Summary | |
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Symbol | SPEN |
Name | spen family transcriptional repressor |
Aliases | KIAA0929; MINT; SHARP; RBM15C; SPEN homolog, transcriptional regulator (Drosophila); HIAA0929; Msx2 interact ...... |
Chromosomal Location | 1p36 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus Note=Associates with chromatin. |
Domain |
PF00076 RNA recognition motif. (a.k.a. RRM PF07744 SPOC domain |
Function |
May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. |
Biological Process |
GO:0000375 RNA splicing, via transesterification reactions GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile GO:0000398 mRNA splicing, via spliceosome GO:0006397 mRNA processing GO:0007219 Notch signaling pathway GO:0008380 RNA splicing GO:0010720 positive regulation of cell development GO:0050769 positive regulation of neurogenesis GO:0051962 positive regulation of nervous system development |
Molecular Function |
GO:0001076 transcription factor activity, RNA polymerase II transcription factor binding GO:0001085 RNA polymerase II transcription factor binding GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding GO:0008134 transcription factor binding |
Cellular Component |
GO:0017053 transcriptional repressor complex |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | SPEN |
Name | spen family transcriptional repressor |
Aliases | KIAA0929; MINT; SHARP; RBM15C; SPEN homolog, transcriptional regulator (Drosophila); HIAA0929; Msx2 interact ...... |
Chromosomal Location | 1p36 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between SPEN and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | SPEN |
Name | spen family transcriptional repressor |
Aliases | KIAA0929; MINT; SHARP; RBM15C; SPEN homolog, transcriptional regulator (Drosophila); HIAA0929; Msx2 interact ...... |
Chromosomal Location | 1p36 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of SPEN in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | SPEN |
Name | spen family transcriptional repressor |
Aliases | KIAA0929; MINT; SHARP; RBM15C; SPEN homolog, transcriptional regulator (Drosophila); HIAA0929; Msx2 interact ...... |
Chromosomal Location | 1p36 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of SPEN in various data sets.
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Points in the above scatter plot represent the mutation difference of SPEN in various data sets.
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Summary | |
---|---|
Symbol | SPEN |
Name | spen family transcriptional repressor |
Aliases | KIAA0929; MINT; SHARP; RBM15C; SPEN homolog, transcriptional regulator (Drosophila); HIAA0929; Msx2 interact ...... |
Chromosomal Location | 1p36 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SPEN. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | SPEN |
Name | spen family transcriptional repressor |
Aliases | KIAA0929; MINT; SHARP; RBM15C; SPEN homolog, transcriptional regulator (Drosophila); HIAA0929; Msx2 interact ...... |
Chromosomal Location | 1p36 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SPEN. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SPEN. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | SPEN |
Name | spen family transcriptional repressor |
Aliases | KIAA0929; MINT; SHARP; RBM15C; SPEN homolog, transcriptional regulator (Drosophila); HIAA0929; Msx2 interact ...... |
Chromosomal Location | 1p36 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SPEN. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | SPEN |
Name | spen family transcriptional repressor |
Aliases | KIAA0929; MINT; SHARP; RBM15C; SPEN homolog, transcriptional regulator (Drosophila); HIAA0929; Msx2 interact ...... |
Chromosomal Location | 1p36 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of SPEN expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | SPEN |
Name | spen family transcriptional repressor |
Aliases | KIAA0929; MINT; SHARP; RBM15C; SPEN homolog, transcriptional regulator (Drosophila); HIAA0929; Msx2 interact ...... |
Chromosomal Location | 1p36 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between SPEN and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | SPEN |
Name | spen family transcriptional repressor |
Aliases | KIAA0929; MINT; SHARP; RBM15C; SPEN homolog, transcriptional regulator (Drosophila); HIAA0929; Msx2 interact ...... |
Chromosomal Location | 1p36 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting SPEN collected from DrugBank database. |
There is no record. |