745 smooth muscle tissue development GO:0048754 branching morphogenesis of an epithelial tube GO:0048762 mesenchymal cell differentiation GO:0048839 inner ear development GO:0048863 stem cell differentiation GO:0048864 stem cell development GO:0048871 multicellular organismal homeostasis GO:0048872 homeostasis of number of cells GO:0048873 homeostasis of number of cells within a tissue GO:0050673 epithelial cell proliferation GO:0050678 regulation of epithelial cell proliferation GO:0050679 positive regulation of epithelial cell proliferation GO:0050680 negative regulation of epithelial cell proliferation GO:0050768 negative regulation of neurogenesis GO:0051145 smooth muscle cell differentiation GO:0051147 regulation of muscle cell differentiation GO:0051148 negative regulation of muscle cell differentiation GO:0051216 cartilage development GO:0051272 positive regulation of cellular component movement GO:0051961 negative regulation of nervous system development GO:0060008 Sertoli cell differentiation GO:0060009 Sertoli cell development GO:0060018 astrocyte fate commitment GO:0060041 retina development in camera-type eye GO:0060042 retina morphogenesis in camera-type eye GO:0060070 canonical Wnt signaling pathway GO:0060173 limb development GO:0060174 limb bud formation GO:0060219 camera-type eye photoreceptor cell differentiation GO:0060221 retinal rod cell differentiation GO:0060249 anatomical structure homeostasis GO:0060348 bone development GO:0060349 bone morphogenesis GO:0060350 endochondral bone morphogenesis GO:0060351 cartilage development involved in endochondral bone morphogenesis GO:0060425 lung morphogenesis GO:0060428 lung epithelium development GO:0060433 bronchus development GO:0060438 trachea development GO:0060441 epithelial tube branching involved in lung morphogenesis GO:0060479 lung cell differentiation GO:0060485 mesenchyme development GO:0060487 lung epithelial cell differentiation GO:0060502 epithelial cell proliferation involved in lung morphogenesis GO:0060512 prostate gland morphogenesis GO:0060516 primary prostatic bud elongation GO:0060517 epithelial cell proliferation involved in prostatic bud elongation GO:0060532 bronchus cartilage development GO:0060534 trachea cartilage development GO:0060537 muscle tissue development GO:0060541 respiratory system development GO:0060560 developmental growth involved in morphogenesis GO:0060562 epithelial tube morphogenesis GO:0060602 branch elongation of an epithelium GO:0060675 ureteric bud morphogenesis GO:0060688 regulation of morphogenesis of a branching structure GO:0060729 intestinal epithelial structure maintenance GO:0060736 prostate gland growth GO:0060737 prostate gland morphogenetic growth GO:0060740 prostate gland epithelium morphogenesis GO:0060767 epithelial cell proliferation involved in prostate gland development GO:0060784 regulation of cell proliferation involved in tissue homeostasis GO:0060828 regulation of canonical Wnt signaling pathway GO:0060993 kidney morphogenesis GO:0061008 hepaticobiliary system development GO:0061009 common bile duct development GO:0061035 regulation of cartilage development GO:0061036 positive regulation of cartilage development GO:0061037 negative regulation of cartilage development GO:0061046 regulation of branching involved in lung morphogenesis GO:0061138 morphogenesis of a branching epithelium GO:0061145 lung smooth muscle development GO:0061213 positive regulation of mesonephros development GO:0061217 regulation of mesonephros development GO:0061323 cell proliferation involved in heart morphogenesis GO:0061326 renal tubule development GO:0061333 renal tubule morphogenesis GO:0061448 connective tissue development GO:0061458 reproductive system development GO:0061614 pri-miRNA transcription from RNA polymerase II promoter GO:0065004 protein-DNA complex assembly GO:0070167 regulation of biomineral tissue development GO:0070168 negative regulation of biomineral tissue development GO:0070371 ERK1 and ERK2 cascade GO:0070384 Harderian gland development GO:0070555 response to interleukin-1 GO:0070849 response to epidermal growth factor GO:0071103 DNA conformation change GO:0071214 cellular response to abiotic stimulus GO:0071229 cellular response to acid chemical GO:0071260 cellular response to mechanical stimulus