Summary | |
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Symbol | SPON2 |
Name | spondin 2, extracellular matrix protein |
Aliases | DIL1; Mindin; M-spondin; DIL-1; differentially expressed in cancerous and non-cancerous lung cells 1; Spondi ...... |
Chromosomal Location | 4p16.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted, extracellular space, extracellular matrix |
Domain |
PF06468 Spondin_N PF00090 Thrombospondin type 1 domain |
Function |
Cell adhesion protein that promotes adhesion and outgrowth of hippocampal embryonic neurons. Binds directly to bacteria and their components and functions as an opsonin for macrophage phagocytosis of bacteria. Essential in the initiation of the innate immune response and represents a unique pattern-recognition molecule in the ECM for microbial pathogens (By similarity). Binds bacterial lipopolysaccharide (LPS). |
Biological Process |
GO:0001819 positive regulation of cytokine production GO:0002237 response to molecule of bacterial origin GO:0002367 cytokine production involved in immune response GO:0002440 production of molecular mediator of immune response GO:0002443 leukocyte mediated immunity GO:0002444 myeloid leukocyte mediated immunity GO:0002448 mast cell mediated immunity GO:0002697 regulation of immune effector process GO:0002699 positive regulation of immune effector process GO:0002700 regulation of production of molecular mediator of immune response GO:0002702 positive regulation of production of molecular mediator of immune response GO:0002718 regulation of cytokine production involved in immune response GO:0002720 positive regulation of cytokine production involved in immune response GO:0006909 phagocytosis GO:0006959 humoral immune response GO:0007409 axonogenesis GO:0007411 axon guidance GO:0008228 opsonization GO:0009615 response to virus GO:0009620 response to fungus GO:0010934 macrophage cytokine production GO:0010935 regulation of macrophage cytokine production GO:0019730 antimicrobial humoral response GO:0019731 antibacterial humoral response GO:0032496 response to lipopolysaccharide GO:0032635 interleukin-6 production GO:0032640 tumor necrosis factor production GO:0032675 regulation of interleukin-6 production GO:0032680 regulation of tumor necrosis factor production GO:0032755 positive regulation of interleukin-6 production GO:0032760 positive regulation of tumor necrosis factor production GO:0042742 defense response to bacterium GO:0043152 induction of bacterial agglutination GO:0048667 cell morphogenesis involved in neuron differentiation GO:0050832 defense response to fungus GO:0051607 defense response to virus GO:0060907 positive regulation of macrophage cytokine production GO:0061081 positive regulation of myeloid leukocyte cytokine production involved in immune response GO:0061082 myeloid leukocyte cytokine production GO:0061564 axon development GO:0071216 cellular response to biotic stimulus GO:0071219 cellular response to molecule of bacterial origin GO:0071222 cellular response to lipopolysaccharide GO:0071396 cellular response to lipid GO:0071706 tumor necrosis factor superfamily cytokine production GO:0097485 neuron projection guidance GO:0098542 defense response to other organism GO:1903555 regulation of tumor necrosis factor superfamily cytokine production GO:1903557 positive regulation of tumor necrosis factor superfamily cytokine production |
Molecular Function |
GO:0001530 lipopolysaccharide binding GO:0003823 antigen binding |
Cellular Component |
GO:0005578 proteinaceous extracellular matrix |
KEGG | - |
Reactome |
R-HSA-5083635: Defective B3GALTL causes Peters-plus syndrome (PpS) R-HSA-1643685: Disease R-HSA-3906995: Diseases associated with O-glycosylation of proteins R-HSA-3781865: Diseases of glycosylation R-HSA-392499: Metabolism of proteins R-HSA-5173214: O-glycosylation of TSR domain-containing proteins R-HSA-5173105: O-linked glycosylation R-HSA-597592: Post-translational protein modification |
Summary | |
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Symbol | SPON2 |
Name | spondin 2, extracellular matrix protein |
Aliases | DIL1; Mindin; M-spondin; DIL-1; differentially expressed in cancerous and non-cancerous lung cells 1; Spondi ...... |
Chromosomal Location | 4p16.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between SPON2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between SPON2 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | SPON2 |
Name | spondin 2, extracellular matrix protein |
Aliases | DIL1; Mindin; M-spondin; DIL-1; differentially expressed in cancerous and non-cancerous lung cells 1; Spondi ...... |
Chromosomal Location | 4p16.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of SPON2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | SPON2 |
Name | spondin 2, extracellular matrix protein |
Aliases | DIL1; Mindin; M-spondin; DIL-1; differentially expressed in cancerous and non-cancerous lung cells 1; Spondi ...... |
Chromosomal Location | 4p16.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of SPON2 in various data sets.
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Points in the above scatter plot represent the mutation difference of SPON2 in various data sets.
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Summary | |
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Symbol | SPON2 |
Name | spondin 2, extracellular matrix protein |
Aliases | DIL1; Mindin; M-spondin; DIL-1; differentially expressed in cancerous and non-cancerous lung cells 1; Spondi ...... |
Chromosomal Location | 4p16.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SPON2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | SPON2 |
Name | spondin 2, extracellular matrix protein |
Aliases | DIL1; Mindin; M-spondin; DIL-1; differentially expressed in cancerous and non-cancerous lung cells 1; Spondi ...... |
Chromosomal Location | 4p16.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SPON2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SPON2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | SPON2 |
Name | spondin 2, extracellular matrix protein |
Aliases | DIL1; Mindin; M-spondin; DIL-1; differentially expressed in cancerous and non-cancerous lung cells 1; Spondi ...... |
Chromosomal Location | 4p16.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SPON2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | SPON2 |
Name | spondin 2, extracellular matrix protein |
Aliases | DIL1; Mindin; M-spondin; DIL-1; differentially expressed in cancerous and non-cancerous lung cells 1; Spondi ...... |
Chromosomal Location | 4p16.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of SPON2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | SPON2 |
Name | spondin 2, extracellular matrix protein |
Aliases | DIL1; Mindin; M-spondin; DIL-1; differentially expressed in cancerous and non-cancerous lung cells 1; Spondi ...... |
Chromosomal Location | 4p16.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between SPON2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | SPON2 |
Name | spondin 2, extracellular matrix protein |
Aliases | DIL1; Mindin; M-spondin; DIL-1; differentially expressed in cancerous and non-cancerous lung cells 1; Spondi ...... |
Chromosomal Location | 4p16.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting SPON2 collected from DrugBank database. |
There is no record. |