GO:0071300 cellular response to retinoic acid GO:0071347 cellular response to interleukin-1 GO:0071364 cellular response to epidermal growth factor stimulus GO:0071396 cellular response to lipid GO:0071417 cellular response to organonitrogen compound GO:0071496 cellular response to external stimulus GO:0071503 response to heparin GO:0071504 cellular response to heparin GO:0071559 response to transforming growth factor beta GO:0071560 cellular response to transforming growth factor beta stimulus GO:0071599 otic vesicle development GO:0071600 otic vesicle morphogenesis GO:0071824 protein-DNA complex subunit organization GO:0072001 renal system development GO:0072006 nephron development GO:0072009 nephron epithelium development GO:0072028 nephron morphogenesis GO:0072033 renal vesicle formation GO:0072034 renal vesicle induction GO:0072073 kidney epithelium development GO:0072077 renal vesicle morphogenesis GO:0072078 nephron tubule morphogenesis GO:0072079 nephron tubule formation GO:0072080 nephron tubule development GO:0072087 renal vesicle development GO:0072088 nephron epithelium morphogenesis GO:0072132 mesenchyme morphogenesis GO:0072163 mesonephric epithelium development GO:0072164 mesonephric tubule development GO:0072170 metanephric tubule development GO:0072171 mesonephric tubule morphogenesis GO:0072173 metanephric tubule morphogenesis GO:0072174 metanephric tubule formation GO:0072175 epithelial tube formation GO:0072189 ureter development GO:0072190 ureter urothelium development GO:0072191 ureter smooth muscle development GO:0072193 ureter smooth muscle cell differentiation GO:0072197 ureter morphogenesis GO:0072207 metanephric epithelium development GO:0072210 metanephric nephron development GO:0072234 metanephric nephron tubule development GO:0072243 metanephric nephron epithelium development GO:0072273 metanephric nephron morphogenesis GO:0072282 metanephric nephron tubule morphogenesis GO:0072289 metanephric nephron tubule formation GO:0072497 mesenchymal stem cell differentiation GO:0085029 extracellular matrix assembly GO:0090090 negative regulation of canonical Wnt signaling pathway GO:0090102 cochlea development GO:0090103 cochlea morphogenesis GO:0090130 tissue migration GO:0090132 epithelium migration GO:0090183 regulation of kidney development GO:0090184 positive regulation of kidney development GO:0090189 regulation of branching involved in ureteric bud morphogenesis GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis GO:0090596 sensory organ morphogenesis GO:0097152 mesenchymal cell apoptotic process GO:0098727 maintenance of cell number GO:0098743 cell aggregation GO:0098773 skin epidermis development GO:0198738 cell-cell signaling by wnt GO:1901201 regulation of extracellular matrix assembly GO:1901203 positive regulation of extracellular matrix assembly GO:1902893 regulation of pri-miRNA transcription from RNA polymerase II promoter GO:1902894 negative regulation of pri-miRNA transcription from RNA polymerase II promoter GO:1903053 regulation of extracellular matrix organization GO:1903055 positive regulation of extracellular matrix organization GO:1905330 regulation of morphogenesis of an epithelium GO:1905332 positive regulation of morphogenesis of an epithelium GO:2000018 regulation of male gonad development GO:2000020 positive regulation of male gonad development GO:2000027 regulation of organ morphogenesis GO:2000136 regulation of cell proliferation involved in heart morphogenesis GO:2000138 positive regulation of cell proliferation involved in heart morphogenesis GO:2000147 positive regulation of cell motility GO:2000241 regulation of reproductive process GO:2000243 positive regulation of reproductive process GO:2000736 regulation of stem cell differentiation GO:2000738 positive regulation of stem cell differentiation GO:2000739 regulation of mesenchymal stem cell differentiation GO:2000741 positive regulation of mesenchymal stem cell differentiation GO:2000794 regulation of epithelial cell proliferation involved in lung morphogenesis GO:2000826 regulation of heart morphogenesis GO:2001053 regulation of mesenchymal cell apoptotic process GO:2001054 negative regulation of mesenchymal cell apoptotic process |
Molecular Function |
GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001046 core promoter sequence-specific DNA binding GO:0001047 core promoter binding GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001158 enhancer sequence-specific DNA binding GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0003682 chromatin binding GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding GO:0008013 beta-catenin binding GO:0008134 transcription factor binding GO:0034236 protein kinase A catalytic subunit binding GO:0035326 enhancer binding GO:0036002 pre-mRNA binding GO:0043425 bHLH transcription factor binding GO:0046982 protein heterodimerization activity GO:0051018 protein kinase A binding GO:0097157 pre-mRNA intronic binding |
Cellular Component |
GO:0005667 transcription factor complex GO:0044798 nuclear transcription factor complex |
KEGG |
hsa04024 cAMP signaling pathway |
Reactome |
R-HSA-3769402: Deactivation of the beta-catenin transactivating complex R-HSA-162582: Signal Transduction R-HSA-195721: Signaling by Wnt R-HSA-201681: TCF dependent signaling in response to WNT |
Summary | |
---|---|
Symbol | SOX9 |
Name | SRY (sex determining region Y)-box 9 |
Aliases | CMD1; campomelic dysplasia, autosomal sex-reversal; SRXX2; SRXY10; SRY (sex-determining region Y)-box 9 prot ...... |
Chromosomal Location | 17q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between SOX9 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between SOX9 and anti-tumor immunity in human cancer.
|
Summary | |
---|---|
Symbol | SOX9 |
Name | SRY (sex determining region Y)-box 9 |
Aliases | CMD1; campomelic dysplasia, autosomal sex-reversal; SRXX2; SRXY10; SRY (sex-determining region Y)-box 9 prot ...... |
Chromosomal Location | 17q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
[ TOP ]
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Statistical results of SOX9 in screening data sets for detecting immune reponses.
|
Summary | |
---|---|
Symbol | SOX9 |
Name | SRY (sex determining region Y)-box 9 |
Aliases | CMD1; campomelic dysplasia, autosomal sex-reversal; SRXX2; SRXY10; SRY (sex-determining region Y)-box 9 prot ...... |
Chromosomal Location | 17q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of SOX9 in various data sets.
|
Points in the above scatter plot represent the mutation difference of SOX9 in various data sets.
|
Summary | |
---|---|
Symbol | SOX9 |
Name | SRY (sex determining region Y)-box 9 |
Aliases | CMD1; campomelic dysplasia, autosomal sex-reversal; SRXX2; SRXY10; SRY (sex-determining region Y)-box 9 prot ...... |
Chromosomal Location | 17q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SOX9. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | SOX9 |
Name | SRY (sex determining region Y)-box 9 |
Aliases | CMD1; campomelic dysplasia, autosomal sex-reversal; SRXX2; SRXY10; SRY (sex-determining region Y)-box 9 prot ...... |
Chromosomal Location | 17q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SOX9. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SOX9. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | SOX9 |
Name | SRY (sex determining region Y)-box 9 |
Aliases | CMD1; campomelic dysplasia, autosomal sex-reversal; SRXX2; SRXY10; SRY (sex-determining region Y)-box 9 prot ...... |
Chromosomal Location | 17q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SOX9. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | SOX9 |
Name | SRY (sex determining region Y)-box 9 |
Aliases | CMD1; campomelic dysplasia, autosomal sex-reversal; SRXX2; SRXY10; SRY (sex-determining region Y)-box 9 prot ...... |
Chromosomal Location | 17q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of SOX9 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | SOX9 |
Name | SRY (sex determining region Y)-box 9 |
Aliases | CMD1; campomelic dysplasia, autosomal sex-reversal; SRXX2; SRXY10; SRY (sex-determining region Y)-box 9 prot ...... |
Chromosomal Location | 17q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between SOX9 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | SOX9 |
Name | SRY (sex determining region Y)-box 9 |
Aliases | CMD1; campomelic dysplasia, autosomal sex-reversal; SRXX2; SRXY10; SRY (sex-determining region Y)-box 9 prot ...... |
Chromosomal Location | 17q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting SOX9 collected from DrugBank database. |
There is no record. |